Generic Name: capecitabine (KAP e SYE ta been)
Brand Names: Xeloda
What is Xeloda?
Xeloda (capecitabine) is a cancer medication that interferes with the growth of cancer cells and slows their spread in the body.
Xeloda is used to treat breast cancer and colon or rectum cancer that has spread to other parts of the body.
Xeloda is often used in combination with other cancer medications and/or radiation treatments.
Xeloda may also be used for purposes not listed in this medication guide.
You should not take Xeloda if you are allergic to capecitabine or fluorouracil (Adrucil), or if you have severe kidney disease or a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency.
Xeloda can have long lasting effects on your body. You may need frequent medical tests while you are using this medication and for a short time after your treatment ends.
Xeloda can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).
Before taking this medicine
You should not take Xeloda if you are allergic to capecitabine or fluorouracil (Adrucil), or if you have:
severe kidney disease; or
a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency.
To make sure Xeloda is safe for you, tell your doctor if you have any of these conditions:
a history of coronary artery disease; or
if you take a blood thinner (warfarin, Coumadin, Jantoven).
FDA pregnancy category D. Do not use Xeloda if you are pregnant. It could harm the unborn baby.
See also: Pregnancy and breastfeeding warnings (in more detail)
Use birth control to prevent pregnancy while you are taking Xeloda, whether you are a man or a woman. Tell your doctor if a pregnancy occurs during treatment.
It is not known whether capecitabine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking Xeloda.
How should I take Xeloda?
Take Xeloda exactly as prescribed by your doctor. Follow the directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
During the weeks when you take Xeloda, take the medication once in the morning and once in the evening, unless your doctor tells you otherwise. You may also be given other medications as part of a combination cancer treatment.
Xeloda should be taken with food or within 30 minutes after eating a meal.
Take this medication with a full glass (8 ounces) of water.
You may need frequent medical tests at your doctor's office to be sure this medication is not causing harmful effects. Your cancer treatments may be delayed based on the results of these tests. Xeloda can have long lasting effects on your body. You may also need medical tests for a short time after your treatment ends.
You must remain under the care of a doctor while you are taking Xeloda.
Store Xeloda at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include fever, nausea, vomiting, diarrhea, blood in your stools, coughing up blood.
What should I avoid?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Capecitabine can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Patients and caregivers should wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Body fluids should not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.
Xeloda side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Xeloda: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
nausea, loss of appetite, eating much less than usual, vomiting (more than once in 24 hours);
severe diarrhea (more than 4 times per day, or during the night);
bloody, black, or tarry stools;
coughing up blood or vomit that looks like coffee grounds;
fever, chills, body aches, flu symptoms, easy bruising or bleeding, white patches or sores inside your mouth or on your lips;
pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
pain, tenderness, redness, swelling, blistering, or peeling skin on your hands or feet;
swelling, rapid weight gain; or
jaundice (yellowing of the skin or eyes).
Other common Xeloda side effects may include:
stomach pain or upset, constipation;
mild skin rash; or
numbness or tingling in your hands or feet.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Xeloda?
Tell your doctor about all medications you use, and those you start or stop using during your treatment with Xeloda, especially:
heart or blood pressure medication;
oral diabetes medication; or
NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others.
This list is not complete. Other drugs may interact with Xeloda, including prescription, over-the-counter, vitamin, and herbal products. Not all possible interactions are listed in this medication guide.
More about Xeloda (capecitabine)
Related treatment guides
Where can I get more information?
- Your doctor or pharmacist can provide more information about Xeloda.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Xeloda only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2014 Cerner Multum, Inc. Version: 5.02. Revision Date: 2013-07-01, 12:32:03 PM.