Streptozocin Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Pancreatic Cancer

500 mg/m2 IV by rapid injection or short/prolonged infusion once daily for 5 consecutive days every 6 weeks until maximum benefit or treatment limiting toxicity occurs. A dosage escalation is not recommended with this regimen.

Alternatively, 1000 mg/m2 IV by rapid injection or short/prolonged infusion can be administered at weekly intervals for the first 2 weeks. This can be followed by a dosage escalation not to exceed single doses of 1,500 mg/m2 IV in patients who have not achieved a therapeutic response and have not experienced significant toxicity with previous courses.

Renal Dose Adjustments

Data not available.

Liver Dose Adjustments

Data not available.

Precautions

Confusion, lethargy, and depression have been reported in a few patients who were given continuous streptozocin infusion for 5 days.

Do not exceed single doses of 1,500 mg/m2 IV. Doses higher than this may cause azotemia.

Extravasation may cause severe tissue lesions and necrosis. Spontaneous reports of local inflammation (i.e., edema, erythema, burning, tenderness) were reported following extravasation. However, these events resolved the same day or within a few days in most cases.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available.

Other Comments

With the weekly regimen, the median time to onset of response is about 17 days and the time to maximum response is about 35 days. The median total dose to onset of response is about 2,000 mg/m2 IV and the median total dose to maximum response is about 4,000 mg/m2 IV.

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