Procaine penicillin Side Effects
It is possible that some side effects of procaine penicillin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to procaine penicillin: injectable suspension
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur while taking procaine penicillin:
Black or hairy tongue; exaggerated reflexes; mild diarrhea; nausea or vomiting; pain, swelling, or redness at the injection site; twitching.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); aggression or agitation; anxiety; bizarre behavior; blood in stools or urine; chest pain; chills; confusion; depression; extreme tiredness; fainting; fast heartbeat; fear of death; fever; flushing with lightheadedness or fainting; hallucinations; headache; itching; muscle pain; pounding in the chest; rapid breathing; seizures; severe diarrhea; stomach pain/cramps; vaginal irritation or itching; weakness; worsening of skin lesions.
For Healthcare Professionals
Applies to procaine penicillin: intramuscular suspension
Hypersensitivity side effects associated with penicillin have included skin rashes (ranging from maculopapular eruptions to exfoliative dermatitis), urticaria, and serum sickness-like reactions (including chills, fever, edema, arthralgia, and prostration). Anaphylaxis (severe and often fatal) and Jarisch-Herxheimer reaction (as with other treatments for syphilis) have been reported. Procaine toxicity manifestations and hypersensitivity reactions have been reported.[Ref]
Gastrointestinal side effects associated with penicillin G have included pseudomembranous colitis.[Ref]
The onset of pseudomembranous colitis symptoms may occur during or after treatment.[Ref]
Psychiatric side effects have included a syndrome manifested by a variety of central nervous system symptoms such as severe agitation with confusion, visual and auditory hallucinations, and a fear of impending death (Hoigne's syndrome) following procaine penicillin use. Other symptoms associated with this syndrome have included psychosis, seizures, dizziness, tinnitus, cyanosis, palpitations, tachycardia, and abnormal taste perception.[Ref]
Renal side effects associated with parenteral penicillin G have included nephropathy.[Ref]
Hematologic side effects associated with parenteral penicillin G have included hemolytic anemia, leukopenia, and thrombocytopenia.[Ref]
Nervous system side effects associated with parenteral penicillin G have included neuropathy.[Ref]
1. "Product Information. Penicillin G Procaine (procaine penicillin)." Monarch Pharmaceuticals Inc, Bristol, TN.
2. "Product Information. Bicillin C-R 900/300 (benzathine penicillin-procaine penicillin)." Wyeth Laboratories, Philadelphia, PA.
More about procaine penicillin
- Other brands: Wycillin
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