Pioglitazone Side Effects

It is possible that some side effects of pioglitazone may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to pioglitazone: oral tablet

As well as its needed effects, pioglitazone may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking pioglitazone, check with your doctor immediately:

More common
  • Chest pain
  • decreased urine output
  • dilated neck veins
  • extreme fatigue
  • irregular breathing
  • irregular heartbeat
  • problems with teeth
  • shortness of breath
  • swelling of the face, fingers, feet, or lower legs
  • tightness in the chest
  • trouble with breathing
  • weight gain
  • wheezing
Less common
  • Pain or swelling in the arms or legs without an injury
  • pale skin
  • swelling
  • trouble with breathing when active
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Incidence not known
  • Dark urine
  • loss of appetite
  • nausea or vomiting
  • stomach pain
  • unexplained, rapid weight gain
  • yellow eyes or skin

Some pioglitazone side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Blurred vision or other changes in vision
  • cough
  • dry mouth
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • loss of consciousness
  • muscle pain or soreness
  • problems with your teeth
  • runny or stuffy nose
  • sore throat
  • stomachache
  • sweating
  • unexplained weight loss

For Healthcare Professionals

Applies to pioglitazone: oral tablet

Cardiovascular

Common (1% to 10%): Congestive heart failure (including nonfatal and fatal cases), cardiac failure, chest pain

Hypersensitivity

Frequency not reported: Hypersensitivity and allergic reactions

Metabolic

Very common (10% or more): Hypoglycemia (up to 27.3%), increased weight (up to 26.2%)

General

The most commonly reported side effects were hypoglycemia, increased weight, edema, and upper respiratory tract infection.

Hematologic

Frequency not reported: Small reduction in mean hemoglobin and hematocrit

Ocular

Common (1% to 10%): Visual disturbance, abnormal vision
Frequency not reported: Macular edema

Hepatic

Uncommon (0.1% to 1%): Increased alanine aminotransferase
Frequency not reported: Decreased mean values of bilirubin, AST, alkaline phosphatase, and GGT
Postmarketing reports: Hepatocellular dysfunction

Other

Very common (10% or more): Edema (up to 26.7%)
Common (1% to 10%): Fatigue, accidental injury, peripheral edema, asthenia, malaise

Gastrointestinal

Common (1% to 10%): Tooth disorder, tooth abscess, gastroenteritis, diarrhea, upper abdominal pain

Genitourinary

Uncommon (0.1% to 1%): Bladder cancer, urinary tract infection

Musculoskeletal

Common (1% to 10%): Fractures, myalgia, pain in extremity, back pain, cramped legs, arthralgia

Nervous system

Common (1% to 10%): Headache, Hypoesthesia

Psychiatric

Uncommon (0.1% to 1%): Insomnia

Respiratory

Very common (10% or more): Upper respiratory tract infection (up to 13.2%)
Common (1% to 10%): Sinusitis, pharyngitis, bronchitis, influenza

Oncologic

Uncommon (0.1% to 1%): Bladder cancer

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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