Paromomycin Side Effects

Brand Names: Humatin

Please note - some side effects for Paromomycin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Paromomycin - for the Consumer

Paromomycin

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Paromomycin:

Diarrhea; nausea; stomach cramps.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

Paromomycin Side Effects - for the Professional

Paromomycin

Nausea, abdominal cramps, and diarrhea have been reported in patients on doses over 3 g daily.

Side Effects by Body System

Gastrointestinal

Gastrointestinal side effects of paromomycin have commonly included nausea, vomiting, diarrhea, and abdominal discomfort, especially with doses greater than 3 g per day. Malabsorption of xylose and sucrose has been reported. A case of pancreatitis in an AIDS patient has been attributed to paromomycin.

A patient with AIDS developed pancreatitis after five days of therapy with paromomycin for cryptosporidiosis. Serum amylase declined progressively after paromomycin was discontinued, but became elevated after reinstitution of therapy.

Nervous system

Nervous system side effects have rarely included ototoxicity and sensorineural damage, usually in patients who also had hepatic disease. Rarely, patients may also experience headache or vertigo.

Renal

Nephrotoxicity is a consideration with the use of any aminoglycoside, however, paromomycin is poorly absorbed by the gastrointestinal tract. Accumulation of paromomycin may be problematic in patients with impaired renal function and patients treated with multiple or prolonged courses of therapy.

Hepatic

Hepatic side effects have included transient elevated aspartate transaminase (greater than 3 times ULN) and alanine transaminase (greater than 3 times ULN) in patients receiving intramuscular paromomycin during a clinical study.

Local

Local side effects have included injection site pain and swelling in patients receiving intramuscular paromomycin during a clinical study.

Other

Other side effects have included pyrexia in patients receiving intramuscular paromomycin during a clinical study.

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