Paromomycin Side Effects
Brand Names: Humatin
Please note - some side effects for Paromomycin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).
Side Effects of Paromomycin - for the Consumer
Paromomycin
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Paromomycin:
Seek medical attention right away if any of these SEVERE side effects occur when using Paromomycin:Diarrhea; nausea; stomach cramps.
TopSevere allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).
Paromomycin Side Effects - for the Professional
Paromomycin
Nausea, abdominal cramps, and diarrhea have been reported in patients on doses over 3 g daily.
TopSide Effects by Body System
Gastrointestinal
Gastrointestinal side effects of paromomycin have commonly included nausea, vomiting, diarrhea, and abdominal discomfort, especially with doses greater than 3 g per day. Malabsorption of xylose and sucrose has been reported. A case of pancreatitis in an AIDS patient has been attributed to paromomycin.
A patient with AIDS developed pancreatitis after five days of therapy with paromomycin for cryptosporidiosis. Serum amylase declined progressively after paromomycin was discontinued, but became elevated after reinstitution of therapy.
Nervous system
Nervous system side effects have rarely included ototoxicity and sensorineural damage, usually in patients who also had hepatic disease. Rarely, patients may also experience headache or vertigo.
Renal
Nephrotoxicity is a consideration with the use of any aminoglycoside, however, paromomycin is poorly absorbed by the gastrointestinal tract. Accumulation of paromomycin may be problematic in patients with impaired renal function and patients treated with multiple or prolonged courses of therapy.
Hepatic
Hepatic side effects have included transient elevated aspartate transaminase (greater than 3 times ULN) and alanine transaminase (greater than 3 times ULN) in patients receiving intramuscular paromomycin during a clinical study.
Local
Local side effects have included injection site pain and swelling in patients receiving intramuscular paromomycin during a clinical study.
Other
Other side effects have included pyrexia in patients receiving intramuscular paromomycin during a clinical study.
TopDisclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
