Paromomycin Side Effects
Some side effects of paromomycin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to paromomycin: oral capsule
If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:
an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
decreased hearing or ringing in the ears;
little or no urine production; or
Other less serious side effects may be more likely to occur. Continue to take paromomycin and talk to your doctor if you experience
nausea or vomiting;
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to paromomycin: oral capsule
Gastrointestinal side effects of paromomycin have commonly included nausea, vomiting, diarrhea, and abdominal discomfort, especially with doses greater than 3 g per day. Malabsorption of xylose and sucrose has been reported. A case of pancreatitis in an AIDS patient has been attributed to paromomycin.
A patient with AIDS developed pancreatitis after five days of therapy with paromomycin for cryptosporidiosis. Serum amylase declined progressively after paromomycin was discontinued, but became elevated after reinstitution of therapy.
Nervous system side effects have rarely included ototoxicity and sensorineural damage, usually in patients who also had hepatic disease. Rarely, patients may also experience headache or vertigo.
Nephrotoxicity is a consideration with the use of any aminoglycoside, however, paromomycin is poorly absorbed by the gastrointestinal tract. Accumulation of paromomycin may be problematic in patients with impaired renal function and patients treated with multiple or prolonged courses of therapy.
Hepatic side effects have included transient elevated aspartate transaminase (greater than 3 times ULN) and alanine transaminase (greater than 3 times ULN) in patients receiving intramuscular paromomycin during a clinical study.
Local side effects have included injection site pain and swelling in patients receiving intramuscular paromomycin during a clinical study.
Other side effects have included pyrexia in patients receiving intramuscular paromomycin during a clinical study.
More paromomycin resources
- paromomycin Concise Consumer Information (Cerner Multum)
- paromomycin MedFacts Consumer Leaflet (Wolters Kluwer)
- paromomycin Advanced Consumer (Micromedex) - Includes Dosage Information
- Paromomycin Prescribing Information (FDA)
- Humatin Prescribing Information (FDA)
- Paromomycin Sulfate Monograph (AHFS DI)
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