paromomycin

Generic Name: paromomycin (PAR oh moe MYE sin)
Brand Name: Paromycin, Humatin

What is paromomycin?

Paromomycin is an antibiotic that fights bacteria.

Paromomycin is used to treat certain intestinal infections. Paromomycin is also used to treat certain liver problems.

Paromomycin may also be used for purposes not listed here.

What is the most important information I should know about paromomycin?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Slideshow: View Frightful (But Dead Serious) Drug Side Effects

What should I discuss with my healthcare provider before taking paromomycin?

You should not use paromomycin if you are allergic to it.

To make sure paromomycin is safe for you, tell your doctor if you have:

  • kidney disease; or

  • an intestinal disorder such as ulcerative colitis.

It is not known whether paromomycin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether paromomycin passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take paromomycin?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take with food.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Paromomycin will not treat a viral infection such as the common cold or flu.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking paromomycin?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Paromomycin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • diarrhea that is watery or bloody; or

  • little or no urinating.

Common side effects may include:

  • stomach cramps; or

  • mild diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Paromomycin dosing information

Usual Adult Dose for Amebiasis:

25 to 35 mg/kg/day orally in 3 divided doses with meals for 5 to 10 days. Should be used following a course of metronidazole for the treatment of mild to severe, symptomatic disease. Paromomycin is not effective in extraintestinal amebiasis.

Usual Adult Dose for Cryptosporidiosis:

25 to 35 mg/kg/day orally in 2 to 4 divided doses with meals for 10 to 14 days (investigational). Has occasionally been used for up to 4 to 6 weeks or longer in AIDS patients.

Usual Adult Dose for Dientamoeba fragilis:

25 to 35 mg/kg/day orally in 3 divided doses with meals for 7 days (unlabeled use).

Usual Adult Dose for Giardiasis:

25 to 35 mg/kg/day orally in 3 divided doses with meals for 7 days (investigational). Paromomycin is an alternative for the treatment of giardiasis. Metronidazole is generally considered the drug of choice.

Usual Adult Dose for Hymenolepis nana (Dwarf Tapeworm):

45 mg/kg orally once a day for 5 to 7 days (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Diphyllobothrium latum (Fish Tapeworm):

1 g orally every 15 minutes for 4 doses (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Dipylidium caninum (Dog Tapeworm):

1 g orally every 15 minutes for 4 doses (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Taenia saginata (beef tapeworm):

1 g orally every 15 minutes for 4 doses (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Taenia solium (pork tapeworm):

1 g orally every 15 minutes for 4 doses (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Hepatic Coma:

Adjunct therapy: 1 gram four times a day for 5 to 7 days

Usual Pediatric Dose for Amebiasis:

<18 years: 25 to 35 mg/kg/day orally in 3 divided doses with meals for 5 to 10 days. Should be used following a course of metronidazole for the treatment of mild to severe, symptomatic disease. Paromomycin is not effective in extraintestinal amebiasis.

Usual Pediatric Dose for Cryptosporidiosis:

25 to 35 mg/kg/day orally in 3 divided doses with meals for 10 to 14 days (investigational). Has occasionally been used for up to 4 to 6 weeks or longer in AIDS patients.

Usual Pediatric Dose for Dientamoeba fragilis:

<18 years: 25 to 35 mg/kg/day orally in 3 divided doses with meals for 7 days (unlabeled use).

Usual Pediatric Dose for Giardiasis:

<18 years: 25 to 35 mg/kg/day orally in 3 divided doses with meals for 7 days (investigational). Paromomycin is an alternative for the treatment of giardiasis. Metronidazole is generally considered the drug of choice.

Usual Pediatric Dose for Hymenolepis nana (Dwarf Tapeworm):

<18 years: 45 mg/kg orally once a day for 5-7 days (unlabeled use).

Usual Pediatric Dose for Diphyllobothrium latum (Fish Tapeworm):

<18 years: 11 mg/kg orally every 15 minutes for 4 doses (unlabeled use).

Usual Pediatric Dose for Dipylidium caninum (Dog Tapeworm):

<18 years: 11 mg/kg orally every 15 minutes for 4 doses (unlabeled use).

Usual Pediatric Dose for Taenia saginata (beef tapeworm):

<18 years: 11 mg/kg orally every 15 minutes for 4 doses (unlabeled use).

Usual Pediatric Dose for Taenia solium (pork tapeworm):

<18 years: 11 mg/kg orally every 15 minutes for 4 doses (unlabeled use).

What other drugs will affect paromomycin?

Other drugs may interact with paromomycin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your pharmacist can provide more information about paromomycin.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 2.01. Revision Date: 2013-11-20, 12:30:09 PM.

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