Natazia Side Effects

Generic name: dienogest / estradiol

Note: This document contains side effect information about dienogest / estradiol. Some of the dosage forms listed on this page may not apply to the brand name Natazia.

Some side effects of Natazia may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to dienogest / estradiol: oral tablet

Get emergency medical help if you have any of these signs of an allergic reaction while taking dienogest / estradiol: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using dienogest and estradiol and call your doctor at once if you have a serious side effect such as:

• sudden numbness or weakness, especially on one side of the body;

• sudden and severe headache, confusion, problems with vision, speech, or balance;

• chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

• sudden cough, wheezing, rapid breathing, coughing up blood;

• pain, swelling, warmth, or redness in one or both legs;

• a change in the pattern or severity of migraine headaches;

• nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

• swelling in your hands, ankles, or feet;

• a breast lump; or

• symptoms of depression (sleep problems, weakness, tired feeling, mood changes).

Less serious side effects of dienogest / estradiol may include:

• mild nausea (especially when you first start taking this medicine), vomiting, bloating, stomach cramps;

• breast pain or tenderness;

• freckles or darkening of facial skin, acne;

• weight gain;

• problems with contact lenses;

• vaginal itching or discharge, very light menstrual periods; or

• decreased sex drive.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to dienogest / estradiol: oral tablet

Cardiovascular

Cardiovascular side effects have included venous thromboembolism, cerebrovascular events (thrombotic and hemorrhagic strokes), and myocardial infarctions.

Hepatic

Hepatic side effects have included jaundice, hepatic adenomas, cholestasis, focal nodular hyperplasia of the liver and hepatic carcinoma.

Genitourinary

Genitourinary side effects have included irregular uterine bleeding, breast pain, discomfort or tenderness, metrorrhagia and irregular menstruation, uterine leiomyoma, and ruptured ovarian cyst.

Gastrointestinal

Gastrointestinal side effects have included nausea and/or vomiting.

Nervous system

Nervous system side effects have included headache and migraine.

Dermatologic

Dermatologic side effects have included acne.

General

General side effects have included weight gain.

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