Levorphanol Side Effects

Brand Names: Levo-Dromoran

Please note - some side effects for Levorphanol may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Levorphanol - for the Consumer

Levorphanol

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Levorphanol:

Altered mood and thoughts; constipation; dizziness; drowsiness; flushing; nausea; reaction or pain at the injection site; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur when using Levorphanol:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); depression; difficulty urinating; fainting; fast, slow, or irregular heartbeat; itching; seizures.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Levorphanol Tablets

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Levorphanol Tablets:

Altered mood and thoughts; constipation; dizziness; drowsiness; flushing; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur when using Levorphanol Tablets:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); depression; difficulty urinating; fainting; fast, slow, or irregular heartbeat; itching; seizures.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

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Levorphanol Side Effects - for the Professional

Levorphanol

In approximately 1400 patients treated with Levorphanol in controlled clinical trials, the type and incidence of side effects were those expected of an opioid analgesic, and no unforeseen or unusual toxicity was reported.

Drugs of this type are expected to produce a cluster of typical opioid effects in addition to analgesia, consisting of nausea, vomiting, altered mood and mentation, pruritus, flushing, difficulties in urination, constipation, and biliary spasm. The frequency and intensity of these effects appears to be dose related. Although listed as adverse events these are expected pharmacologic actions of these drugs and should be interpreted as such by the clinician.

The following adverse events have been reported with the use of Levorphanol:

Body as a Whole: abdominal pain, dry mouth, sweating

Cardiovascular System: cardiac arrest, shock, hypotension, arrhythmias including bradycardia and tachycardia, palpitations, extra-systoles

Digestive System: nausea, vomiting, dyspepsia, biliary tract spasm

Nervous System: coma, suicide attempt, convulsions, depression, dizziness, confusion, lethargy, abnormal dreams, abnormal thinking, nervousness, drug withdrawal, hypokinesia, dyskinesia, hyperkinesia, CNS stimulation, personality disorder, amnesia, insomnia

Respiratory System: apnea, cyanosis, hypoventilation

Skin & Appendages: pruritus, urticaria, rash, injection site reaction

Special Senses: abnormal vision, pupillary disorder, diplopia

Urogenital System: kidney failure, urinary retention, difficulty urinating

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Side Effects by Body System - for Healthcare Professionals

General

The adverse effects of levorphanol are generally similar to the adverse effects observed with other narcotic analgesics.

Nervous system

Opiates may result in psychotic symptoms in some patients.

Nervous system side effects include mental and respiratory depression, stupor, delirium, somnolence, and dysphoria.

Other

Other side effects including withdrawal symptoms after either abrupt cessation or fast tapering of narcotic analgesics may occur and include agitation, restlessness, anxiety, insomnia, tremor, abdominal cramps, blurred vision, vomiting and sweating.

Cardiovascular

Cardiovascular adverse effects include hypotension and arrhythmias rarely.

Gastrointestinal

Gastrointestinal side effects including nausea, vomiting, and constipation are relatively common effects of narcotic analgesics.

Genitourinary

Genitourinary side effects including urinary retention has been reported for other narcotic analgesics.

Dermatologic

Dermatologic side effects including rashes have been reported rarely. Narcotic induced rashes may be related to direct stimulation of histamine release.

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