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Isovue-128 Side Effects

Generic Name: iopamidol

Note: This page contains information about the side effects of iopamidol. Some of the dosage forms included on this document may not apply to the brand name Isovue-128.

Not all side effects for Isovue-128 may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to iopamidol: injection solution

In addition to its needed effects, some unwanted effects may be caused by iopamidol (the active ingredient contained in Isovue-128). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking iopamidol, check with your doctor or nurse immediately:

Less common
  • Arm, back, or jaw pain
  • blurred vision
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast or irregular heartbeat
  • feeling of warmth
  • hives
  • lightheadedness, dizziness, or fainting
  • nausea
  • redness of the face, neck, arms, and occasionally, upper chest
  • shortness of breath
  • slow or irregular heartbeat
  • sudden sweating
  • unusual tiredness or weakness
Less common or rare
  • Blue lips and fingernails
  • changes in skin color
  • chills
  • coughing that sometimes produces a pink frothy sputum
  • decrease in the frequency of urination
  • decrease in urine volume
  • difficult, fast, noisy breathing, sometimes with wheezing
  • difficulty in passing urine (dribbling)
  • dizziness
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • headache
  • hives or welts, itching, or skin rash
  • increased sweating
  • nervousness
  • numbness or tingling in the face, arms, or legs
  • pain or discomfort in the arms, jaw, back, or neck
  • pain, tenderness, or swelling of the foot or leg
  • painful urination
  • pale skin
  • pounding in the ears
  • redness of the skin
  • severe, unusual tiredness or weakness
  • trouble speaking, thinking, or walking
  • vomiting
  • Double vision
  • inability to move the arms, legs, or facial muscles
  • pain in the chest, groin, or legs, especially the calves
  • severe, sudden headache
  • slow speech
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sudden, unexplained shortness of breath
  • vision changes
Incidence not known
  • Change in consciousness
  • heart stops
  • loss of consciousness
  • no breathing
  • no pulse or blood pressure
  • no sensation in the legs
  • not able to pass urine
  • pain, redness, or pale skin at the injection site
  • seizures
  • unable to move the legs

Some of the side effects that can occur with iopamidol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common or rare
  • Bad, unusual, or unpleasant (after) taste
  • change in taste
  • discouragement
  • disturbed color perception
  • feeling sad or empty
  • halos around lights
  • irritability
  • loss of appetite
  • loss of interest or pleasure
  • loss of vision
  • night blindness
  • overbright appearance of lights
  • stuffy nose
  • trouble concentrating
  • trouble sleeping
  • tunnel vision
  • weight loss
Incidence not known
  • Abdominal or stomach cramps
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • burning, dry, or itching eyes
  • discharge or excessive tearing
  • general feeling of discomfort or illness
  • loss of memory
  • problems with memory
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • runny nose
  • sneezing
  • trembling or shaking of the hands or feet

For Healthcare Professionals

Applies to iopamidol: injectable solution, intrathecal solution


The most commonly reported adverse reactions after oral administration of this drug are vomiting and diarrhea.
If administered intrathecally, the most frequently reported adverse reactions are headache, nausea, vomiting, and musculoskeletal pain . These reactions are usually mild to moderate, occur 1 to 10 hours after injection (almost all occurring within 24 hours), and usually disappearing within 24 hours.[Ref]


Very common (10% or more): Nausea
Common (1% to 10%): Vomiting
Uncommon (0.1% to 1%): Anorexia, diarrhea, abdominal discomfort, dry mouth
Frequency not reported:Severe retching and choking, abdominal cramps (may occur as a consequence of the procedure), salivary hypersecretion, salivary gland enlargement, rectal hemorrhage, dysphagia, heartburn[Ref]


Common (1% to 10%): Extrasystoles, atrial fibrillation, ventricular tachycardia, ventricular fibrillation
Uncommon (0.1% to 1%): Tachycardia, hypotension, hypertension, myocardial ischemia, circulatory collapse, ST-segment depression bigeminy extrasystoles, angina pectoris, bradycardia, transient ischemic attack, thrombophlebitis, flushing, bradycardia
Frequency not reported: Arterial spasm, vasodilation, chest pain, cardiopulmonary arrest, myocardial infarction, arterial thrombosis, displacement of arterial plaques, venous thrombosis, dissection of the coronary vessels, transient sinus arrest, cerebral hematomas, petechiae, cardiorespiratory arrest, pallor, electrocardiogram change including ST segment depression, cyanosis, syncope[Ref]

Nervous system

Common (1% to 10%): Pain (2.8%), burning sensation (1.4%)
Uncommon (0.1% to 1%): Vasovagal reaction, tingling in arms, grimace, faintness, headache, taste alterations
Rare (less than 0.1%): Paresthesia
Frequency not reported: Dizziness, temporary cortical blindness, temporary amnesia, convulsions, paralysis, coma, depressed level of consciousness or loss of consciousness, restlessness, meningismus, meningitis like reaction, meningitis, agitation, abnormal coordination, involuntary movements, paraplegia, encephalopathy, hypoesthesia, somnolence, numbness, emotional stress, motor seizures, facial neuralgia, drowsiness[Ref]


Common (1% to 10%): Hot flashes (1.5%), warmth (1.1%)
Uncommon (0.1% to 1%): Fever, chills, feeling cold
Frequency not reported: Tremors, malaise, pain, rigors, shivering, hypothermia, tinnitus[Ref]


Uncommon (0.1% to 1%): Rash, urticaria, pruritus, excessive sweating, erythema
Very rare (less than 0.01%): Muco-cutaneous syndromes, including Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome), erythema multiforme, inflammation, skin necrosis
Frequency not reported: Erythematous swelling, facial edema, skin necrosis, bullous eruption, exanthema, skin cold/clammy[Ref]


Uncommon (0.1% to 1%): Urinary retention
Frequency not reported: Urogenital pain, hematuria, osmotic nephrosis of proximal tubular cells, neurogenic bladder[Ref]


Uncommon (0.1% to 1%): Back spasm, back pain
Rare (less than 0.1%): Muscle spasm
Frequency not reported: Involuntary leg movement, musculoskeletal pain, musculoskeletal weakness muscle cramps, myalgia, myopathy, backache, neck stiffness, leg sciatic pain, radicular irritation,cold extremities, shoulder pain, leg cramps[Ref]


Uncommon (0.1% to 1%): Visual disturbances
Frequency not reported: Periorbital edema, watery itchy eyes, lacrimation, conjunctivitis, conjunctival chemosis with infection, transient blindness, photophobia, mydriasis, oculogyric crisis[Ref]


Uncommon (0.1% to 1%): Acute renal failure
Frequency not reported: Abnormal renal function, transient changes in hepatorenal chemistry tests[Ref]


Uncommon (0.1% to 1%): Throat constriction, dyspnea, pulmonary edema, nasal congestions, asthma, bronchospasm
Frequency not reported: Increased cough, sneezing, asthma, apnea, laryngeal edema, chest tightness/pain, rhinitis, brachial plexus palsy following axillary artery injections, respiratory arrest, respiratory failure, acute respiratory distress syndrome, Apnea Laryngeal edema, pharyngitis[Ref]


Frequency not reported: Thyroid function tests indicative of hypothyroidism or transient thyroid suppression in adults and pediatric patients (including infants)[Ref]


Frequency not reported: Neutropenia, thrombocytopenia[Ref]


Frequency not reported: Anaphylactoid reaction (characterized by cardiovascular, respiratory and cutaneous symptoms), anaphylaxis reaction[Ref]


Frequency not reported: Injection site pain usually due to extravasation, hemorrhage or pseudoaneurysms at the puncture site[Ref]


Frequency not reported: Confusion, paroniria, hallucinations[Ref]


1. "Product Information. Isovue-M-200 (iopamidol)." Bracco Diagnostics Inc, Princeton, NJ.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

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