Hydrocodone Side Effects

Not all side effects for hydrocodone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to hydrocodone: oral capsule extended release, oral liquid, oral syrup, oral tablet

In addition to its needed effects, some unwanted effects may be caused by hydrocodone. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking hydrocodone:

Less common
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • body aches or pain
  • chills
  • cough
  • depression
  • difficult or labored breathing
  • ear congestion
  • fear or nervousness
  • fever
  • headache
  • loss of voice
  • nasal congestion
  • rapid weight gain
  • runny nose
  • sneezing
  • sore throat
  • tightness in the chest
  • tingling of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss

If any of the following symptoms of overdose occur while taking hydrocodone, get emergency help immediately:

Symptoms of overdose
  • Blue lips and fingernails
  • blurred vision
  • change in consciousness
  • chest pain or discomfort
  • cold and clammy skin
  • confusion
  • constricted pupil (black part of the eye)
  • coughing that sometimes produces a pink frothy sputum
  • decreased awareness or responsiveness
  • difficult, fast, noisy breathing, sometimes with wheezing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • increased sweating
  • irregular, fast or slow, or shallow breathing
  • lightheadedness, dizziness, or fainting
  • loss of consciousness
  • no muscle tone or movement
  • pale skin
  • severe sleepiness
  • sleepiness or unusual drowsiness
  • slow or irregular heartbeat

Some of the side effects that can occur with hydrocodone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Difficulty having a bowel movement (stool)
  • nausea
Less common
  • Abdominal or stomach pain or discomfort
  • back pain
  • bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • dry mouth
  • frequent urge to urinate
  • heartburn
  • itching skin
  • lower back or side pain
  • muscle spasms
  • vomiting

For Healthcare Professionals

Applies to hydrocodone: compounding powder, oral capsule extended release

Dermatologic

Common (1% to 10%): Pruritus (3%), skin laceration (1 to 10%), hyperhidrosis (1 to 10%), night sweats (1 to 10%), rash (1 to 10%)

Endocrine

Common (1 to 10%): Hot flush (1 to 10%)

Gastrointestinal

Very common (10% or more): Constipation (8 to 11%), nausea (7 to 10%)
Common (1% to 10%): Dry mouth (3%), vomiting (3 to 5%), abdominal pain or discomfort (2 to 3%), gastroesophageal reflux disease (1 to 10%)

General

Common (1% to 10%): Peripheral edema (1 to 3%), noncardiac chest pain (1 to 10%), pain (1 to 10%), pyrexia (1 to 10%), dehydration (1 to 10%), hypokalemia (1 to 10%)

Genitourinary

Common (1% to 10%): Urinary tract infection (1 to 5%)

Hematologic

Common (1 to 10%): Increased blood cholesterol (1 to 10%)

Hepatic

Common (1 to 10%): Increased glutamyltransferase (1 to 10%)

Musculoskeletal

Common (1% to 10%): Back pain (1 to 4%), muscle spasms (1 to 3%), contusion (1 to 10%), fall (1 to 10%), foot fracture (1 to 10%)joint injury or sprain (1 to 10%), muscle strain (1 to 10%), arthralgia (1 to 10%), musculoskeletal pain (1 to 10%), myalgia (1 to 10%), neck pain (1 to 10%), osteoarthritis (1 to 10%), pain in extremity (1 to 10%)

Nervous system

Common (1% to 10%): Somnolence (1 to 5%), fatigue (1 to 4%), headache (4%), tremor (3%), dizziness (2 to 3%), lethargy (1 to 10%), migraine (1 to 10%), paresthesia (1 to 10%)

Psychiatric

Common (1 to 10%): Anxiety (1 to 10%), depression (1 to 10%), insomnia (1 to 10%)

Respiratory

Common (1% to 10%): Upper respiratory tract infection (1 to 3%), cough (1 to 10%), dyspnea (1 to 10%)

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web2)