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Glimepiride Side Effects

Not all side effects for glimepiride may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to glimepiride: oral tablet

In addition to its needed effects, some unwanted effects may be caused by glimepiride. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking glimepiride:

  • Difficulty with swallowing
  • dizziness
  • fast heartbeat
  • hives
  • itching
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shortness of breath
  • skin rash
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing
Incidence not known
  • Abdominal or stomach pain
  • agitation
  • back, leg, or stomach pains
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • bloating of abdomen
  • blood in the urine or stools
  • bloody, black, or tarry stools
  • chest pain
  • chills
  • coma
  • confusion
  • cough or hoarseness
  • dark urine
  • decreased urine output
  • depression
  • diarrhea
  • difficulty with breathing
  • fever with or without chills
  • fluid-filled skin blisters
  • general body swelling
  • general tiredness and weakness
  • headache
  • high fever
  • hostility
  • irritability
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lethargy
  • light-colored stools
  • loss of appetite
  • lower back or side pain
  • muscle twitching
  • nausea and vomiting
  • nosebleeds
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • red, irritated eyes
  • red skin lesions, often with a purple center
  • seizures
  • sensitivity to the sun
  • skin thinness
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stupor
  • swelling of face, ankles, or hands
  • swollen or painful glands
  • unusual bleeding or bruising
  • upper right abdominal or stomach pain
  • yellow eyes or skin

If any of the following symptoms of overdose occur while taking glimepiride, get emergency help immediately:

Symptoms of overdose
  • Anxiety
  • blurred vision
  • cold sweats
  • cool, pale skin
  • increased hunger
  • nightmares
  • shakiness
  • slurred speech

Some of the side effects that can occur with glimepiride may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Lack or loss of strength
Incidence not known
  • Redness or other discoloration of the skin
  • severe sunburn

For Healthcare Professionals

Applies to glimepiride: oral tablet


The administration of oral hypoglycemic drugs has been associated with increased cardiovascular mortality as compared to treatment with diet alone or diet plus insulin. This warning is based on a study of 823 patients, which reported that patients treated for 5 to 8 years with diet plus a fixed dose of tolbutamide (1.5 G per day) had a rate of cardiovascular mortality approximately 2.5 times that of patients treated with diet alone. Although only one drug in the sulfonylurea class (tolbutamide) was included in this study, this warning may also apply to other drugs in this class in view of their close similarities in mode of action and chemical structure.[Ref]

Cardiovascular side effects have included reports of increased mortality with some sulfonylurea agents, however, no such data exists for glimepiride.[Ref]


Metabolic side effects have included hypoglycemia (blood sugars less than 60 mg/dl) in 0.9% to 1.7%. Hyponatremia occurred rarely. The syndrome of inappropriate antidiuretic hormone (SIADH) secretion, hepatic porphyria reactions, and disulfiram reactions have also been reported.[Ref]

Nervous system

Nervous system side effects have included dizziness (1.7%), asthenia (1.6%), and headache (1.5%).[Ref]


Ocular side effects have included blurred vision and loss of accommodation in less than 1% of treated patients.[Ref]


Dermatologic side effects have included pruritus, erythema, urticaria, and morbilliform or maculopapular rashes in less than 1% of cases. Sulfonylureas have caused porphyria cutanea tarda and photosensitivity reactions.[Ref]


Gastrointestinal side effects have included nausea (1.1%). Vomiting, diarrhea, and pain were noted in less than 1% of cases.[Ref]


Hematologic side effects have included leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia, and pancytopenia. Postmarketing reports include severe cases of thrombocytopenia with platelet count less than 10,000/uL and thrombocytopenic purpura.[Ref]


Hepatic side effects have included cholestatic jaundice with other sulfonylureas. However, no data exists for glimepiride.[Ref]


Hypersensitivity side effects have included allergic skin reactions, e.g., pruritus, erythema, urticaria, and morbilliform or maculopapular eruptions, which occurred in less than 1% of treated patients. Some of these were transient and disappeared despite continued use of glimepiride. Allergic vasculitis has also been reported. Additional reports included hypersensitivity reactions worsening: such as dyspnea, fall in blood pressure, and shock.[Ref]


1. "Product Information. Amaryl (glimepiride)." Hoechst Marion-Roussel Inc, Kansas City, MO.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.