Glimepiride Dosage

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Usual Adult Dose for:

Usual Geriatric Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Diabetes Type 2

Initial dose: 1 to 2 mg orally once a day.
Maintenance dose: 1 to 4 mg orally once a day.
Glimepiride should be administered with breakfast or the first main meal. Maximum recommended dose is 8 mg per day.

Usual Geriatric Dose for Diabetes Type 2

Initial dose: 1 mg orally once a day.
Maintenance dose: 1 to 4 mg orally once a day.

Usual Pediatric Dose for Diabetes Type 2

>8 years:
Initial dose: 1 to 2 mg orally once a day.
Maintenance dose: 1 to 4 mg orally once a day.
Glimepiride should be administered with breakfast or the first main meal. Maximum recommended dose is 8 mg per day.

Renal Dose Adjustments

CrCl < 30 mL/min: Initial dose: 1 mg orally once a day.
Maintenance dose: 1 to 4 mg orally once a day.

Liver Dose Adjustments

After reaching a dose of 2 mg, dosage increases should be made in increments of no more than 2 mg at 1 or 2 week intervals. Glimepiride should be used with caution in patients with hepatic insufficiency.

Dialysis

Data not available

Other Comments

Administration advice: Glimepiride should be administered at least 4 hours prior to colesevelam to ensure that colesevelam does not reduce the absorption of glimepiride.

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