Glimepiride / pioglitazone Side Effects
Some side effects of glimepiride / pioglitazone may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to glimepiride / pioglitazone: oral tablet
Along with its needed effects, glimepiride / pioglitazone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking glimepiride / pioglitazone:More common
- bladder pain
- bloody or cloudy urine
- blurred vision
- cold sweats
- cool, pale skin
- difficult, burning, or painful urination
- fast heartbeat
- frequent urge to urinate
- increased hunger
- increased weight
- lower back or side pain
- slurred speech
- swelling of the feet or lower legs
- unusual tiredness or weakness
- Accidental injury
- loss of appetite
- pain or swelling in the arms or legs without any injury
- pale skin
- stomach pain
- troubled breathing with exertion
- unusual bleeding or bruising
- weight loss
- yellow eyes or skin
Some side effects of glimepiride / pioglitazone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Body aches or pain
- difficulty with moving
- dryness or soreness of the throat
- ear congestion
- joint pain
- loss of voice
- muscle aching or cramping
- muscle pains or stiffness
- runny nose
- stuffy nose
- swollen joints
- tender, swollen glands in the neck
- tooth disorder
- trouble with swallowing
- voice changes
- itching skin
- lack or loss of strength
- skin rash
For Healthcare Professionals
Applies to glimepiride / pioglitazone: oral tablet
Cardiovascular side effects have included edema, lower limb edema, and peripheral edema.
Hepatic side effects have included cholestasis, jaundice, and hepatitis which has lead to liver failure.
Endocrine side effects have included hypoglycemia and aggravation of diabetes mellitus.
Metabolic side effects have included hepatic porphyria reactions and disulfiram-like reactions. Hyponatremia, increased release of antidiuretic hormone, and the syndrome of inappropriate antidiuretic hormone (SIADH) secretion have been reported.
Respiratory side effects have included upper respiratory tract infection and pharyngitis.
Hematologic side effects have included leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia, and pancytopenia.
Gastrointestinal side effecys have included vomiting, gastrointestional pain, diarrhea, and nausea.
Nervous system side effects have included headache, dizziness, and limb pain.
Musculoskeletal side effects have included myalgia and asthenia.
Dermatologic side effects have included allergic skin reactions, pruritus, erythema, urticaria, morbilliform and maculopapular eruptions. Porphyria cutanea tarda, photosensitivity reactions, and allergic vasculitis have been reported.
Genitourinary side effects have included urinary tract infection.
General side effects have included weight gain, tooth disorder, and accidental injury.
Ocular side effects have included changes in accommodation and blurred vision.
Macular edema has been reported in postmarketing experience in diabetic patients who were taking pioglitazone or another thiazolidinedione. Some patients presented with blurred vision or decreased visual acuity, but some patients appear to have been diagnosed on routine ophthalmologic examination. Some patients had peripheral edema at the time macular edema was diagnosed. Some patients had improvement in their macular edema after discontinuation of their thiazolidinedione. It is unknown whether or not there is a causal relationship between pioglitazone and macular edema. Patients with diabetes should have regular eye exams by an ophthalmologist, per the Standards of Care of the American Diabetes Association. Additionally, any diabetic who reports any kind of visual symptom should be promptly referred to an ophthalmologist, regardless of the patient's underlying medications or other physical findings.
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