Skip to Content

Glimepiride / pioglitazone Side Effects

Not all side effects for glimepiride / pioglitazone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to glimepiride / pioglitazone: oral tablet

In addition to its needed effects, some unwanted effects may be caused by glimepiride / pioglitazone. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking glimepiride / pioglitazone:

More common
  • Anxiety
  • bladder pain
  • bloody or cloudy urine
  • blurred vision
  • chills
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • depression
  • difficult, burning, or painful urination
  • fast heartbeat
  • frequent urge to urinate
  • headache
  • increased hunger
  • increased weight
  • lower back or side pain
  • nausea
  • nightmares
  • seizures
  • shakiness
  • slurred speech
  • swelling of the feet or lower legs
  • unusual tiredness or weakness
Less common
  • Accidental injury
  • loss of appetite
  • pain or swelling in the arms or legs without any injury
  • pale skin
  • stomach pain
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • vomiting
  • weight loss
  • yellow eyes or skin

Some of the side effects that can occur with glimepiride / pioglitazone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Body aches or pain
  • cough
  • diarrhea
  • difficulty with moving
  • dryness or soreness of the throat
  • ear congestion
  • fever
  • hoarseness
  • joint pain
  • loss of voice
  • muscle aching or cramping
  • muscle pains or stiffness
  • runny nose
  • sneezing
  • stuffy nose
  • swollen joints
  • tender, swollen glands in the neck
  • tooth disorder
  • trouble swallowing
  • voice changes
Less common
  • Dizziness
  • itching skin
  • lack or loss of strength
  • skin rash

For Healthcare Professionals

Applies to glimepiride / pioglitazone: oral tablet


Cardiovascular side effects have included edema, lower limb edema, and peripheral edema.[Ref]


Hepatic side effects have included cholestasis, jaundice, and hepatitis which has lead to liver failure.[Ref]


Endocrine side effects have included hypoglycemia and aggravation of diabetes mellitus.[Ref]


Metabolic side effects have included hepatic porphyria reactions and disulfiram-like reactions. Hyponatremia, increased release of antidiuretic hormone, and the syndrome of inappropriate antidiuretic hormone (SIADH) secretion have been reported.[Ref]


Respiratory side effects have included upper respiratory tract infection and pharyngitis.[Ref]


Hematologic side effects have included leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia, and pancytopenia.[Ref]


Gastrointestinal side effecys have included vomiting, gastrointestional pain, diarrhea, and nausea.[Ref]

Nervous system

Nervous system side effects have included headache, dizziness, and limb pain.[Ref]


Musculoskeletal side effects have included myalgia and asthenia.[Ref]


Dermatologic side effects have included allergic skin reactions, pruritus, erythema, urticaria, morbilliform and maculopapular eruptions. Porphyria cutanea tarda, photosensitivity reactions, and allergic vasculitis have been reported.[Ref]


Genitourinary side effects have included urinary tract infection.[Ref]


General side effects have included weight gain, tooth disorder, and accidental injury.[Ref]


Ocular side effects have included changes in accommodation and blurred vision.[Ref]

Macular edema has been reported in postmarketing experience in diabetic patients who were taking pioglitazone or another thiazolidinedione. Some patients presented with blurred vision or decreased visual acuity, but some patients appear to have been diagnosed on routine ophthalmologic examination. Some patients had peripheral edema at the time macular edema was diagnosed. Some patients had improvement in their macular edema after discontinuation of their thiazolidinedione. It is unknown whether or not there is a causal relationship between pioglitazone and macular edema. Patients with diabetes should have regular eye exams by an ophthalmologist, per the Standards of Care of the American Diabetes Association. Additionally, any diabetic who reports any kind of visual symptom should be promptly referred to an ophthalmologist, regardless of the patient's underlying medications or other physical findings.[Ref]


1. "Product Information. Duetact (glimepiride-pioglitazone)." Takeda Pharmaceuticals America, Lincolnshire, IL.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.