Glimepiride / pioglitazone Pregnancy and Breastfeeding Warnings

Glimepiride / pioglitazone is also known as: Duetact

Glimepiride / pioglitazone Pregnancy Warnings

Glimepiride has been assigned to pregnancy category C by the FDA. Animal studies of glimepiride have revealed evidence of fetotoxicity, most likely a result of maternal hypoglycemia. There are no controlled data in human pregnancy. Animal studies of pioglitazone have not revealed evidence of teratogenicity. Delayed parturition and embryotoxicity were observed in both rats and rabbits. The manufacturer states that glimepiride-pioglitazone should not be used during pregnancy. Glimepiride-pioglitazone is generally considered contraindicated during pregnancy and is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.

Glimepiride / pioglitazone Breastfeeding Warnings

There are on data on the excretion of glimepiride or pioglitazone into human milk. Other sulfonylureas are excreted into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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