Glimepiride / Pioglitazone Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Diabetes Type 2

The initial dosage of glimepiride recommended for this patient with diabetes mellitus type II is based on the patient's current regime of pioglitazone and /or sulfonylurea.

For patients currently on glimepiride monotherapy, glimepiride-pioglitazone may be initiated at 30 mg/2 mg or 30 mg/4 mg tablet strengths once daily, and adjusted after assessing adequacy of therapeutic response.

For patients currently on pioglitazone monotherapy, glimepiride-pioglitazone may be initiated at 30 mg-2 mg or 30 mg-4 mg tablet strengths once daily, and adjusted after assessing adequacy of therapeutic response.

For patients currently on a different sulfonylurea monotherapy or switching from combination therapy of pioglitazone plus a different sulfonylurea (e.g. glyburide, glipizide, chlorpropamide, tolbutamide, acetohexamide), glimepiride-pioglitazone should be limited initially to a starting dose of 30 mg/2 mg once daily, and adjusted after assessing adequacy of therapeutic response.

For patients switching from combination therapy of pioglitazone plus glimepiride as separate tablets, glimepiride-pioglitazone may be initiated with 30 mg/2 mg or 30 mg/4 mg tablet strengths based on the dose of pioglitazone and glimepiride already being taken. Patients who are not controlled with 15 mg of pioglitazone in combination with glimepiride should be carefully monitored when switched to glimepiride-pioglitazone.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Therapy with glimepiride-pioglitazone should not be initiated if the patient exhibits clinical evidence of active liver disease or increased serum transaminase levels (ALT greater than 2.5 times the upper limit of normal) at start of therapy.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

Glimepiride-pioglitazone should be taken once daily with the first main meal. Glimepiride-pioglitazone should not be given more than once daily for any of the tablet strengths.

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