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Econazole topical Side Effects

For the Consumer

Applies to econazole topical: topical cream, topical foam, topical powder, topical solution

In addition to its needed effects, some unwanted effects may be caused by econazole topical. In the event that any of these side effects do occur, they may require medical attention.

Severity: Major

You should check with your doctor immediately if any of these side effects occur when taking econazole topical:

Less common:
  • Burning, itching, stinging, redness, or other sign of irritation at the application site
  • rash

For Healthcare Professionals

Applies to econazole topical: compounding powder, topical cream, topical foam


One patient developed erythematous, edematous, urticarial-like lesions with vesiculation at the site of econazole application. Sensitivity to econazole was confirmed by patch testing.[Ref]

Common (1% to 10%): Erythema (about 3%), stinging (about 3%), itching (about 3%), burning (about 3%)
Rare (less than 0.1%): Lesions with vesiculation at site of application (at least 1 case)

Uncommon (0.1% to 1%): Application site reactions[Ref]


Frequency not reported: Sensitivity to econazole


Rare (less than 0.1%): Pruritic rash (at least 1 case)


1. Millikan LE, Galen WK, Gewirtzman GB, Horwitz SN, Landow RK, Nesbitt LT Jr, Roth HL, Sefton J, Day RM "Naftifine cream 1% versus econazole cream 1% in the treatment of tinea cruris and tinea corporis." J Am Acad Dermatol 18 (1988): 52-6

2. Heel RC, Brogden RN, Speight TM, Avery GS "Econazole: a review of its antifungal activity and therapeutic efficacy." Drugs 16 (1978): 177-201

3. Valsecchi R, Tornaghi A, Tribbia G, Cainelli T "Contact dermatitis from econazole." Contact Dermatitis 8 (1982): 422

4. "Product Information. Spectazole (econazole)." Ortho Pharmaceutical Corporation, Raritan, NJ.

Not all side effects for econazole topical may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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