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ciclopirox topical

Generic Name: ciclopirox topical (sye kloe PEER ox TOP i kal)
Brand Name: Ciclodan, Ciclodan Kit, CNL8 Nail, Loprox, Pedipirox-4, Penlac Nail Lacquer, Loprox TS

What is ciclopirox topical?

Ciclopirox is an antifungal medication. Ciclopirox topical prevents fungus from growing.

Ciclopirox topical (for the skin) cream, gel, and lotion formulations are used to treat skin infections such as athlete's foot, jock itch, ringworm, and yeast infections.

Ciclopirox shampoo is used to treat seborrheic dermatitis (inflammatory skin condition) of the scalp.

Ciclopirox nail lacquer is used to treat fungal infections of the toenails and fingernails.

Ciclopirox topical may also be used for purposes not listed in this medication guide.

What is the most important information I should know about ciclopirox topical?

You should not use ciclopirox topical if you are allergic to it.

Avoid getting this medication in your eyes, nose, or mouth. If this does happen, rinse with water.

Do not use bandages or dressings that do not allow air to circulate (occlusive dressings) on areas treated with ciclopirox cream or lotion, unless otherwise directed by your doctor. Wear loose-fitting clothing (preferably cotton).

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Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.

What should I discuss with my healthcare provider before using ciclopirox topical?

You should not use ciclopirox if you are allergic to it.

To make sure you can safely use ciclopirox, tell your doctor if you have other medical conditions, especially:

  • diabetes;

  • epilepsy or other seizure disorder;

  • a weak immune system (caused by disease or by using certain medicines).

FDA pregnancy category B. Ciclopirox topical is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether ciclopirox topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use ciclopirox topical?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Wash your hands before and after using this medication, unless you are using ciclopirox to treat a hand condition.

To apply the cream, gel, or lotion:

  • Clean and dry the affected area. Apply a small amount of the cream (usually twice daily) for 2 to 4 weeks. Follow your doctor's instructions.

  • Do not use bandages or dressings that do not allow air to circulate (occlusive dressings) on areas treated with ciclopirox cream or lotion, unless otherwise directed by your doctor. Wear loose-fitting clothing (preferably cotton).

  • If the infection does not clear up in 4 weeks, or if it appears to get worse, see your doctor.

To use ciclopirox shampoo:

  • Wet the hair and apply approximately 1 teaspoon (5 mL) of the shampoo to the scalp. Up to 2 teaspoons (10 mL) may be used for long hair. Lather and leave on the hair and scalp for 3 minutes. A timer may be used. Rinse off the shampoo after 3 minutes have passed.

  • Treatment should be repeated twice per week for 4 weeks, with a minimum of 3 days between applications. If no improvement is seen after 4 weeks of treatment, contact your doctor.

It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve, or if they get worse while using ciclopirox.

To use ciclopirox nail lacquer:

  • Use on the nails and immediately surrounding skin only. Avoid contact with other areas. Remove any loose nail or nail material using nail clippers or a nail file.

  • Apply ciclopirox nail lacquer once daily (preferably at bedtime) to all affected nails with the applicator brush provided. Apply the lacquer evenly over the entire nail. Where possible, apply the nail lacquer to the underside of the nail and to the skin beneath it. Allow the lacquer to dry (approximately 30 seconds) before putting on socks or stockings. After applying the medication, wait 8 hours before taking a bath or shower.

  • Apply ciclopirox nail lacquer daily over the previous coat. Once a week, remove the nail lacquer with alcohol. Remove as much as possible of the damaged nail using nail clippers or nail a file.

  • To prevent the screw cap from sticking to the bottle, do not allow the solution to get into the bottle treads. To prevent the solution from drying out, close the bottle tightly after every use.

Treatment with ciclopirox nail lacquer may require several months before initial improvement of symptoms is noticed. Up to 48 weeks of daily application of the nail lacquer, monthly removal of the unattached infected nail by a health care professional, and weekly trimming by the patient may be required for complete treatment.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.

Store all forms of this medication at room temperature away from moisture and heat. Once a bottle of ciclopirox shampoo is opened, it should be used within 8 weeks.

Ciclopirox nail lacquer is flammable. Avoid using near open flame, and do not smoke until the gel has completely dried on your skin.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

An overdose of ciclopirox topical is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while using ciclopirox topical?

Avoid contact with the eyes, nose, and inside of the mouth. If this does happen, rinse with water.

Avoid using other medications on the areas you treat with ciclopirox topical unless your doctor tells you to.

Do not use nail polish, artificial nails, or other cosmetic nail products on the nails treated with ciclopirox nail lacquer.

Avoid wearing tight-fitting, synthetic clothing that doesn't allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until the infection is healed.

Ciclopirox topical side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using ciclopirox and call your doctor at once if you have a serious side effect such as:

  • unusual or severe itching, redness, burning, dryness, or irritation of treated skin; or

  • discoloration or other changes in the nails.

Less serious side effects may include mild burning, itching, or redness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Ciclopirox topical dosing information

Usual Adult Dose for Onychomycosis -- Fingernail:

8% topical solution: Apply once a day (preferably at bedtime or 8 hours before washing) to all affected nails with the applicator brush provided. Apply evenly over the entire nail plate and 5 mm of surrounding skin. If possible, the solution should be applied to the nail bed, hyponychium, and the under surface of the nail plate when it is free of the nail bed.

The product should not be removed on a daily basis. Daily applications should be made over the previous coat and removed with alcohol every 7 days. This cycle should be repeated throughout the duration of treatment.

Up to 48 weeks of daily applications and professional removal, as frequently as monthly, of the unattached, infected nail are considered the full treatment to achieve a clear or almost clear nail. Six months of therapy with professional removal of the unattached, infected nail may be required before initial improvement of symptoms is noticed.

Usual Adult Dose for Onychomycosis -- Toenail:

8% topical solution: Apply once a day (preferably at bedtime or 8 hours before washing) to all affected nails with the applicator brush provided. Apply evenly over the entire nail plate and 5 mm of surrounding skin. If possible, the solution should be applied to the nail bed, hyponychium, and the under surface of the nail plate when it is free of the nail bed.

The product should not be removed on a daily basis. Daily applications should be made over the previous coat and removed with alcohol every 7 days. This cycle should be repeated throughout the duration of treatment.

Up to 48 weeks of daily applications and professional removal, as frequently as monthly, of the unattached, infected nail are considered the full treatment to achieve a clear or almost clear nail. Six months of therapy with professional removal of the unattached, infected nail may be required before initial improvement of symptoms is noticed.

Usual Adult Dose for Seborrheic Dermatitis:

0.77% topical gel: Apply to affected scalp areas twice a day (in the morning and evening) for 4 weeks.

1% topical shampoo: Wet hair and apply approximately 5 mL to the scalp. Up to 10 mL may be used for long hair. Lather and leave on hair and scalp for 3 minutes, then rinse off. Treatment should be repeated twice a week for 4 weeks, with at least 3 days between applications.

Usual Adult Dose for Cutaneous Candidiasis:

0.77% topical cream, suspension (lotion): Gently massage into affected and surrounding skin areas twice a day (in the morning and evening). Clinical improvement with relief of pruritus and other symptoms usually occurs within the first week of treatment.

Patients with tinea versicolor usually exhibit clinical and mycological clearing after 2 weeks of treatment.

Usual Adult Dose for Tinea Cruris:

0.77% topical cream, suspension (lotion): Gently massage into affected and surrounding skin areas twice a day (in the morning and evening). Clinical improvement with relief of pruritus and other symptoms usually occurs within the first week of treatment.

Patients with tinea versicolor usually exhibit clinical and mycological clearing after 2 weeks of treatment.

Usual Adult Dose for Tinea Versicolor:

0.77% topical cream, suspension (lotion): Gently massage into affected and surrounding skin areas twice a day (in the morning and evening). Clinical improvement with relief of pruritus and other symptoms usually occurs within the first week of treatment.

Patients with tinea versicolor usually exhibit clinical and mycological clearing after 2 weeks of treatment.

Usual Adult Dose for Tinea Corporis:

0.77% topical cream, suspension (lotion): Gently massage into affected and surrounding skin areas twice a day (in the morning and evening). Clinical improvement with relief of pruritus and other symptoms usually occurs within the first week of treatment.

0.77% topical gel: Gently massage gel into affected areas and surrounding skin twice a day (in the morning and evening) immediately after cleaning or washing areas to be treated. Interdigital tinea pedis and tinea corporis should be treated for 4 weeks.

Usual Adult Dose for Tinea Pedis:

0.77% topical cream, suspension (lotion): Gently massage into affected and surrounding skin areas twice a day (in the morning and evening). Clinical improvement with relief of pruritus and other symptoms usually occurs within the first week of treatment.

0.77% topical gel: Gently massage gel into affected areas and surrounding skin twice a day (in the morning and evening) immediately after cleaning or washing areas to be treated. Interdigital tinea pedis and tinea corporis should be treated for 4 weeks.

Usual Pediatric Dose for Onychomycosis -- Fingernail:

12 years or older:
8% topical solution: Apply once a day (preferably at bedtime or 8 hours before washing) to all affected nails with the applicator brush provided. Apply evenly over the entire nail plate and 5 mm of surrounding skin. If possible, the solution should be applied to the nail bed, hyponychium, and the under surface of the nail plate when it is free of the nail bed.

The product should not be removed on a daily basis. Daily applications should be made over the previous coat and removed with alcohol every 7 days. This cycle should be repeated throughout the duration of treatment.

Up to 48 weeks of daily applications and professional removal, as frequently as monthly, of the unattached, infected nail are considered the full treatment to achieve a clear or almost clear nail. Six months of therapy with professional removal of the unattached, infected nail may be required before initial improvement of symptoms is noticed.

Usual Pediatric Dose for Onychomycosis -- Toenail:

12 years or older:
8% topical solution: Apply once a day (preferably at bedtime or 8 hours before washing) to all affected nails with the applicator brush provided. Apply evenly over the entire nail plate and 5 mm of surrounding skin. If possible, the solution should be applied to the nail bed, hyponychium, and the under surface of the nail plate when it is free of the nail bed.

The product should not be removed on a daily basis. Daily applications should be made over the previous coat and removed with alcohol every 7 days. This cycle should be repeated throughout the duration of treatment.

Up to 48 weeks of daily applications and professional removal, as frequently as monthly, of the unattached, infected nail are considered the full treatment to achieve a clear or almost clear nail. Six months of therapy with professional removal of the unattached, infected nail may be required before initial improvement of symptoms is noticed.

Usual Pediatric Dose for Seborrheic Dermatitis:

16 years or older:
0.77% topical gel: Apply to affected scalp areas twice a day (in the morning and evening) for 4 weeks.

1% topical shampoo: Wet hair and apply approximately 5 mL to the scalp. Up to 10 mL may be used for long hair. Lather and leave on hair and scalp for 3 minutes, then rinse off. Treatment should be repeated twice a week for 4 weeks, with at least 3 days between applications.

Usual Pediatric Dose for Cutaneous Candidiasis:

10 years or older:
0.77% topical cream, suspension (lotion): Gently massage into affected and surrounding skin areas twice a day (in the morning and evening). Clinical improvement with relief of pruritus and other symptoms usually occurs within the first week of treatment.

Patients with tinea versicolor usually exhibit clinical and mycological clearing after 2 weeks of treatment.

Usual Pediatric Dose for Tinea Cruris:

10 years or older:
0.77% topical cream, suspension (lotion): Gently massage into affected and surrounding skin areas twice a day (in the morning and evening). Clinical improvement with relief of pruritus and other symptoms usually occurs within the first week of treatment.

Patients with tinea versicolor usually exhibit clinical and mycological clearing after 2 weeks of treatment.

Usual Pediatric Dose for Tinea Versicolor:

10 years or older:
0.77% topical cream, suspension (lotion): Gently massage into affected and surrounding skin areas twice a day (in the morning and evening). Clinical improvement with relief of pruritus and other symptoms usually occurs within the first week of treatment.

Patients with tinea versicolor usually exhibit clinical and mycological clearing after 2 weeks of treatment.

Usual Pediatric Dose for Tinea Corporis:

10 years or older:
0.77% topical cream, suspension (lotion): Gently massage into affected and surrounding skin areas twice a day (in the morning and evening). Clinical improvement with relief of pruritus and other symptoms usually occurs within the first week of treatment.

16 years or older:
0.77% topical gel: Gently massage gel into affected areas and surrounding skin twice a day (in the morning and evening) immediately after cleaning or washing areas to be treated. Interdigital tinea pedis and tinea corporis should be treated for 4 weeks.

Usual Pediatric Dose for Tinea Pedis:

10 years or older:
0.77% topical cream, suspension (lotion): Gently massage into affected and surrounding skin areas twice a day (in the morning and evening). Clinical improvement with relief of pruritus and other symptoms usually occurs within the first week of treatment.

16 years or older:
0.77% topical gel: Gently massage gel into affected areas and surrounding skin twice a day (in the morning and evening) immediately after cleaning or washing areas to be treated. Interdigital tinea pedis and tinea corporis should be treated for 4 weeks.

What other drugs will affect ciclopirox topical?

It is not likely that other drugs you take orally or inject will have an effect on topically applied ciclopirox. But many drugs can interact with each other. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about ciclopirox topical.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 5.01. Revision Date: 2012-09-11, 12:54:29 PM.

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