Econazole topical Pregnancy and Breastfeeding Warnings
Econazole topical Pregnancy Warnings
Econazole vaginal cream (not available in the US) has been used for the treatment of vaginal candidiasis in pregnant patients. In one study of 117 pregnant women with a duration of pregnancy ranging form 10 to 42 weeks, patients were treated with 150 mg once a day for three days. Three stillbirths were recorded. No congenital abnormalities were recorded among any of the infants. In another study, 112 pregnant women were treated with econazole 150 mg vaginal suppositories. No malformations were observed in 99 infants for whom information following delivery was available.
Econazole topical has been assigned to pregnancy category C by the FDA. Animal studies have revealed fetotoxic and embryotoxic effects at 10 to 80 times the human dose. Econazole has been used in clinical trials for the treatment of vaginal candidiasis, generally during the second and third trimester, without evidence of fetal harm. Econazole should only be used during pregnancy when need has been clearly established.
Econazole topical Breastfeeding Warnings
There are no data on the excretion of econazole into human milk. Oral econazole is excreted into rat milk. The manufacturer recommends that caution be used when administering econazole topical to nursing women.
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