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Dramamine II Side Effects

Generic Name: meclizine

Note: This page contains information about the side effects of meclizine. Some of the dosage forms included on this document may not apply to the brand name Dramamine II.

Not all side effects for Dramamine II may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to meclizine: oral capsule, oral tablet, oral tablet chewable

In addition to its needed effects, some unwanted effects may be caused by meclizine (the active ingredient contained in Dramamine II). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking meclizine:

Incidence not known
  • Cough
  • difficulty swallowing
  • dizziness
  • drowsiness
  • fast heartbeat
  • hives
  • itching
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shortness of breath
  • skin rash
  • tightness in the chest
  • unusual tiredness or weakness

Some of the side effects that can occur with meclizine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

  • Blurred vision
Incidence not known
  • Dry mouth
  • headache

For Healthcare Professionals

Applies to meclizine: compounding powder, oral tablet, oral tablet chewable

Nervous system

Nervous system (CNS) side effects have included headache, drowsiness and sedation. Motor skills may be impaired.[Ref]

With continued therapy, sedation due to meclizine diminishes.

An elderly woman suffered from memory loss, disorientation, paranoia, and agitation during treatment with meclizine over approximately 3 years. These symptoms returned on rechallenge.[Ref]


Gastrointestinal side effects have included nausea, vomiting, dry mouth, and constipation.[Ref]


Ocular side effects have included blurred vision, diplopia, and dry eyes.[Ref]


Genitourinary side effects have included urinary retention and dysuria.[Ref]


Anaphylactoid reactions have been reported.


Fatigue has been reported.


1. Cohen B, deJong JM "Meclizine and placebo in treating vertigo of vestibular origin." Arch Neurol 27 (1972): 129-35

2. "Product Information. Antivert (meclizine)." Roerig Division, New York, NY.

3. Molloy DW "Memory loss, confusion, and disorientation in an elderly woman taking meclizine." J Am Geriatr Soc 35 (1987): 454-6

4. Manning C, Scandale L, Manning EJ, Gengo FM "Central nervous system effects of meclizine and dimenhydrinate: evidence of acute tolerance to antihistamines." J Clin Pharmacol 32 (1992): 996-1002

5. Wood CD, Manno JE, Manno BR, Redetzki HM, Wood MJ, Mims ME "Evaluation of antimotion sickness drug side effects on performance." Aviat Space Environ Med 56 (1985): 310-6

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