Meclizine Pregnancy and Breastfeeding Warnings
Meclizine is also known as: Antivert, Antrizine, Bonine, D-Vert, Dramamine II, Dramamine Less Drowsy, Driminate II, Help I'm Nauseous, Meclicot, Medivert, Meni-D, Motion-Time, Ru-Vert-M, Sea-Calm, Travel-Ease, Verticalm
Meclizine Pregnancy Warnings
In a study 613 mothers given meclizine during the first trimester for the control of nausea and vomiting, no increase in the incidence of malformations was noted. In addition, other phenothiazine-type agents used for nausea including prochlorperazine and cyclizine were not associated with malformations. In another prospective observational study, 317 women were prescribed meclizine during the first-trimester of pregnancy. Nine infants were born with serious anomalies, including two defects of the central nervous system, two of the cardiovascular system, four of the digestive system, one of the musculoskeletal system, and one neoplasm. The risk of malformation did not differ significantly from patients with nausea and vomiting who received no antinauseant agents. The Collaborative Perinatal Project monitored 50,282 mother-child pairs, of which 1014 were exposed to meclizine during the first 16 weeks of pregnancy. The standardized relative risk was not elevated for meclizine use and malformations overall. For ocular malformations, the relative risk was 2.8, although there was no specific eye deformity noted. A review of prenatal drug use in 3,026 women with premature infants demonstrated an increased risk of retrolental fibroplasia with antihistamine use during the last two weeks of pregnancy. The dosage used or the particular antihistamine was not specified. The incidence of retrolental fibroplasia in premature infants exposed in utero to an antihistamine during this time was 21% compared to 11% in premature infants not exposed.
Meclizine has been assigned to pregnancy category B by the FDA. Although meclizine has been shown to be teratogenic in animals, studies of meclizine use in the first trimester of human pregnancy found no increase in the rate of malformations. Meclizine is only recommended for use during pregnancy when benefit outweighs risk.
Meclizine Breastfeeding Warnings
There are no data on the excretion of meclizine into breast milk.
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