Darbepoetin alfa Side Effects
Not all side effects for darbepoetin alfa may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to darbepoetin alfa: injection solution
Along with its needed effects, darbepoetin alfa may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking darbepoetin alfa:More common
- Abdominal or stomach pain
- accumulation of pus
- arm, back, or jaw pain
- blurred vision
- breathing problems (irregular, noisy, or trouble when resting)
- chest pain, discomfort, tightness, or heaviness
- cough producing mucus
- decrease in the amount of urine
- dilated neck veins
- dizziness, fainting, or lightheadedness
- dry mouth
- fast, slow, or irregular heartbeat
- fatigue or tiredness (extreme or unusual)
- pain, tenderness, swelling, or warmth over injection site
- pounding in the ears
- rapid breathing
- rapid or pounding pulse
- shortness of breath
- skin discoloration at the injection site
- sunken eyes
- swelling of the ankles, face, fingers, feet, hands, or lower legs
- trouble with breathing
- weight gain
- wrinkled skin
- difficulty with speaking (slow speech or unable to speak)
- double vision
- trouble with thinking
- trouble with walking
- unable to move the arms, legs, or face muscles (including numbness and tingling)
- Fever and sore throat
- pale skin
- skin rash
- unusual tiredness or weakness
Some side effects of darbepoetin alfa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- general feeling of discomfort or illness
- lack or loss of strength
- loss of appetite
- muscle aches, pains, or stiffness
- pain in the joints
- runny nose
- trouble with sleeping
For Healthcare Professionals
Applies to darbepoetin alfa: injectable solution
Cardiovascular side effects have included hypertension (up to 23%), hypotension (up to 22%), cardiac arrhythmias/cardiac arrest (up to 10%), angina pectoris/cardiac chest pain (8%), congestive heart failure (up to 6%), thrombosis vascular access (6%), acute myocardial infarction (2%), and transient ischemic attack (1%).
Hematologic side effects including an increased incidence of thrombotic events have been observed in patients treated with erythropoietic agents. In patients with cancer who received darbepoetin alfa, pulmonary emboli, thrombophlebitis, and thrombosis occurred more frequently than in placebo controls.
Gastrointestinal side effects have included diarrhea (up to 22%), constipation (up to 18%), vomiting (up to 15%), nausea (up to 14%), abdominal pain (up to 12%), and constipation (5%).
Musculoskeletal side effects have included myalgia (up to 21%), muscle spasm (17%), arthralgia (up to 13%), limb pain (up to 10%), and back pain (up to 8%).
Nervous system side effects have included headache (up to 16%), dizziness (up to 8%), stroke (up to 2%), and seizure (1%).
General side effects reported have included fatigue (33%), edema (up to 21%), fever (up to 19%), peripheral edema (up to 11%), access hemorrhage (7%), death (up to 7%), fluid overload (6%), access infection (6%), influenza-like symptoms (6%), asthenia (5%), and dehydration (5%).
In general, some of the adverse effects reported are typically associated with chronic renal failure, or recognized complications of dialysis, and may not necessarily be the result of darbepoetin alfa therapy.
Dermatologic side effects have included pruritus (up to 8%) and rash (7%).
Respiratory side effects have included upper respiratory infection (up to 27%), dyspnea (up to 12%), cough (up to 10%), and bronchitis (up to 6%).
Local adverse effects have included pain at injection site (up to 7%).
Immunologic side effects including neutralizing antibodies to erythropoietin, in association with pure red cell aplasia (PRCA) or severe anemia (with or without cytopenias) have been reported. Infection (24%) has been reported.
More about darbepoetin alfa
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- Darbepoetin alfa (polysorbate 80)
- Darbepoetin alfa
- Darbepoetin alfa Injection (Advanced Reading)
- Other brands: Aranesp
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