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Generic Name: epoetin alfa (e POE e tin AL fa)
Brand Names: Epogen, Procrit

What is Procrit?

Procrit (epoetin alfa) is a man-made form of a protein that helps your body produce red blood cells. This protein may be reduced when you have kidney failure or use certain medications. When fewer red blood cells are produced, you can develop a condition called anemia.

Procrit is used to treat anemia caused by chemotherapy or chronic kidney disease. Epoetin alfa is also used to reduce the need for red blood cell transfusions in people having certain types of surgery.

Procrit is available to cancer patients only under a special program called ESA APPRISE. You must be registered in the program and understand the risks and benefits of using this medicine.

Important information

Procrit can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. Epoetin alfa may also shorten remission time or survival time in some people with certain types of cancer. Talk with your doctor about the risks and benefits of using Procrit.

You should not use Procrit if you have uncontrolled high blood pressure, or if you have ever had pure red cell aplasia (PRCA, a type of anemia) caused by using epoetin alfa or darbepoetin alfa or (Aranesp).

Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain or heavy feeling, pain spreading to the arm or shoulder, shortness of breath, slurred speech, or problems with vision or balance.

Before using Procrit, tell your doctor if you have epilepsy or a history of seizures. Procrit may cause seizures. Be careful if you drive or do anything that requires you to be awake and alert.

To be sure Procrit is helping your condition, your blood may need to be tested often. Your blood pressure will also need to be checked. Visit your doctor regularly.

Before taking this medicine

You should not use Procrit if you are allergic to epoetin alfa or darbepoetin alfa or (Aranesp), or if:

  • you have untreated or uncontrolled high blood pressure;

  • you have had pure red cell aplasia (PRCA, a type of anemia) after using darbepoetin alfa or epoetin alfa; or

  • you use an Procrit multi-dose vial and you are pregnant or breast-feeding.

Do not use Procrit from a multi-dose vial when giving medicine to a baby. The multi-dose vial contains an ingredient that can cause serious side effects or death in very young infants or premature babies.

Procrit may shorten remission time in some people with head and neck cancer who are also being treated with radiation. Procrit may also shorten survival time in certain people with breast cancer, non-small cell lung cancer, head and neck cancer, cervical cancer, or lymphoid cancer. Talk with your doctor about your individual risk.

To make sure Procrit is safe for you, tell your doctor if you have;

  • heart disease, high blood pressure;

  • kidney disease (or if you are on dialysis);

  • a seizure disorder; or

  • a history of stroke, heart attack, or blood clots.

Using Procrit during pregnancy could harm the unborn baby. Tell your doctor if you are pregnant or if you become pregnant while using this medicine.

It is not known whether epoetin alfa passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Do not use Procrit from a multi-dose vial if you are pregnant or breast-feeding.

Procrit is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

How should I use Procrit?

Use Procrit exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Procrit is injected under the skin, or into a vein through an IV. You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.

Each single-use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose. Throw away any leftover medicine in a multi-dose vial 21 days after the first use.

You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your injections may be delayed based on the results of these tests.

You may need to take blood pressure medication while you are using Procrit. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

If you need surgery, tell the surgeon ahead of time that you are using Procrit. You may need to use a medicine to prevent blood clots.

Call your doctor if you feel weak, tired, light-headed, or short of breath, or if your skin looks pale. These may be signs that your body has stopped responding to Procrit.

Procrit is only part of a complete treatment program that may also include a special diet. Follow your doctor's instructions very closely.

Store in the refrigerator and protect from light. Do not freeze Procrit, and throw away the medication if it has become frozen.

Do not shake the medicine. Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of Procrit.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Procrit?

Procrit may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Procrit side effects

Get emergency medical help if you have signs of an allergic reaction to Procrit: hives, sweating; rapid pulse; wheezing, difficult breathing; severe dizziness or fainting; swelling of your face, lips, tongue, or throat.

Procrit can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use this medicine. Seek emergency medical help if you have:

  • heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;

  • signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;

  • signs of a blood clot in your leg - pain, swelling, warmth, or redness in one or both legs; or

  • dangerously high blood pressure - severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety, confusion, severe chest pain, shortness of breath, irregular heartbeats.

Call your doctor at once if you have:

  • unusual tiredness;

  • a seizure (convulsions);

  • low potassium - leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or

  • dangerously high blood pressure - severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety, confusion, severe chest pain, shortness of breath, irregular heartbeats.

Common Procrit side effects may include:

  • increased blood pressure;

  • joint pain, bone pain, muscle pain;

  • itching or rash;

  • fever, cough;

  • nausea, vomiting;

  • headache;

  • mouth pain; or

  • pain or redness where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Procrit?

Other drugs may interact with epoetin alfa, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your pharmacist can provide more information about Procrit.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Procrit only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 8.01. Revision Date: 2016-01-13, 10:15:11 AM.

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