Colesevelam Side Effects

Not all side effects for colesevelam may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to colesevelam: oral powder for suspension, oral tablet

Along with its needed effects, colesevelam may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking colesevelam:

Less common
  • Anxiety
  • blurred vision
  • chills
  • cold sweats
  • coma
  • confusion
  • congestion
  • cool, pale skin
  • cough
  • depression
  • diarrhea
  • dizziness
  • dry or sore throat
  • fast heartbeat
  • fever
  • general feeling of discomfort or illness
  • headache
  • hoarseness
  • increased hunger
  • joint pain
  • loss of appetite
  • muscle aches or pain
  • nausea
  • nervousness
  • nightmares
  • pounding in the ears
  • runny nose
  • seizures
  • shakiness
  • shivering
  • slow or fast heartbeat
  • slurred speech
  • sweating
  • tender, swollen glands in the neck
  • trouble with sleeping
  • trouble with swallowing
  • unusual tiredness or weakness
  • voice changes
  • vomiting
Incidence not known
  • Bleeding after defecation
  • darkened urine
  • difficulty with swallowing
  • indigestion
  • pain or discomfort in the chest
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pressure in the stomach
  • severe stomach pain
  • swelling of the abdominal or stomach area
  • unable to swallow saliva
  • uncomfortable swelling around the anus
  • yellow eyes or skin

Some side effects of colesevelam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Acid or sour stomach
  • belching
  • bloating
  • constipation
  • full or bloated feeling
  • heartburn
  • pain or cramping in the abdomen or stomach
  • stomach discomfort, upset, or pain
Less common
  • Lack or loss of strength
  • sneezing
  • stuffy nose

For Healthcare Professionals

Applies to colesevelam: oral powder for reconstitution, oral tablet

Cardiovascular

Cardiovascular side effects including hypertension, myocardial infarction, aortic stenosis, and bradycardia have been reported in 3% of patients.

Gastrointestinal

Gastrointestinal side effects have included flatulence (12%), constipation (8.7% to 11%), dyspepsia (3.9% to 8%), diarrhea (5%), and nausea (3% to 4%). Bowel obstruction (in patients with a history of bowel obstruction or resection), dysphagia or esophageal obstruction (occasionally requiring medical intervention), fecal impaction, pancreatitis, abdominal distension, exacerbation of hemorrhoids, and increased transaminases have been reported in postmarketing experience.

Immunologic

Immunologic side effects have included infection (10%).

General

In the lipid-lowering trials, 807 patients received at least one dose of colesevelam therapy (total exposure 199 patient-years). In the type 2 diabetes trials, 566 patients received at least one dose of colesevelam therapy (total exposure 209 patient years). In clinical trials for the reduction of LDL-C, 68% of patients receiving colesevelam therapy versus 64% of patients receiving placebo reported an adverse event. In clinical trials of type 2 diabetes, 60% of patients receiving colesevelam therapy versus 56% of patients receiving placebo reported an adverse event.

Respiratory

Respiratory side effects have included nasopharyngitis (4%), pharyngitis (3%), rhinitis (3%), sinusitis (2%), and increased cough (2%).

Musculoskeletal

Musculoskeletal side effects have included myalgia (2%).

Metabolic

Metabolic side effects have included hypoglycemia (3%). Hypertriglyceridemia has been reported in postmarketing experience.

Nervous system

Nervous system side effects have included headache (6%), pain (6%), and back pain (3%).

Other

Other side effects have included abdominal pain (5%), accidental injury (4%), asthenia (4%), and flu syndrome (3%).

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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