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Oruvail

Generic Name: Ketoprofen
Class: Other Nonsteroidal Anti-inflammatory Agents
Chemical Name: 3-Benzoyl-α-methylbenzeneacetic acid
Molecular Formula: C16H14O3
CAS Number: 22071-15-4

Warning(s)

  • Cardiovascular Risk
  • Possible increased risk of serious (sometimes fatal) cardiovascular thrombotic events (e.g., MI, stroke).1 Risk may increase with duration of use.1 Individuals with cardiovascular disease or risk factors for cardiovascular disease may be at increased risk.1 (See Cardiovascular Effects under Cautions.)

  • Contraindicated for the treatment of pain in the setting of CABG surgery.1

  • GI Risk
  • Increased risk of serious (sometimes fatal) GI events (e.g., bleeding, ulceration, perforation of the stomach or intestine).1 Serious GI events can occur at any time and may not be preceded by warning signs and symptoms.1 Geriatric individuals are at greater risk for serious GI events.1 (See GI Effects under Cautions.)

Introduction

Prototypical NSAIA; propionic acid derivative.1 2 3 4 30 53 93 205

Uses for Oruvail

Consider potential benefits and risks of ketoprofen therapy as well as alternative therapies before initiating therapy with the drug.1 Use lowest possible effective dosage and shortest duration of therapy consistent with patient’s treatment goals.1

Inflammatory Diseases

Symptomatic treatment of osteoarthritis and rheumatoid arthritis.1 36 96 97 98 99 100 101 102 103 104 105 106 107 108 131 132 134 135 136 137 138 139 147 148 150 153 154 158 205

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Has been used in the symptomatic treatment of ankylosing spondylitis.97 104 105 106 108 109 138 142 143 144 146 175 205

Pain

Relief of pain.1 121 160 166 171 173 174 235 236 238 239

Dysmenorrhea

Symptomatic management of primary dysmenorrhea.1 50 161 164 234

Oruvail Dosage and Administration

General

  • Consider potential benefits and risks of ketoprofen therapy as well as alternative therapies before initiating therapy with the drug.1

Administration

Oral Administration

Administer orally once daily as extended-release capsules or 3 or 4 times daily as conventional capsules.1

Administration with antacids,1 97 102 115 116 142 149 food,1 104 or milk1 may minimize adverse GI effects.

Ketoprofen extended-release capsules are not recommended for the management of acute pain because of slow onset of action.1

Dosage

To minimize the potential risk of adverse cardiovascular and/or GI events, use lowest effective dosage and shortest duration of therapy consistent with the patient’s treatment goals.1 Adjust dosage based on individual requirements and response; attempt to titrate to the lowest effective dosage.1

Adults

Inflammatory Diseases
Osteoarthritis or Rheumatoid Arthritis
Oral

Conventional capsules: Initially, 75 mg 3 times daily or 50 mg 4 times daily.1 Base subsequent dosage on clinical response and tolerance.1

Extended-release capsules: Initially, 200 mg once daily.1 Base subsequent dosage on clinical response and tolerance.1

Pain
Oral

Conventional capsules: Usual dosage is 25–50 mg every 6–8 hours as needed.1

Dysmenorrhea
Oral

Conventional capsules: Usual dosage is 25–50 mg every 6–8 hours as needed.1

Prescribing Limits

Adults

Inflammatory Diseases
Osteoarthritis or Rheumatoid Arthritis
Oral

Conventional capsules: Maximum 300 mg daily.1

Extended-release capsules: Maximum 200 mg daily.1

Pain or Dysmenorrhea
Oral

Conventional capsules: Maximum 300 mg daily.1

Special Populations

Hepatic Impairment

Maximum recommended initial total dosage is 100 mg daily in patients with hepatic impairment and serum albumin concentrations <3.5 g/dL.1

Renal Impairment

Mild renal impairment: Maximum recommended dosage is 150 mg daily.1

Severe renal impairment (GFR <25 mL/minute per 1.73 m2 or end-stage renal impairment): Maximum recommended dosage is 100 mg daily.1 (See Renal Impairment under Cautions.)

Geriatric Patients

Consider reduced initial dosage in patients >75 years of age.1

Cautions for Oruvail

Contraindications

  • Known hypersensitivity to ketoprofen or any ingredient in the formulation.1

  • History of asthma, urticaria, or other sensitivity reactions precipitated by aspirin or other NSAIAs.1 26 48 83 86 89 90 91 92 177

  • Treatment of perioperative pain in the setting of CABG surgery.1

Warnings/Precautions

Warnings

Cardiovascular Effects

Selective COX-2 inhibitors have been associated with increased risk of cardiovascular events (e.g., MI, stroke) in certain situations.284 Several prototypical NSAIAs also have been associated with increased risk of cardiovascular events.288 289 290 Information not available on risk associated with ketoprofen at this time.288 289 290

Use NSAIAs with caution and careful monitoring (e.g., monitor for development of cardiovascular events), and at the lowest effective dosage for the shortest duration necessary. 1

Short-term use to relieve acute pain, especially at low dosages, does not appear to be associated with increased risk of serious cardiovascular events (except immediately following CABG surgery).284

No consistent evidence that concomitant use of low-dose aspirin mitigates the increased risk of serious adverse cardiovascular events associated with NSAIAs.1 (See Specific Drugs under Interactions.)

Hypertension and worsening of preexisting hypertension reported; either event may contribute to the increased incidence of cardiovascular events.1 Use with caution in patients with hypertension; monitor BP.1 Impaired response to certain diuretics may occur.1 (See Specific Drugs under Interactions.)

Fluid retention and edema reported.1 Caution in patients with fluid retention or heart failure.1

GI Effects

Serious GI toxicity (e.g., bleeding, ulceration, perforation) can occur with or without warning symptoms;1 241 242 245 increased risk in those with a history of GI bleeding or ulceration, geriatric patients, smokers, those with alcohol dependence, and those in poor general health.1 233 270 281

For patients at high risk for complications from NSAIA-induced GI ulceration (e.g., bleeding, perforation), consider concomitant use of misoprostol;244 270 273 274 alternatively, consider concomitant use of a proton-pump inhibitor (e.g., omeprazole)244 270 273 or use of an NSAIA that is a selective inhibitor of COX-2 (e.g., celecoxib).273

Renal Effects

Direct renal injury, including renal papillary necrosis, reported in patients receiving long-term NSAIA therapy.1

Potential for overt renal decompensation.1 9 15 26 48 83 177 198 Increased risk of renal toxicity in patients with renal1 15 48 83 177 198 or hepatic1 15 26 48 83 177 198 impairment or heart failure,1 26 48 83 177 198 in geriatric patients,1 48 177 in patients with volume depletion,1 16 26 48 83 177 198 224 and in those receiving a diuretic,1 ACE inhibitor,1 or angiotensin II receptor antagonist.286 (See Renal Impairment under Cautions.)

Sensitivity Reactions

Hypersensitivity Reactions

Anaphylactoid reactions reported.1

Immediate medical intervention and discontinuance for anaphylaxis.1

Avoid in patients with aspirin triad (aspirin sensitivity, asthma, nasal polyps); caution in patients with asthma.1

Dermatologic Reactions

Serious skin reactions (e.g., exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) reported;1 142 can occur without warning.1 Discontinue at first appearance of rash or any other signs of hypersensitivity (e.g., blisters, fever, pruritus).1

General Precautions

Hepatic Effects

Severe reactions including jaundice, fatal fulminant hepatitis, liver necrosis, and hepatic failure (sometimes fatal) reported rarely with NSAIAs.1

Elevations of serum ALT or AST reported.1

Monitor for symptoms and/or signs suggesting liver dysfunction; monitor abnormal liver function test results.1 Discontinue if signs or symptoms of liver disease or systemic manifestations (e.g., eosinophilia, rash) occur or if liver function test abnormalities persist or worsen.1 209 210

Hematologic Effects

Anemia reported rarely.1 141 Determine hemoglobin concentration or hematocrit in patients receiving long-term therapy if signs or symptoms of anemia occur.1 209 210

May inhibit platelet aggregation and prolong bleeding time.1 34 40 41 47 54

Other Precautions

Not a substitute for corticosteroid therapy; not effective in the management of adrenal insufficiency.1

May mask certain signs of infection.1 83 177 209 210

Obtain CBC and chemistry profile periodically during long-term use.1

Specific Populations

Pregnancy

Category C.1 Avoid use in third trimester because of possible premature closure of the ductus arteriosus.1

Lactation

Not known whether distributed into milk in humans.1 Use not recommended.1

Pediatric Use

Safety and efficacy not established in children <18 years of age.1

Geriatric Use

Caution advised.1 Geriatric adults appear to tolerate NSAIA-induced adverse effects less well than younger individuals.1 Fatal adverse GI effects reported more frequently in geriatric patients than younger adults.1

Select dosage with caution because of age-related decreases in renal function.1 Dosage adjustment recommended in geriatric patients >75 years of age.1 May be useful to monitor renal function.1

Hepatic Impairment

Monitor closely.1 Reduced dosage may be necessary; use lowest effective dosage.1 (See Hepatic Impairment under Dosage and Administration.)

Renal Impairment

Use not recommended in patients with advanced renal disease; close monitoring of renal function advised if used.1

Reduced maximum dosage recommended.1 (See Renal Impairment under Dosage and Administration.)

Common Adverse Effects

Dyspepsia,1 99 100 102 104 105 109 114 118 123 134 136 139 234 nausea,1 96 99 104 106 109 115 123 125 129 132 135 136 137 138 139 140 234 abdominal pain,1 104 115 127 135 136 137 138 140 234 diarrhea,1 102 104 105 107 114 127 132 133 234 constipation,1 99 104 105 107 109 118 132 135 143 flatulence,1 96 109 137 147 149 155 anorexia,1 107 109 135 137 147 vomiting,1 104 105 109 125 135 136 137 139 stomatitis,1 105 132 146 149 headache,1 99 102 104 105 106 109 118 123 127 129 234 dizziness,1 104 106 109 118 127 131 132 138 234 CNS depression,106 109 138 147 155 158 173 190 CNS excitation,1 104 105 132 150 155 161 tinnitus,1 118 119 164 visual disturbances,1 rash,1 96 104 105 127 132 135 155 190 renal impairment.1 105 118 125 135 158 187 205 224

Interactions for Oruvail

Protein-bound Drugs

Potential for ketoprofen to be displaced from binding sites by, or to displace from binding sites, other protein-bound drugs.52 78 Observe for adverse effects.209 210 211

Specific Drugs

Drug

Interaction

Comments

ACE inhibitors

Reduced BP response to the ACE inhibitor1

Monitor BP1

Angiotensin II receptor antagonists

Reduced BP response to the angiotensin II receptor antagonist291

Monitor BP291

Antacids (magnesium- or aluminum-containing)

Conventional capsules: Pharmacokinetic interaction unlikely1

Anticoagulants (warfarin)

Possible bleeding complications1

Increased PT reported 240

Caution advised 1

Aspirin

Decreased ketoprofen protein binding1 52

Increased risk of GI ulceration or other complications 1

No consistent evidence that low-dose aspirin mitigates the increased risk of serious cardiovascular events associated with NSAIAs284

Concomitant use not recommended1

Clinical importance of pharmacokinetic changes unknown1

Digoxin

Pharmacokinetic interaction unlikely1

Diuretics (furosemide, thiazides)

Reduced natriuretic effects1

Monitor for diuretic efficacy and renal failure1

Lithium

Increased plasma lithium concentrations1 209 229

Monitor for lithium toxicity1 209 229

Methotrexate

Possible increased and prolonged blood concentrations of methotrexate1 24 210 216 217 218 219 221 231

Use with caution1

Probenecid

Decreased clearance of ketoprofen and/or its conjugates78

Concomitant use not recommended1

Salicylates

Possible altered elimination of ketoprofen; no change in the pharmacokinetics of salicylate52

Clinical importance unknown52

Thrombolytic agents (streptokinase)

Possible bleeding complications39

Use with caution39

Oruvail Pharmacokinetics

Absorption

Bioavailability

Well absorbed following oral administration; bioavailability is about 90%.1 Peak plasma concentration usually attained within 0.5–2 hours (conventional capsules) or 6–7 hours (extended-release capsules).1 58 60 61 62 64 66 69 71

Food

Food delays time to peak plasma concentration by <1 hour or about 2 hours following administration as conventional capsules or extended-release capsules, respectively.1

Distribution

Extent

Distributed into synovial fluid57 64 67 68 71 227 and the CNS.75

Not known whether ketoprofen is distributed into human milk.1

Plasma Protein Binding

>99% (mainly albumin).1 75

Elimination

Metabolism

Rapidly and extensively metabolized in the liver; active metabolites not identified.1 2 45 59

Elimination Route

Excreted principally in urine.1 57 59 60 61 62 70 72 80 228

Half-life

Conventional capsules: 2–4 hours.1

Extended-release capsules: 5.4 hours.1

Special Populations

Renal Impairment: Half-life (when given as conventional capsules) prolonged to about 3 hours in patients with mild renal impairment and to about 5–9 hours in patients with moderate to severe renal impairment.1

Stability

Storage

Oral

Conventional and Extended-release Capsules

Tight1 , light resistant containers2 at 25°C1 2 ; protect from direct light and excessive heat and humidity.1

Actions

  • Inhibits cyclooxygenase-1 (COX-1) and COX-2.264 265 266 267 268 269 270

  • Pharmacologic actions similar to those of other prototypical NSAIAs; exhibits anti-inflammatory, analgesic, and antipyretic activity.1 31 34 42 43 205

Advice to Patients

  • Importance of reading the medication guide for NSAIAs that is provided each time the drug is dispensed.1

  • Risk of serious cardiovascular events with long-term use.1

  • Risk of GI bleeding and ulceration.1 247 255

  • Risk of serious skin reactions.1 Risk of anaphylactoid and other sensitivity reactions.1

  • Risk of hepatotoxicity.1

  • Importance of notifying clinician if signs and symptoms of a cardiovascular event (chest pain, dyspnea, weakness, slurred speech) occur.1

  • Importance of notifying clinician if signs and symptoms of GI ulceration or bleeding, unexplained weight gain, or edema develops.1

  • Importance of discontinuing ketoprofen and contacting clinician if rash or other signs of hypersensitivity (blisters, fever, pruritus) develop.1 Importance of seeking immediate medical attention if an anaphylactic reaction occurs.1

  • Importance of discontinuing therapy and contacting clinician immediately if signs and symptoms of hepatotoxicity (nausea, fatigue, lethargy, pruritus, jaundice, upper right quadrant tenderness, flu-like symptoms) occur.1

  • Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.1 Importance of avoiding ketoprofen in late pregnancy (third trimester).1

  • Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant diseases.1

  • Importance of informing patients of other important precautionary information.1 (See Cautions.)

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Ketoprofen

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Oral

Capsules

50 mg*

Ketoprofen Capsules

Mylan, Teva

75 mg*

Ketoprofen Capsules

Mylan, Teva

Capsules, extended-release

200 mg*

Ketoprofen Capsules extended-release

Mylan

Oruvail

Wyeth

Comparative Pricing

This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 02/2014. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.

Ketoprofen 50MG Capsules (TEVA PHARMACEUTICALS USA): 90/$20.98 or 180/$31.98

Ketoprofen 75MG Capsules (TEVA PHARMACEUTICALS USA): 60/$16.99 or 180/$34.98

Ketoprofen CR 200MG 24-hr Capsules (MYLAN): 30/$134.99 or 90/$404.98

AHFS DI Essentials. © Copyright, 2004-2014, Selected Revisions March 1, 2008. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.

† Use is not currently included in the labeling approved by the US Food and Drug Administration.

References

1. Wyeth. Orudis and Oruvail (ketoprofen) capsules and extended-release capsules prescribing information. Philadelphia, PA; 2006 Mar.

2. Wyeth Laboratories Inc. Product information form for American Hospital Formulary Service on Orudis. Philadelphia, PA; 1985.

3. Windholz M, ed. The Merck index. 10th ed. Rahway, NJ: Merck & Co, Inc; 1983:573,712,762,920,1294.

4. Reynolds JEF, ed. Martindale: the extra pharmacopoeia. 28th ed. London: The Pharmaceutical Press; 1982:261-2.

5. Moncada S, Roderick JF, Vane JR. Prostaglandins, prostacyclin, thromboxane A2, and leukotrienes. In: Gilman AG, Goodman L, Rall TW et al, eds. Goodman and Gilman’s the pharmacological basis of therapeutics. 7th ed. New York: Macmillan Publishing Company; 1985:660-73.

6. Atkinson DC, Collier HOJ. Salicylates: molecular mechanism of therapeutic action. Adv Pharmacol Chemother. 1980; 17:233-88. [PubMed 7004141]

7. Hart FD. Rheumatic disorders. In: Avery GS, ed. Drug treatment: principles and practice of clinical pharmacology and therapeutics. 2nd ed. Sydney: ADIS Press; 1980:846-88.

8. Brater DC. Drug-drug and drug-disease interactions with nonsteroidal anti-inflammatory drugs. Am J Med. 1986; 80(Suppl 1A):62-77. [IDIS 212035] [PubMed 3511686]

9. Wolf RE. Nonsteroidal anti-inflammatory drugs. Arch Intern Med. 1984; 144:1658-60. [IDIS 188705] [PubMed 6235791]

10. Court H, Volans GN. Poisoning after overdose with non-steroidal anti-inflammatory drugs. Adv Drug React Ac Pois Rev. 1984; 3:1-21.

11. Abramson S, Edelson H, Kaplan H et al. Inhibition of neutrophil activation by nonsteroidal anti-inflammatory drugs. Am J Med. 1984; 10:3-6.

12. McElnay JC, D’Arcy PF. Displacement of albumin-bound warfarin by anti-inflammatory agents in vitro. J Pharm Pharmacol. 1980; 32:709-11. [IDIS 126210] [PubMed 6107346]

13. Pawlotsky Y, Louboutin JY, Chales G et al. Interactions ketoprofene-aspirine. (French; with English abstract.) Sem Hop Paris. 1983; 59:3218-20.

14. Lewis GR, Jacobs SG, Vavra I. Effect of ketoprofen on serum digoxin concentrations. Curr Ther Res. 1985; 38:494-9.

15. Robinson DR. Prostaglandins and the mechanism of action of anti-inflammatory drugs. Am J Med. 1983; 10:26-31.

16. O’Brien WM. Pharmacology of nonsteroidal anti-inflammatory drugs: practical review for clinicians. Am. J Med. 1983; 10:32-9.

17. Harris ED Jr. Evaluation of pathophysiology and drug effects on rheumatoid arthritis. Am J Med. 1983; 10:56-61.

18. Hart FD, Huskisson EC. Non-steroidal anti-inflammatory drugs: current status and rational therapeutic use. Drugs. 1984; 27:232-55. [IDIS 182488] [PubMed 6368185]

19. Simon LS, Mills JA. Nonsteroidal antiinflammatory drugs. N Engl J Med. 1980; 302:1179-85. [IDIS 113555] [PubMed 6988717]

20. Ferreira SH, Lorenzetti BB, Correa FMA. Central and peripheral analgesic action of aspirin-like drugs. Eur J Pharmacol. 1978; 53:39-48. [PubMed 310771]

21. Bernheim HA, Block LH, Atkins E. Fever: pathogenesis, pathophysiology, and purpose. Ann Intern Med. 1979; 91:261-70. [PubMed 223485]

22. Wilkens RF. The use of nonsteroidal anti-inflammatory agents. JAMA. 1978; 240:1632-5. [IDIS 87147] [PubMed 691156]

23. Capetola RJ, Rosenthale ME, Dubinsky B et al. Peripheral antialgesics: a review. J Clin Pharmacol. 1983; 23:545-56. [IDIS 180501] [PubMed 6363465]

24. Thyss A, Milano G, Kubar J et al. Clinical and pharmacokinetic evidence of a life-threatening interaction between methotrexate and ketoprofen. Lancet. 1986; 1:256-8. [IDIS 210465] [PubMed 2868265]

25. Ylikorkala O, Dawood YM. New concepts in dysmenorrhea. Am J Obstet Gynecol. 1978; 130:833-47. [PubMed 25021]

26. McNeil Pharmaceutical. Tolectin DS and Tolectin prescribing information. Spring House, PA; 1985 Aug.

27. Flower RJ, Moncada S, Vane JR. Analgesic-antipyretics and anti-inflammatory agents; drugs employed in the treatment of gout. In: Gilman AG, Goodman L, Rall TW et al, eds. Goodman and Gilman’s the pharmacological basis of therapeutics. 7th ed. New York: Macmillan Publishing Co; 1985:674-715.

28. Moncada S, Vane JR. Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls. N Engl J Med. 1979; 300:1142-7. [PubMed 219340]

29. Standing Advisory Committee for Haematology of the Royal College of Pathologists. Drug interaction with coumarin derivative anticoagulants. BMJ. 1982; 285:274-5. [IDIS 154878] [PubMed 6807448]

30. Brogden RN, Speight TM, Avery GS. Ketoprofen: a preliminary report of its pharmacological activity and therapeutic efficacy in rheumatic disorders. Drugs. 1974; 8:168-75. [IDIS 47978] [PubMed 4611741]

31. Julou L, Guyonnet JC, Ducrot R et al. Ketoprofen (19.583 R.P.) (2-(3-benzoylphenyl)-propionic acid): main pharmacological properties—outline of toxicological and pharmacokinetic data. Scand J Rheumatol. 1976; 14(Suppl):33-44.

32. Anon. Naproxen (Naprosyn) and ketoprofen (Orudis). Drug Ther Bull. 1974; 12:25-7. [PubMed 4616814]

33. Julou L, Guyonnet JC, Ducrot R et al. Some pharmacological and toxicological studies on ketoprofen. Rheumatol Rehabil. 1976; 15(Suppl):5-10.

34. Fossgreen J. Ketoprofen: a survey of current publications. Scand J Rheumatol. 1976; 14(Suppl):7-32.

35. Simon LS, Mills JA. Nonsteroidal antiinflammatory drugs. N Engl J Med. 1980; 302:1237-43. [IDIS 113536] [PubMed 6988723]

36. Renier JC, Boasson M. Etude de l’acide (benzoyl-3 phenyl)-2 propionique en rhumatologie (a propos de 27 observations). Arch Med Ouest. 1973; 5:485-92.

37. Liversidge GG. Ketoprofen. In: Florey K, ed. Analytical profiles of drug substances. Vol 10. New York: Academic Press; 1981:443-71.

38. Hamor GH. Nonsteroidal anti-inflammatory agents. In: Foye WO, ed. Principles of medical chemistry. 2nd ed. Philadelphia, PA: Lea & Febiger; 1981:561-80.

39. Hoechst-Roussel. Streptase prescribing information. Sommerville, NJ: 1982 Apr.

40. Gandini R, Cunietti E, Pappalepore V et al. Effects of intravenous high doses of ketoprofen on blood clotting, bleeding time and platelet aggregation in man. J Int Med Res. 1983; 11:243-6. [PubMed 6617983]

41. Marmo E, Ottavo R, Giordano L et al. Analisi sperimentale di alcuni aspetti farmacodinamici del ketoprofene lisina. (Italian; with English summary.) Arch Sci Med. 1980; 137:387-404.

42. Kubota T, Komatsu H, Kawamoto H et al. Studies on the effects of anti-inflammatory action of benzoyl-hydrotropic acid (ketoprofen) and other drugs, with special reference to prostaglandin synthesis. Arch Int Pharmacodyn Ther. 1979; 237:169-76. [PubMed 485681]

43. Guyonnet JC, Julou L. Relationship between the inhibitory activity on “RCS” and prostaglandins synthesis and the anti-inflammatory activity of ketoprofen and several other non-steroidal anti-inflammatory agents. Rheumatol Rehabil. 1976; 15(Suppl):11-4.

44. Migne J, Vedrine Y, Bourat G et al. Action of ketoprofen on hepatic lysosome in the rat. Rheumatol Rehabil. 1976; 15(Suppl):15-9.

45. Gosselin RE, Smith RP, Hodge HC et al. Clinical toxicology of commercial products. 5th ed. Baltimore: The Williams & Wilkins Co; 1984:I-10.

46. Fiore CE, Petralito A, Mazzarino MC et al. Effects of ketoprofen on the calciuric and uricosuric activities of calcitonin in man. J Endocrinol Invest. 1981; 4:81-4. [PubMed 7240673]

47. Migne J, Santonja R, Kunz S. Etude comparee de l’activite antiagregante plaquettaire de plusieurs anti-inflammatoires. (French; with English summary.) Sem Hop Paris. 1983; 59:3197-203.

48. The Upjohn Company. Motrin prescribing information. Kalamazoo, MI; 1985 Jul.

49. Deraedt R, Jouquey S, Benzoni J et al. Inhibition of prostaglandin biosynthesis by non-narcotic analgesic drugs. Arch Int Pharmacodyn Ther. 1976; 224:30-42. [PubMed 13749]

50. Dawood MY. Dysmenorrhoea and prostaglandins: pharmacological and therapeutic considerations. Drugs. 1981; 22:42-56. [IDIS 164822] [PubMed 6790261]

51. O’Reilly RA. Anticoagulant, antithrombotic, and thrombolytic drugs. In: Gilman AG, Goodman LS, Rall TW et al, eds. Goodman and Gilman’s the pharmacologic basis of therapeutics. 7th ed. New York: Macmillan Publishing Company; 1985:1338-59.

52. Williams RL, Upton RA, Buskin JN et al. Ketoprofen-aspirin interactions. Clin Pharmacol Ther. 1981; 30:226-31. [IDIS 136587] [PubMed 7249506]

53. Julou L, Guyonnet JC, Ducrot R et al. Etude des proprietes pharmacologiques d’un nouvel anti-inflammatoire, l’acide (benzoyl-3 phenyl)-2 propionique (19583 R.P.). J Pharmacol (Paris). 1971; 2:259-86.

54. Migne J, Santonja R, Kunz S. Etude comparee de l’activité anti-agregante plaquettaire de plusieurs anti-inflammatoires. Therapie. 1973; 28:861-76. [PubMed 4368089]

55. Populaire P, Terlain B, Pascal S et al. Comportement biologique: taux sériques, excrétion et biotransformation de l’acide (benzoyl-3 phényl)-2 propionique ou ketoprofene chez l’animal et chez l’homme. (French; with English abstract.) Ann Pharm Fr. 1973; 31:735-49.

56. Blanchard JC, Schneider YJ, Tulkens P et al. Cellular uptake and subcellular distribution of two non-steroidal anti-inflammatory drugs: indomethacin and ketoprofen. Arch Int Pharmacodyn Ther. 1979; 240:4-16. [PubMed 507996]

57. Grahame R, Billings R, Reeback J et al. Blood level studies on ketoprofen. Rheumatol Rehabil. 1978; 17(Suppl):64-70.

58. Sala G, Silvestri N, Castegnaro E et al. Pharmacokinetic and therapeutic effects of ketoprofen. Farmaco. 1978; 33:455-60.

59. Delbarre F, Roucayrol JC, Amor B et al. Pharmacokinetic study of ketoprofen (19.583 R.P.) in man using the tritiated compound. Scand J Rheumatol. 1976; 5(Suppl 14):45-52.

60. Lewellen ORW, Templeton R. The pharmacokinetics of ketoprofen in man during and after repeated oral dosing (50 mg q.i.d.) with Orudis. Scand J Rheumatol. 1976; 5(Suppl 14):53-62. [PubMed 1257710]

61. Upton RA, Williams RL, Guentert TW et al. Ketoprofen pharmacokinetics and bioavailability based on an improved sensitive and specific assay. Eur J Clin Pharmacol. 1981; 20:127-33. [IDIS 136218] [PubMed 7262174]

62. Ishizaki T, Sasaki T, Suganuma T et al. Pharmacokinetics of ketoprofen following single oral, intramuscular and rectal doses and after repeated oral administration. Eur J Clin Pharmacol. 1980; 18:407-14. [IDIS 125552] [PubMed 7439263]

63. Brazier JL, Tamisier JN, Ambert D et al. Bioavailability of ketoprofen in man with and without concomitant administration of aluminium phosphate. Eur J Clin Pharmacol. 1981; 19:305-7. [IDIS 134348] [PubMed 7286034]

64. Mitchell WS, Scott P, Kennedy AC et al. Clinico-pharmacological studies on ketoprofen (″Orudis’). Curr Med Res Opin. 1975; 3:423-30.

65. Upton RA, Buskin JN, Guentert TW et al. Ketoprofen kinetics based on a new high-pressure liquid chromatographic assay. Clin Pharmacol Ther. 1979; 25:251-2.

66. Tamisier JN, Brazier JL, Ambert D et al. Etude de la biodisponibilite du ketoprofene (Profenid) administre par voie orale en association avec un protecteur gastrique (phosphate d’alumine, Phosphalugel). (French; with English abstract.) Sem Hop Paris. 1983; 59:3214-7.

67. Kohler G, Mohing W, Lutz D et al. Teneur en principe actif du sang, du liquide synovial, de la membrane synoviale et des tissus osseux, musculaires et adipeux avoisinants chez des malades atteints de polyarthrite rhumatoide et ayant recu une injection intramusculaire unique de ketoprofene ou d’acide acetylsalicylique (trois heures apres injection). (French; with English abstract.) Sem Hop Paris. 1983; 59:3210-3.

68. Kennedy AC. Pharmacocinetique du ketoprofene dans le liquide synovial. (French; with English abstract.) Sem Hop Paris. 1983; 59:3208-9.

69. Advenier C, Roux A, Gobert C et al. Pharmacokinetics of ketoprofen in the elderly. Br J Clin Pharmacol. 1983; 16:65-70. [IDIS 173165] [PubMed 6882624]

70. Upton RA, Buskin JN, Williams RL et al. Negligible excretion of unchanged ketoprofen, naproxen, and probenecid in urine. J Pharm Sci. 1980; 69:1254-7. [IDIS 124694] [PubMed 7452451]

71. Kennedy AC. Synovial-fluid pharmacokinetics of ketoprofen. Rheumatol Rehabil. 1976; 15(Suppl):20-1.

72. Stafanger G, Larsen HW, Hansen H et al. Pharmacokinetics of ketoprofen in patients with chronic renal failure. Scand J Rheumatol. 1981; 10:189-92. [PubMed 7291952]

73. Houghton GW, Dennis MJ, Rigler ED et al. Urinary pharmacokinetics of orally administered ketoprofen in man. Eur J Drug Metab Pharmacokinet. 1984; 9:201-4. [PubMed 6519121]

74. Verbeeck RK, Wallace SM, Loewen GR. Reduced elimination of ketoprofen in the elderly is not necessarily due to impaired glucuronidation. Br J Clin Pharmacol. 1984; 17:783-4. [PubMed 6743473]

75. Netter P, Lapicque F, Bannwarth B et al. Diffusion of intramuscular ketoprofen into the cerebrospinal fluid. Eur J Clin Pharmacol. 1985; 29:319-21. [IDIS 208244] [PubMed 4076328]

76. Queneau P, Decousus H, Ollagnier M et al. Chronocinetique du ketoprofene administre per os et en perfusion veineuse continue. (French; with English summary.) Rev Rhum. 1985; 52:403-8.

77. Houghton GW, Dennis MJ, Rigler ED et al. Comparative pharmacokinetics of ketoprofen derived from single oral doses of ketoprofen capsules or a novel sustained-release pellet formulation. Biopharm Drug Dispos. 1984; 5:203-9. [IDIS 190442] [PubMed 6487749]

78. Upton RA, Williams RL, Buskin JN et al. Effects of probenecid on ketoprofen kinetics. Clin Pharmacol Ther. 1982; 31:705-12. [IDIS 152190] [PubMed 7075118]

79. Kaye CM, Sankey MG, Holt JE. A high-pressure liquid chromatographic method for the assay of ketoprofen in plasma and urine, and its application to determining the urinary excretion of free and conjugated ketoprofen following oral administration of Orudis to man. Br J Clin Pharmacol. 1981; 11:395-8. [IDIS 142564] [PubMed 7259935]

80. Verbeeck RK, Blackburn JL, Loewen GR. Clincial pharmacokinetics of non-steroidal anti-inflammatory drugs. Clin Pharmacokinet. 1983; 8:297-331. [IDIS 173932] [PubMed 6352138]

81. Braverman AM, Ghosh D, Kaye CM et al. The pharmacokinetics of ketoprofen in geriatric subjects given a single oral dose of a controlled release formulation. Br J Clin Pharmacol. 1985; 20:298P.

82. Wallis WJ, Simkin PA. Antirheumatic drug concentrations in human synovial fluid and synovial tissue: observations on extravascular pharmacokinetics. Clin Pharmacokinet. 1983; 8:496-522. [IDIS 179997] [PubMed 6360465]

83. Merck Sharp & Dohme. Indocin prescribing information. West Point, PA; 1985 Oct.

84. Jelie-Ivanovic Z, Majkie-Singh N, Spasoc S et al. Interference by analgesic and antirheumatic drugs in 25 common laboratory assays. J Clin Chem Clin Biochem. 1985; 23:287-92. [PubMed 3874926]

85. Weutersz TB (Wyeth Laboratories; Philadelphia, PA). Letter to members of P&T committees; 1986.

86. Weinberger M. Analgesic sensitivity in children with asthma. Pediatrics. 1978; 62(Suppl):910-5. [IDIS 118712] [PubMed 103067]

87. Settipane GA. Adverse reactions to aspirin and related drugs. Arch Intern Med. 1981; 141:328-32. [IDIS 142745] [PubMed 7008734]

88. Pleskow WW, Stevenson DD, Mathison DA et al. Aspirin desensitization in aspirin-sensitive asthmatic patients: clinical manifestations and characterization of the refractory period. J Allergy Clin Immunol. 1982; 69(1 Part 1):11-9. [IDIS 144037] [PubMed 7054250]

89. VanArsdel PP Jr. Aspirin idiosyncrasy and tolerance. J Allergy Clin Immunol. 1984; 73:431-3. [IDIS 183975] [PubMed 6423718]

90. Stevenson DD. Diagnosis, prevention, and treatment of adverse reactions to aspirin and nonsteroidal anti-inflammatory drugs. J Allergy Clin Immunol. 1984; 74(4 Part 2):617-22. [IDIS 193318] [PubMed 6436354]

91. Stevenson DD, Mathison DA. Aspirin sensitivity in asthmatics: when may this drug be safe? Postgrad Med. 1985; 78:111-3, 116-9. (IDIS 205854)

92. Settipane GA. Aspirin and allergic diseases: a review. Am J Med. 1983; 74(Suppl):102-9. [IDIS 171763] [PubMed 6344621]

93. Anon. Ketoprofen. Med Lett Drugs Ther. 1986; 28:61-2. [PubMed 3713638]

94. Atkinson LK, Goodship THJ, Ward MK. Acute renal failure associated with acute pyelonephritis and consumption of non-steroidal anti-inflammatory drugs. BMJ. 1986; 292:97-8. [IDIS 209878] [PubMed 3080108]

95. Widmark RM, Vavra I. Liver safety of ketoprofen (Orudis). J Clin Pharmacol. 1984; 24:401.

96. Hart FD, Huskisson EC, Answell BM. Non-steroidal anti-inflammatory analgesics. In: Hart FD, ed. Drug treatment of the rheumatic diseases. 2nd ed. Balgowlah, NSW Australia: ADIS Press; 1982:7-60.

97. Renier JC, Boasson M. Clinical use of ketoprofen: a retrospective study. Rheumatol Rehabil. 1976; 15(Suppl):81-2. [PubMed 132695]

98. Sany J, Serre H. A study of ketoprofen in rheumatoid arthritis. Rheumatol Rehabil. 1976; 15(Suppl):67-70. [PubMed 935737]

99. Spongsveen K, Aune A, Brath HK et al. An interim report on an open multicentre long-term study of ketoprofen (Orudis) in rheumatic diseases. Rheumatol Rehabil. 1978; 17(Suppl):71-7.

100. Zutshi D, Mason M. Ketoprofen in rheumatoid arthritis: its tolerance and therapeutic effect. Scand J Rheumatol. 1976; 5(Suppl 14):77-84. [PubMed 935826]

101. Fossgreen J, Kirchheiner B, Petersen FO et al. Clinical evaluation of ketoprofen (19.583 R.P.) in rheumatoid arthritis. Scand J Rheumatol. 1976; 5(Suppl 14):93-8.

102. Peltola P. Long-term treatment with ketoprofen in rheumatoid arthritis. Scand J Rheumatol. 1976; 5(Suppl 14):115-7.

103. Cathcart BJ, Vince JD, Gordon AJ et al. Studies on 2-(3-benzoylphenyl) propionic acid (Orudis). Ann Rheum Dis. 1973; 32:62-5. [IDIS 32133] [PubMed 4568350]

104. Baker PG, Goulton J. Ketoprofen (Orudis) twice daily dosage in arthritis and tissue injuries: a general practice study. J Int Med Res. 1979; 7:344-50. [PubMed 499641]

105. Mason J, Bolton MS. A general practice assessment of Alrheumat (ketoprofen) in the treatment of rheumatic conditions. Br J Clin Pract. 1977; 31:127-34. [IDIS 88714] [PubMed 337997]

106. Willans MJ, Digby JW, Topp JR et al. Long-term treatment of arthritic disease with ketoprofen (Orudis): a Canadian multi-centre evaluation. Curr Ther Res. 1979; 25:35-45.

107. Willans MJ, Wehner SE, Bourgouin J et al. Double-blind study of ketoprofen capsules and enteric-coated tablets in the maintenance treatment of patients with rheumatoid arthritis. Curr Ther Res. 1985; 38:870-9.

108. Acqaviva B, Cayla J, Delcambre B et al. Etude clinique du bi-profenid en pratique rhumatologique. (French; with English abstract.) Sem Hop Paris. 1983; 59:3229-34.

109. Russell AS, Labelle JL. A double-blind crossover study of ketoprofen enteric-coated and ketoprofen non-enteric-coated tablets in patients with ankylosing spondylitis, osteoarthritis and rheumatoid arthritis. Curr Ther Res. 1983; 33:185-91.

112. Marcolongo R, Rubegni M, Provvedi D et al. A double-blind, interpatient comparison of plain and slow-release ketoprofen in osteoarthritis. Int J Clin Pharmacol Ther Toxicol. 1984; 22:377-81. [PubMed 6381334]

113. Grahame R. Ketoprofen–clinical efficacy. Rheumatol Rehabil. 1976; 15(Suppl):22-5.

114. O’Brien WM, Grunwaldt E. Ketoprofen in the treatment of rheumatoid arthritis. Scand J Rheumatol. 1976; 5(Suppl 14):105-10.

115. Howard DLG. A double-blind crossover evaluation of ketoprofen (Orudis) and placebo in rheumatoid arthritis with assessment of long-term tolerance. J Int Med Res. 1978; 6:300-5. [PubMed 357231]

116. Howard DLG. A double-blind crossover evaluation of ketoprofen (Orudis) and placebo in rheumatoid arthritis with assessment of long-term tolerance. Curr Ther Res. 1978; 23:678-84.

117. Sacchetti G, Camera P, Paolo Rossi A et al. Injectable ketoprofen vs acetylsalicylic acid for the relief of severe cancer pain: a double-blind, crossover trial. Drug Intell Clin Pharm. 1984; 18:403-6. [IDIS 184691] [PubMed 6373214]

118. Lussier A, Camerlain M, Menard H et al. A double-blind cross-over evaluation of ketoprofen and aspirin in rheumatoid arthritis. Scand J Rheumatol. 1976; 5(Suppl 14): 99-104.

119. O’Brien WM, Sakofsky HY, Schmid FR et al. A controlled double-blind study of ketoprofen versus aspirin in the treatment of rheumatoid arthritis. Curr Ther Res. 1977; 21:689-96.

120. Kennedy AC. Ketoprofen in the treatment of rheumatoid arthritis. Rheumatol Rehabil. 1976; 15(Suppl):34-6.

121. Cooper SA, Gelb S, Goldman EH et al. An analgesic relative potency assay comparing ketoprofen and aspirin in postoperative dental pain. Adv Ther. 1984; 1:410-8.

122. Peltola P. A double-blind cross-over study of ketoprofen and phenylbutazone in rheumatoid arthritis. Scand J Rheumatol. 1976; 5(Suppl 14):111-3.

123. Sydnes O, Brath HK, Haerum LB et al. Clinical evaluation of ketoprofen (Orudis) in rheumatoid arthritis. Scand J Rheumatol. 1976; 5(Suppl 14):119-22. [PubMed 935823]

124. Ricciardi S, Filosa E. Il ketoprofen nelle reumoartropatie in eta geriatrica: ricerca a doppio cieco. (Italian; with English abstract.) Clin Ter. 1977; 83:593-608.

125. Sydnes OA, Brath HK, Haerum LB et al. Clinical evaluation of ketoprofen (Orudis) in rheumatoid arthritis: results of a multi-centre double-blind trial against phenylbutazone. Rheumatol Rehabil. 1976; 15(Suppl):43-9. [PubMed 1082624]

126. Huskisson EC. Rheumatoid arthritis. In: Hart FD, ed. Drug treatment of the rheumatic diseases. 2nd ed. Balgowlah, NSW Australia: ADIS Press; 1982:124-130.

127. Griffin AJ, Grahame R, Bloch M et al. Ketoprofen: double-blind cross-over study with indomethacin administered as a combined suppository/capsule regime in patients with rheumatoid arthritis: a preliminary report. Rheumatol Rehabil. 1978; 17(Suppl):84-9.

128. Huskisson EC. Osteoarthritis (Osteoarthrosis). In: Hart FD, ed. Drug treatment of the rheumatic diseases. 2nd ed. Balgowlah, NSW Australia: ADIS Press; 1982:131-4.

129. Viara M, Franchi R, Liverta C et al. Ketoprofen and indomethacin in the treatment of rheumatoid arthritis: a double-blind cross-over trial. Eur J Clin Pharmacol. 1975; 8:205-8. [IDIS 55025] [PubMed 786679]

130. Hart FD. Gout: treatment of the acute attack. In: Hart FD, ed. Drug treatment of the rheumatic diseases. 2nd ed. Balgowlah, NSW Australia: ADIS Press; 1982:135-8.

131. El-Ghobarey AF, Rennie JAN, Hadidi T et al. A comparative trial of large doses of ketoprofen and indomethacin in the treatment of rheumatoid arthritis. Curr Med Res Opin. 1976; 4:432-5. [PubMed 793780]

132. Gyory AN, Bloch M, Burry HC et al. Orudis in management of rheumatoid arthritis and osteoarthrosis of the hip: comparison with indomethacin. Br Med J. 1972; 4:398-400. [IDIS 30856] [PubMed 4564764]

133. Juvakoski T, Lassus A. A double-blind cross-over evaluation of ketoprofen and indomethacin in Reiter’s disease. Scand J Rheumatol. 1982; 11:106-8. [PubMed 7046034]

134. Montrone F, Fumagalli M, Pellegrini P et al. A double-blind cross-over evaluation of ketoprofen (Orudis) and ibuprofen in the management of rheumatoid arthritis. Rheumatol Rehabil. 1979; 18:114-8. [PubMed 377448]

135. Calin A, Bennett RM, Sukhupunyaraksa S et al. Double-blind, multi-centre parallel trial of ketoprofen and ibuprofen in the treatment of rheumatoid arthritis. J Rheumatol. 1977; 4:153-7. [PubMed 328880]

136. Mills SB, Bloch M, Bruckner FE. Double-blind cross-over study of ketoprofen and ibuprofen in management of rheumatoid arthritis. Br Med J. 1973; 4:82-84. [IDIS 45222] [PubMed 4583184]

137. Huskisson EC, Woolf DL, Balme HW et al. Four new anti-inflammatory drugs: responses and variations. Br Med J. 1976; 1:1048-9. [IDIS 60303] [PubMed 773499]

138. Saxena RP, Saxena U. A comparative trial of ketoprofen and ibuprofen in patients with rheumatic disease. Curr Med Res Opin. 1978; 5:484-8. [PubMed 350500]

139. Wollheim FA, Lindroth Y, Sjoblom KG. A comparison of ketoprofen and naproxen in rheumatoid arthritis. Rheumatol Rehabil. 1978; 17(Suppl):78-83.

140. Bhettay E, Thomson AJG. Double-blind study of ketoprofen and indomethacin in juvenile chronic arthritis. S Afr Med J. 1978; 54:276-8. [IDIS 93720] [PubMed 362571]

141. Brewer EJ, Giannini EH, Baum J et al. Ketoprofen (Orudis) in the treatment of juvenile rheumatoid arthritis: a segment I study. J Rheumatol. 1982; 9:144-8. [PubMed 7045361]

142. Charlot J, Villiaumey J. A comparative study of benoxaprofen and ketoprofen in ankylosing spondylitis. Eur J Rheumatol. 1982; 5:277-81.

143. Treadwell BLJ, Tweed JM. Ketoprofen (Orudis) in ankylosing spondylitis. N Z Med J. 1975; 81:411-3. [IDIS 56279] [PubMed 1099489]

144. Renier JC, Fournier M, Loyau G et al. Spondylarthrite ankylosante: essai comparatif de deux anti-inflammatoires non-steroidiens, le pirprofene et le ketoprofene. (French; with English abstract.) Nouv Presse Med. 1982; 11:2494-6.

145. Willans MJ, Labelle JL, Forget JP. A double blind crossover study of ketoprofen enteric- and non-enteric-coated tablets in rheumatoid arthritis. Curr Ther Res. 1982; 31:913-21.

146. Jessop JD. Double-blind study of ketoprofen and phenylbutazone in ankylosing spondylitis. Rheumatol Rehabil. 1976; 15(Suppl):37-42. [PubMed 1082622]

147. Cardoe N. Double-blind cross-over study of ketoprofen and phenylbutazone in patients with chronic osteoarthrosis of the hip. Rheumatol Rehabil. 1976; 15(Suppl):27-33.

148. Hubault A, Caroit M, Forette B et al. Double-blind trial of ketoprofen compared with placebo in osteoarthrosis of the hip. Rheumatol Rehabil. 1976; 15(Suppl):52-6.

149. Russell AS, LeMorvan P. Double-blind comparison between ketoprofen capsules four times daily and enteric-coated tablets twice daily in patients with osteoarthritis. Curr Ther Res. 1985; 38:599-605.

150. Goulton J, Baker PG, Wilkinson MA. A multicentre hospital study of Orudis in osteoarthritis of the hip and knee. Br J Clin Pract. 1979; 33:26-8. [IDIS 120383] [PubMed 435358]

151. Lang E, Steger W. A comparative study of efficacy and tolerability of ketoprofen and piroxicam. Br J Clin Pract. 1981; 35:267. [IDIS 137861] [PubMed 7032566]

152. Martio J, Uuspaa V. Ketoprofen and pethidine in the treatment of post-operative pain following synovectomy: a double-blind trial on rheumatoid arthritis patients. Br J Clin Pract. 1981; 35:265. [IDIS 137859] [PubMed 7032565]

153. Caroit M, Forette B, Hubault A et al. Double-blind study of ketoprofen against a placebo in osteoarthritis of the hip. Scand J Rheumatol. 1976; 5(Suppl 14):123-7.

154. Famaey JP, Colinet E. A double-blind trial of ketoprofen in the treatment of osteoarthritis of the hip. Scand J Rheumatol. 1976; 5(Suppl 14):129-32. [PubMed 824724]

155. Zutshi DW, Stern D, Bloch M et al. Ketoprofen: double-blind cross-over study with indomethacin in patients with rheumatoid arthritis. Rheumatol Rehabil. 1974; 13:10-6. [PubMed 4604659]

156. Serry MM. A low-dosage ketoprofen preparation in the management of osteoarthrosis of the knee joint. J Int Med Res. 1980; 8:388-90. [PubMed 7439515]

157. Ring EFJ, Dieppe PA, Bacon PA. The thermographic assessment of inflammation and anti-inflammatory drugs in osteoarthritis. Br J Clin Pract. 1981; 35:263-4. [IDIS 137858] [PubMed 7032564]

158. Bresnihan FP, Grahame R, Burry HC. Ketoprofen in the management of osteoarthritis of the hip: comparison with phenylbutazone. Rheumatol Rehabil. 1974; 13:125-31. [PubMed 4608933]

159. van der Bijl P. Non-steroidal anti-inflammatory drugs (NSAID’s) as analgesics in dentistry—a review. Tydskr Tandhelkd Ver S Afr. 1983; 38:419-26.

160. Benoit P, Michelet FX, Pinsolle J et al. Interet therapeutique d’un nouvel anti-inflammatoire: le ketoprofene en chirurgerie maxillo-faciale et en stomatologie. Rev Odontostomatol Midi Fr. 1980; 38:177-85. [PubMed 6939044]

161. Kauppila A, Puolakka J, Ylikorkala O. The relief of primary dysmenorrhea by ketoprofen and indomethacin. Prostaglandins. 1979; 18:647-53. [PubMed 531231]

162. Zutshi DW, Marr S, Bloch M et al. Double-blind cross-over study of Orudis and placebo in fifty patients with rheumatoid arthritis. Rheumatol Rehabil. 1973; 12:62-7. [PubMed 4582347]

163. Anon. Nonsteroidal anti-inflammatory drugs for rheumatoid arthritis. Med Lett Drugs Ther. 1980; 22:29-31. [IDIS 111632] [PubMed 7366532]

164. Gleeson S, Sorbie J. Efficacy of ketoprofen in treating primary dysmenorrhea. Can Med Assoc J. 1983; 129:842-4. [PubMed 6351994]

165. Toft B, Christophersen J, Christensen N et al. A double-blind, crossover study of a sustained-release tablet of ketoprofen and normal ketoprofen capsules in the treatment of patients with osteoarthritis. Curr Med Res Opin. 1985; 9:708-12. [PubMed 3907991]

166. Turek MD, Baird WM, Larouche SJ et al. Comparison of ketoprofen, acetaminophen plus codeine and placebo in post-operative analgesia. Clin Pharmacol Ther. 1986; 39:232.

167. Magrini M, Rivolta G, Movilia PG et al. Successful treatment of biliary colic with intravenous ketoprofen or lysine acetylsalicylate. Curr Med Res Opin. 1985; 9:454-60. [PubMed 3928264]

168. Morley KD, Bernstein RM, Hughes GRV et al. A comparative trial of a controlled-release formulation of ketoprofen (″Oruvail’) and a conventional capsule formulation of ketoprofen (″Orudis’) in patients with osteoarthritis of the hip. Curr Med Res Opin. 1984; 9:28-34. [PubMed 6723349]

169. Ryckelynck JP, Landru I, Dapogny C et al. Traitement de la colique nephretique par le ketoprofene: a propos de 39 episodes chez 37 patients. LARC Med. 1984; 4:453-4. [PubMed 6503567]

170. Magrini M, Pavesi G, Liverta C et al. Intravenous ketoprofen in renal colic: a placebo-controlled pilot study. Clin Ther. 1984; 6:483-7. [PubMed 6432325]

171. Cofini S, Agopovich G, Arcuri C. Osservazioni cliniche sull’utilizzazione del ketoprofene in odontostomatologia. Riv Odontostomatol Implantoprotesi. 1984; 2:57-61.

172. Leopold M. A double-blind cross-over comparative study of ketoprofen versus naproxen in the treatment of osteo-arthritis of the knee. Scand J Rheumatol. 1980; 33(Suppl):22.

173. Mehlisch D, Frakes L, Cavaliere MB et al. Double-blind parallel comparison of single oral doses of ketoprofen, codeine, and placebo in patients with moderate to severe dental pain. J Clin Pharmacol. 1984; 24:486-92. [IDIS 193926] [PubMed 6392354]

174. Kantor T, Cavaliere MB, Hopper M et al. A double-blind parallel comparison of ketoprofen, codeine, and placebo in patients with moderate to severe postpartum pain. J Clin Pharmacol. 1984; 24:228-34. [IDIS 187805] [PubMed 6747019]

175. Serre H, Sany J. Etude clinique du ketoprofene en rhumatologie. Rhumatologie. 1973; (May):217-22.

176. Muller-Fassbender H, Reiter W, Eveld H. Open multicentre long-term trial (3 years) on efficacy and tolerance of ketoprofen (Orudis capsules) in rheumatology: final assessment. Curr Ther Res. 1984; 36:1221-7.

177. Syntex Puerto Rico, Inc. Naprosyn prescribing information. Humacao, PR; 1985 Jun.

178. Barthelemy C. Etude des effets secondaires du ketoprofene sur la muqueuse gastro-duodenale: comparaison de deux formes orales. (French; with English abstract.) Sem Hop Paris. 1983; 59:3258-60.

179. Ranlov PJ, Nielsen SP, Barenholdt O. Faecal blood loss during administration of acetylsalicylic acid, ketoprofen and two new ketoprofen sustained-release compounds. Scand J Rheumatol. 1983; 12:280-4. [PubMed 6604940]

180. Caruso I, Porro GB. Gastroscopic evaluation of anti-inflammatory agents. Br Med J. 1980; 280:75-7. [IDIS 116086] [PubMed 7353130]

181. Pemberton RE, Strand LJ. A review of upper-gastrointestinal effects of the newer nonsteroidal antiinflammatory agents. Dig Dis Sci. 1979; 24:53-64. [IDIS 109764] [PubMed 371938]

182. Magnusson B, Solvell L, Arvidsson B. A comparative study of gastrointestinal bleeding during administration of ketoprofen and naproxen. Scand J Rheumatol. 1977; 6:62-4. [PubMed 322269]

183. Lussier A, Arsenault A. Gastrointestinal blood loss induced by ketoprofen, aspirin and placebo (preliminary report). Scand J Rheumatol. 1976; 5(Suppl 14):73-6.

184. Rahbek I. Gastroscopic evaluation of the effect of a new anti-rheumatic compound, ketoprofen (19.583 R.P.), on the human gastric mucosa: a double-blind cross-over trial against acetylsalicylic acid. Scand J Rheumatol. 1976; 5(Suppl 14):63-72.

185. Peltola P. Ketoprofen experiences. Rheumatol Rehabil. 1978; 17(Suppl):109-11.

186. Arsenault A, Lussier A. Gastro-intestinal microbleeding under acetylsalicylic acid, ketoprofen and placebo. Rheumatol Rehabil. 1976; 15(Suppl):87-93. [PubMed 935738]

187. Ducret F, Pointet P, Martin D et al. Insuffisance renale aigue reversible induite par le ketoprofene. Nephrologie. 1982; 3:105-6. [PubMed 7121702]

188. Umez-Eronini EM. Conjunctivitis due to ketoprofen. Lancet. 1978; 2:737. [IDIS 87929] [PubMed 80660]

189. Frith P, Dolovich J, Hargreave FE. Life-threatening asthma, urticaria, and angioedema after ketoprofen. Lancet. 1978; 2:847-8. [IDIS 90067] [PubMed 81404]

190. Clerc D, Delfraissy JF, Salliere D et al. Insuffisance renale aigue sous ketoprofene et clometacine. (French; with English abstract.) Sem Hop Paris. 1983; 59:1613-5.

191. Avery GS, Heel RC, Speight TM. Appendix B: guide to adverse drug reactions. In: Avery GS, ed. Drug treatment: principles and practice of clinical pharmacology and therapeutics. 2nd ed. Sydney: ADIS Press; 1980:1224-51.

192. Carmichael J, Shankel SW. Effects of nonsteroidal anti-inflammatory drugs on prostaglandins and renal function. Am J Med. 1985; 78:992-9. [IDIS 201198] [PubMed 2861741]

193. Caramelo C, Lopez-Novoa JM. Renal syndromes and nonsteroidal antiinflammatory drugs. N Engl J Med. 1984; 311:194. [PubMed 6738607]

194. Robert A. Cytoprotection by prostaglandins. Gastroenterology. 1979; 77:761-7. [PubMed 38173]

195. Blackshear JL, Davidman M, Stillman MT. Identification of risk for renal insufficiency from nonsteroidal anti-inflammatory drugs. Arch Intern Med. 1983; 143:1130-4. [IDIS 171342] [PubMed 6860044]

196. Momma K, Hagiwara H, Konishi T. Constriction of fetal ductus arteriosus by non-steroidal anti-inflammatory drugs: study of additional 34 drugs. Prostaglandins. 1984; 28:527-36. [PubMed 6522619]

197. Miller TA, Jacobson ED. Gastrointestinal cytoprotection by prostaglandins. Gut. 1979; 20:75-87. [PubMed 367886]

198. Clive DM, Stoff JS. Renal syndromes associated with nonsteroidal antiinflammatory drugs. N Engl J Med. 1984; 310:563-72. [IDIS 181748] [PubMed 6363936]

199. Adams DH, Michael J, Bacon PA et al. Non-steroidal anti-inflammatory drugs and renal failure. Lancet. 1986; 1:57-9. [IDIS 209841] [PubMed 2867313]

200. Langman MJS, Morgan L, Worrall A. Use of anti-inflammatory drugs by patients admitted with small or large bowel perforations and haemorrhage. BMJ. 1985; 290:347-9. [IDIS 196241] [PubMed 3917814]

201. McDowell IFW, McConnell JB. Cholinergic crisis in myasthenia gravis precipitated by ketoprofen. BMJ. 1985; 291:1094. [PubMed 20742533]

202. O’Brien JD, Burnham WR. Bleeding from peptic ulcers and use of non-steroidal anti-inflammatory drugs in the Romford area. BMJ. 1985; 291:1609-10. [IDIS 209391] [PubMed 3935207]

203. Guidoboni R. Uncontrolled clinical trial on gastric side effects of slow-release ketoprofen lysine. Curr Ther Res. 1983; 34:839-43.

204. Zipser RD, Henrich WL. Implications of nonsteroidal anti-inflammatory drug therapy. Am J Med. 1986; 80(Suppl 1A):78-84. [IDIS 212036] [PubMed 3946427]

205. Kantor TA. Ketoprofen: a review of its pharmacologic and clinical properties. Pharmacotherapy. 1986; 6:93-102. [IDIS 394817] [PubMed 3526298]

206. Bennett RM. Management of rheumatoid arthritis. Compr Ther. 1979; 5:23-35. [PubMed 487729]

207. Bendix T, Schmidt I, Rasmussen KJE et al. Diclofenac (Voltaren) and ketoprofen (Orudis) in rheumatoid arthritis: a randomized double-blind multicenter trial. Curr Ther Res. 1983; 33:192-9.

208. Henrich WL. Nephrotoxicity of nonsteroidal anti-inflammatory agents. Am J Kidney Dis. 1983; 2:478-84. [PubMed 6823966]

209. Wilson F. (Wyeth Laboratories, Philadelphia, PA): Personal communication; 1986 Aug.

210. Reviewers’ comments (personal observations); 1986 Aug.

211. Teule M (Rhone-Poulenc Sante, Paris): Personal communication; 1986 Aug.

212. Larizza D, Colombo A, Lorini R et al. Ketoprofen causing pseudotumor cerebri in Bartter’s syndrome. N Engl J Med. 1979; 300:796. [PubMed 423914]

213. Vale JA, Meredith TJ. Acute poisoning due to non-steroidal anti-inflammatory drugs: clinical features and management. Med Toxicol. 1986; 1:12-31. [IDIS 221559] [PubMed 3537613]

214. Kimberly RP, Bowden RE, Keiser HR et al. Reduction of renal function by newer nonsteroidal anti-inflammatory drugs. Am J Med. 1978; 64:804-7. [PubMed 645744]

215. Corwin HL, Bonventre JV. Renal insufficiency associated with nonsteroidal anti-inflammatory agents. Am J Kidney Dis. 1984; 4:147-52. [PubMed 6475945]

216. Ellison NM, Servi RJ. Acute renal failure and death following sequential intermediate-dose methotrexate and 5-FU: a possible adverse effect due to concomitant indomethacin administration. Cancer Treat Rep. 1985; 69:342-3. [IDIS 198404] [PubMed 3978662]

217. Singh RR, Malaviya AN, Pandey JN et al. Fatal interaction between methotrexate and naproxen. Lancet. 1986; 1:1390. [IDIS 217293] [PubMed 2872507]

218. Day RO, Graham GG, Champion GD et al. Anti-rheumatic drug interactions. Clin Rheum Dis. 1984; 10:251-75. [PubMed 6150784]

219. Daly HM, Scott GL, Boyle J et al. Methotrexate toxicity precipitated by azapropazone. Br J Dermatol. 1986; 114:733-5. [IDIS 217458] [PubMed 3718865]

220. Mikami T, Miyasaka K. Effects of several anti-inflammatory drugs on the various parameters involved in the inflammatory response in rat carrageenin-induced pleurisy. Eur J Pharmacol. 1983; 95:1-12. [PubMed 6583058]

221. Hansten PD, Horn JR. Methotrexate interactions: ketoprofen (Orudis). Drug Interact Newsl. 1986; 6(Updates):U5-6.

222. Hansten PD, Horn JR. Diuretics and non-steroidal anti-inflammatory drugs. Drug Interact Newsl. 1986; 6:27-9.

223. O’Brien WM, Grunwaldt E. Ketoprofen in the treatment of rheumatoid arthritis: double-blind, cross-over placebo comparison. Scand J Rheumatol. 1976; 5(Suppl 14):105-10.

224. Paulus HE, Vavra I. Safety profile of ketoprofen: the US clinical experience. In: Proceedings of the Ketoprofen Summit Conference, 16th World Conference of Rheumatology; Sidney, 1985. London: Medicine Communications International Ltd; 1986:43-56.

225. Walker JL. Interrelationships of SRS-A production and arachidonic acid metabolism in human lung tissue. Adv Prostaglandin Thromboxane Res. 1980; 6:115-9. [PubMed 6155760]

226. Walker JR, Harvey J. Actions of anti-inflammatory drugs on leukotriene and prostaglandin metabolism: relationship to asthma and other hypersensitivity reactions. Adv Inflammation Res. 1984; 6:227-38.

227. McCrea JD, Telford AM, Kaye CM et al. A comparison of plasma and synovial fluid profiles of standard and controlled-release formulations of ketoprofen in patients with rheumatoid arthritis. Curr Med Res Opin. 1986; 10:73-81. [PubMed 3519094]

228. Heusse D, Populaire P. The metabolic disposition of3H-ketoprofen in various species. Paper presented at Ketoprofen Symposium, 14th International Congress of Rheumatology; San Francisco, 1977.

229. Singer L, Imbs JL, Danion JM et al. Risque d’intoxication par le lithium en cas de traitement associé par les anti-inflammatoires non steroidiens. (French; with English abstract.) Therapie. 1981; 36:323-6.

230. Windeck R, Bock KD, Jakubowski HD. Irreversibles Versagen einer transplantierten Niere, ausgelöst durch Ketoprofen? (German; with English abstract.) Dtsch Med Wochenschr. 1983; 108:720-1.

231. Maiche AG. Acute renal failure due to concomitant action of methotrexate and indomethacin. Lancet. 1986; 1:1390. [IDIS 217292] [PubMed 2872506]

232. Wyeth Laboratories Inc. Orudis (ketoprofen) product monograph. Philadelphia, PA; 1986 Jul.

233. Singh G, Triadafilopoulos G. Epidemiology of NSAID induced gastrointestinal complications. J Rheumatol. 1999; 26(suppl 56):18-24.

234. Hébert JG, Le Morvan P, Bourgouin J. Double-blind comparison of ketoprofen and mefenamic acid in the treatment of primary dysmenorrhea. Clin Ther. 1986; 8:329-35. [PubMed 3521860]

235. Sunshine A, Zighelboim I, Laska E et al. A double-blind, parallel comparison of ketoprofen, aspirin, and placebo in patients with postpartum pain. J Clin Pharmacol. 1986; 26:706-11. [IDIS 222652] [PubMed 3540033]

236. Duranceau JA, Lacoste P, Bourgouin J et al. Double-blind comparison of ketoprofen and placebo in the treatment of sprains and strains. Clin Ther. 1986; 8:187-95. [PubMed 3698066]

237. Sennesael J, Van den Houte K, Verbeelen D. Reversible membranous glomerulonephritis associated with ketoprofen. Clin Nephrol. 1986; 26:213-5. [PubMed 3780072]

238. Thyss A, Viens P, Caldani C et al. Efficacíte antalgique dué ketopròfene en perfusion continue dans les douleurs rebelles paré metastases osseuses. Presse Med. 1987; 16:638. [PubMed 2952987]

239. Lopez Soriano F. Ketoprofen y nefopan en el tratamiento del dolor postoperatorio. Rev Esp Anestesiol Reanim. 1986; 33:291-3. [PubMed 3786880]

240. Flessner MF, Knight H. Prolongation of prothrombin time and severe gastrointestinal bleeding associated with combined use of warfarin and ketoprofen. JAMA. 1988; 259:353. [IDIS 236668] [PubMed 3257277]

241. Palmer JF. Letter sent to Bathish J, of Wyeth-Ayerst Laboratories regarding labeling revisions about gastrointestinal adverse reactions to Orudis (ketoprofen). Rockville, MD: Food and Drug Administration, Division of Oncology and Radiopharmaceutical Drug Products; 1988 Sep.

242. Food and Drug Administration. Labeling revisions for NSAIDs. FDA Drug Bull. 1989; 19:3-4.

243. Searle. Cytotec (misoprostol) prescribing information. Skokie, IL; 1989 Jan.

244. Anon. Drugs for rheumatoid arthritis. Med Lett Drugs Ther. 2000; 42:57-64. [PubMed 10887424]

245. Soll AH, Weinstein WM, Kurata J et al. Nonsteroidal anti-inflammatory drugs and peptic ulcer disease. Ann Intern Med. 1991; 114:307-19. [IDIS 277370] [PubMed 1987878]

246. Corticosteroid interactions: nonsteroidal anti-inflammatory drugs (NSAIDs). In: Hansten PD, Horn JR. Drug interactions and updates. Vancouver, WA: Applied Therapeutics, Inc; 1993:562.

247. Garcia Rodriguez LA, Jick H. Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs. Lancet. 1994; 343:769-72. [IDIS 328176] [PubMed 7907735]

248. Langman MJS, Weil J, Wainwright P et al. Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs. Lancet. 1994; 343:1075-8. [IDIS 329994] [PubMed 7909103]

249. Bateman DN. NSAIDs: time to re-evaluate gut toxicity. Lancet. 1994; 343:1051-2. [IDIS 329990] [PubMed 7909094]

250. Hollander D. Gastrointestinal complications of nonsteroidal anti-inflammatory drugs: prophylactic and therapeutic strategies. Am J Med. 1994; 96:274-81. [IDIS 328041] [PubMed 8154516]

251. Schubert TT, Bologna SD, Nensey Y et al. Ulcer risk factors: interaction between Helicobacter pylori infection, nonsteroidal use, and age. Am J Med. 1993; 94:413-8. [IDIS 314155] [PubMed 8475935]

252. Shorr RI, Ray WA, Daugherty JR et al. Concurrent use of nonsteroidal anti-inflammatory drugs and oral anticoagulants places elderly persons at high risk for hemorrhagic peptic ulcer disease. Arch Intern Med. 1993; 153:1665-70. [IDIS 318791] [PubMed 8333804]

253. Piper SM, Ray WA, Daugherty JR et al. Corticosteroid use and peptic ulcer disease: role of nonsteroidal anti-inflammatory drugs. Ann Intern Med. 1991; 114:735-40. [IDIS 280191] [PubMed 2012355]

254. Nonsteroidal anti-inflammatory drug interactions: lithium-diclofenac. In: Hansten PD, Horn JR. Drug Interactions and updates. Vancouver, WA: Applied Therapeutics, Inc; 1993:607.

255. Bateman DN, Kennedy JG. Non-steroidal anti-inflammatory drugs and elderly patients: the medicine may be worse than the disease. BMJ. 1995; 310:817-8. [IDIS 345154] [PubMed 7711609]

264. Hawkey CJ. COX-2 inhibitors. Lancet. 1999; 353:307-14. [IDIS 418284] [PubMed 9929039]

265. Kurumbail RG, Stevens AM, Gierse JK et al. Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature. 1996; 384-644-8.

266. Riendeau D, Charleson S, Cromlish W et al. Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays. Can J Physiol Pharmacol. 1997; 75:1088-95. [PubMed 9365818]

267. DeWitt DL, Bhattacharyya D, Lecomte M et al. The differential susceptibility of prostaglandin endoperoxide H synthases-1 and -2 to nonsteroidal anti-inflammatory drugs; aspirin derivatives as selective inhibitors. Med Chem Res. 1995; 5:325-43.

268. Cryer B, Dubois A. The advent of highly selective inhibitors of cyclooxygenase—a review. Prostaglandins Other Lipid Mediators. 1998; 56:341-61. [PubMed 9990677]

269. Simon LS. Role and regulation of cyclooxygenase-2 during inflammation. Am J Med. 1999; 106(Suppl 5B):37-42S.

270. Wolfe MM, Lichtenstein DR, Singh G. Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med. 1999; 340:1888-99. [IDIS 426864] [PubMed 10369853]

271. Morrison BW, Daniels SE, Kotey P et al. Rofecoxib, a specific cyclooxygenase-2 inhibitor, in primary dysmenorrhea: a randomized controlled study. Obstet Gynecol. 1999; 94:504-8. [IDIS 437014] [PubMed 10511349]

273. American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines.. Guidelines for the management of rheumatoid arthritis:2002 update. Arthritis Rheum. 2002; 46:328-46. [IDIS 476480] [PubMed 11840435]

274. Lanza FL, and the members of the Ad Hoc Committee on Practice Parameters of the American College of Gastroenterology. A guideline for the treatment and prevention of NSAID-induced ulcers. Am J Gastroenterol. 1998; 93:2037-46. [IDIS 417402] [PubMed 9820370]

275. in’t Veld BA, Ruitenberg A, Hofman A et al. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer’s disease. N Engl J Med. 2001; 345:1515-21. [PubMed 11794217]

276. Breitner JCS, Zandi PP. Do nonsteroidal antiinflammatory drugs reduce the risk of Alzheimer’s disease? N Engl J Med. 2001; 345:1567-8. Editorial.

277. McGeer PL, Schulzer M, McGeer EG. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer’s disease: a review of 17 epidemiologic studies. Neurology. 1996; 47:425-32. [IDIS 371394] [PubMed 8757015]

278. Beard CM, Waring SC, O’sBrien PC et al. Nonsteroidal anti-inflammatory drug use and Alzheimer’s disease : a case-control study in Rochester, Minnesota, 1980 through 1984. Mayo Clin Proc. 1998; 73:951-5. [IDIS 416502] [PubMed 9787743]

279. in’t Veld BA, Launer LJ, Hoes AW et al. NSAIDs and incident Alzheimer’s disease: the Rotterdam Study. Neurobiol Aging. 1998; 19:607-11. [PubMed 10192221]

280. Stewart WF, Kawas C, Corrada M et al. Risk of Alzheimer’s disease and duration of NSAID use. Neurology. 1997; 48:626-32. [IDIS 383303] [PubMed 9065537]

281. Pharmacia. Daypro (oxaprozin) caplets prescribing information. Chicago, IL; 2002 May.

282. Chan FKL, Hung LCT, Suen BY et al. Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis. N Engl J Med. 2002; 347:2104-10. [IDIS 490812] [PubMed 12501222]

283. Graham DY. NSAIDs, Helicobacter pylori, and Pandora’s box. N Engl J Med. 2002; 347:2162-4. [IDIS 490815] [PubMed 12501230]

284. Food and Drug Administration. Analysis and recommendations for agency action regarding non-steroidal anti-inflammatory drugs and cardiovascular risk. 2005 Apr 6.

285. Cush JJ. The safety of COX-2 inhibitors: deliberations from the February 16-18, 2005, FDA meeting. From the American College of Rheumatology web site (). Accessed 2005 Oct 12.

286. Novartis Pharmaceuticals. Diovan (valsartan) capsules prescribing information (dated 1997 Apr). In: Physicians’ desk reference. 53rd ed. Montvale, NJ: Medical Economics Company Inc; 1999:2013-5.

287. Rosebraugh C (Director, Division of Nonprescription Clinical Evaluation). Supplemental labeling request. From FDA web site (). Accessed Oct 2005.

288. McGettigan P, Henry D. Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of observational studies of selective and nonselective inhibitors of cyclooxygenase 2. JAMA. 2006; 296: 1633-44. [PubMed 16968831]

289. Kearney PM, Baigent C, Godwin J et al. Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ. 2006; 332: 1302-5. [PubMed 16740558]

290. Graham DJ. COX-2 inhibitors, other NSAIDs, and cardiovascular risk; the seduction of common sense. JAMA. 2006; 296:1653-6. [PubMed 16968830]

291. Merck & Co. Clinoril (sulindac) tablets prescribing information. Whitehouse Station, NJ; 2006 Feb.

294. Chou R, Helfand M, Peterson K et al. Comparative effectiveness and safety of analgesics for osteoarthritis. Comparative effectiveness review no. 4. (Prepared by the Oregon evidence-based practice center under contract no. 290-02-0024.) . Rockville, MD: Agency for Healthcare Research and Quality. 2006 Sep. Available at: .

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