Ketoprofen use while Breastfeeding
Drugs containing Ketoprofen: Orudis, Oruvail, Actron, Nexcede, Orudis KT
Ketoprofen Levels and Effects while Breastfeeding
Summary of Use during Lactation
Because of the low levels of ketoprofen in breastmilk and its short half-life, it is unlikely to adversely affect the breastfed infant. However, because there is no published experience with breastfeeding during ketoprofen use, other agents may be preferred, especially while nursing a newborn or preterm infant.
Drug Levels
Maternal Levels. Eighteen women were given ketoprofen 100 mg every 12 hours (average 2.69 mg/kg daily) intravenously for 2 to 3 days postpartum. One to 4 milk samples were collected between the 3rd and 4th dose of ketoprofen. Of the 61 samples collected, ketoprofen was undetectable (<20 mcg/L) in 17 of the samples. The authors assumed a milk concentration of 20 mcg/L for undetectable samples and calculated an average milk concentration of 57 mcg/L (range 20 to 177 mcg/L). A fully breastfed infant would receive an average dosage of 8.5 mcg/kg daily or 0.31% of the maternal weight-adjusted dosage.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Possible Effects on Lactation
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
Acetaminophen, Flurbiprofen, Ibuprofen, Indomethacin, Naproxen, Piroxicam
References
1. Jacqz-Aigrain E, Serreau R, Boissinot C et al. Excretion of ketoprofen and nalbuphine in human milk during treatment of maternal pain after delivery. Ther Drug Monit. 2007;29:815-8. PMID: 18043481
Ketoprofen Identification
Substance Name
CAS Registry Number
22071-15-4
Drug Class
- Analgesic Agents
- Nonsteroidal Antiinflammatory Agents
Administrative Information
LactMed Record Number
624
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
2008-07-16
Disclaimer
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
See Also...
- Ketoprofen use during Pregnancy
- Ketoprofen Consumer Information
- Breastfeeding Support Group
- Safe Medications during Breastfeeding
- Medicine use while Breastfeeding
- Medicine use during Pregnancy
Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.
