Ketoprofen use while Breastfeeding

Drugs containing Ketoprofen: Orudis, Oruvail, Actron, LidoProfen, Orudis KT, Nexcede

Ketoprofen Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although ketoprofen has low levels in breastmilk, one center reported that they had received reports of adverse renal and gastrointestinal side effects in breastfed infants whose mothers were taking ketoprofen. Other agents are preferred, especially while nursing a newborn or preterm infant.

Drug Levels

Maternal Levels. Eighteen women were given ketoprofen 100 mg every 12 hours (average 2.69 mg/kg daily) intravenously for 2 to 3 days postpartum. One to 4 milk samples were collected between the 3rd and 4th dose of ketoprofen. Of the 61 samples collected, ketoprofen was undetectable (<20 mcg/L) in 17 of the samples. The authors assumed a milk concentration of 20 mcg/L for undetectable samples and calculated an average milk concentration of 57 mcg/L (range 20 to 177 mcg/L). A fully breastfed infant would receive an average dosage of 8.5 mcg/kg daily or 0.31% of the maternal weight-adjusted dosage.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

All adverse reactions in breastfed infants reported in France over the dates January 1985 to June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, ketoprofen was one of the drugs most often suspected in serious adverse reactions, such as adverse renal and digestive system effects.[2]

Alternate Drugs to Consider

Acetaminophen, Flurbiprofen, Ibuprofen, Indomethacin, Naproxen, Piroxicam

References

1. Jacqz-Aigrain E, Serreau R, Boissinot C et al. Excretion of ketoprofen and nalbuphine in human milk during treatment of maternal pain after delivery. Ther Drug Monit. 2007;29:815-8. PMID: 18043481

2. Lacroix I, Soussan C, Portolan G, Montastruc JL. Drug-induced adverse reactions via breastfeeding: a study in the French Pharmacovigilance Database. Fundam Clin Pharmacol. 2013;27 (Suppl 1):42-3. Abstract 26-01. DOI: doi:10.1111/fcp.12025

Ketoprofen Identification

Substance Name

Ketoprofen

CAS Registry Number

22071-15-4

Drug Class

Analgesic Agents

Nonsteroidal Antiinflammatory Agents

Administrative Information

LactMed Record Number

624

Last Revision Date

20140708

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