Generic Name: alogliptin and metformin (AL oh GLIP tin and met FOR min)
Brand Names: Kazano
What is Kazano?
Kazano contains a combination of alogliptin and metformin. Alogliptin and metformin are oral diabetes medicines that help control blood sugar levels.
Metformin works by decreasing glucose (sugar) production in the liver and decreasing absorption of glucose by the intestines. Alogliptin works by regulating the levels of insulin your body produces after eating.
Kazano is used to treat type 2 diabetes. This medication is not for treating type 1 diabetes.
Kazano may also be used for purposes not listed in this medication guide.
You should not use Kazano if you have kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
Alogliptin can cause pancreatitis. Stop using Kazano and call your doctor at once if you have severe pain in your upper stomach spreading to your back, nausea and vomiting, and loss of appetite.
Some people develop lactic acidosis while taking metformin. Early symptoms may get worse over time and this condition can be fatal. Stop taking Kazano and get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, trouble breathing, stomach pain, nausea, and feeling very weak or tired.
Before taking this medicine
You should not use Kazano if you are allergic to alogliptin or metformin, or if you have:
kidney disease; or
if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
Some people taking Kazano develop a serious condition called lactic acidosis. This may be more likely if you have liver or kidney disease, congestive heart failure, a severe infection, if you are dehydrated, or if you drink large amounts of alcohol. Talk with your doctor about your risk.
To make sure Kazano is safe for you, tell your doctor if you have:
a history of pancreatitis;
a history of alcoholism; or
if you are over 80 years old and have not recently had your kidney function checked.
If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking Kazano. Be sure your caregivers know ahead of time that you are using this medicine.
Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs.
FDA pregnancy category B. Kazano is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
See also: Pregnancy and breastfeeding warnings (in more detail)
It is not known whether alogliptin and metformin passes into breast milk or if it could harm a nursing baby. Do not use Kazano without telling your doctor if you are breast-feeding a baby.
Do not give Kazano to anyone under 18 years old without medical advice.
How should I take Kazano?
Take Kazano exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Take Kazano with meals.
Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.
Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, pale skin, irritability, dizziness, feeling shaky, or trouble concentrating.
Keep a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency. If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it.
Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss.
Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your Kazano dose or dosage schedule without your doctor's advice.
Kazano is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.
Your doctor may have you take extra vitamin B12 while you are taking Kazano. Take only the amount of vitamin B12 that your doctor has prescribed.
Store Kazano at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember (be sure to take the medicine with food). Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. You may have signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).
What should I avoid?
Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis.
Kazano side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Kazano: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Some people develop lactic acidosis while taking Kazano. Early symptoms may get worse over time and this condition can be fatal. Stop taking this medicine and get emergency medical help if you have even mild symptoms such as:
muscle pain or weakness;
numb or cold feeling in your arms and legs;
feeling dizzy, light-headed, tired, or very weak;
stomach pain, nausea with vomiting; or
slow or uneven heart rate.
Stop using alogliptin and call your doctor at once if you have:
severe pain in your upper stomach spreading to your back;
nausea and vomiting, loss of appetite, fast heart rate;
pain or burning when you urinate;
itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
increased blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath);
severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common Kazano side effects may include:
back pain, headache; or
cold symptoms such as stuffy nose, sinus pain, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Kazano?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Kazano, especially:
acetazolamide, methazolamide, triamterene; or
heart or blood pressure medication--amiloride, digoxin, procainamide, quinidine.
You may be more likely to have hyperglycemia (high blood sugar) if you take Kazano with other drugs that can raise blood sugar, such as:
a diuretic or "water pill";
steroids (prednisone and others);
phenothiazines (Compazine and others);
thyroid medicine (Synthroid and others);
birth control pills and other hormones;
seizure medicines (Dilantin and others);
diet pills; and
medicines to treat asthma, colds or allergies.
These lists are not complete. Other drugs may interact with Kazano, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about Kazano (alogliptin / metformin)
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about Kazano.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Kazano only for the indication prescribed.
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
Copyright 1996-2015 Cerner Multum, Inc. Version: 1.02. Revision Date: 2013-04-26, 3:11:14 PM.