Kazano Side Effects

Generic Name: alogliptin / metformin

Note: This page contains side effects data for the generic drug alogliptin / metformin. It is possible that some of the dosage forms included below may not apply to the brand name Kazano.

It is possible that some side effects of Kazano may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to alogliptin / metformin: oral tablet

Along with its needed effects, alogliptin / metformin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking alogliptin / metformin:

More common
  • Blurred vision
  • dizziness
  • headache
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat
Less common
  • Anxiety
  • bladder pain
  • bloody or cloudy urine
  • chills
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • depression
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • increased hunger
  • lower back or side pain
  • nausea
  • nightmares
  • seizures
  • shakiness
  • slurred speech
  • unusual tiredness or weakness
  • Blistering, peeling, or loosening of the skin
  • bloating
  • constipation
  • cough
  • darkened urine
  • diarrhea
  • difficulty with swallowing
  • fever
  • hives
  • indigestion
  • itching
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • tightness in the chest
  • unusual tiredness or weakness
  • vomiting
  • yellow eyes or skin
Incidence not known
  • Dark-colored urine
  • general feeling of tiredness or weakness
  • light-colored stools
  • redness of the skin
  • stomach pain, continuing
  • welts

Some side effects of alogliptin / metformin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Body aches or pain
  • difficulty with breathing
  • ear congestion
  • loss of voice
  • muscle aches
  • sneezing
  • stuffy or runny nose
Less common
  • Back pain

For Healthcare Professionals

Applies to alogliptin / metformin: oral tablet


The most common adverse reactions reported include upper respiratory tract infection, nasopharyngitis, diarrhea, hypertension, headache, back pain, and urinary tract infection.


Common (1% to 10%): Hypertension (5.5%)

Common (1% to 10%): Hypertension (2.3%)

Common (1% to 10%): Hypertension (6%)


Common (1% to 10%): Hypoglycemia (up to 5.3%)

Common (1% to 10%): Hypoglycemia (up to 5.4%)

Common (1% to 10%): Hypoglycemia (up to 6.3%)


Common (1% to 10%): Diarrhea (5.5%)

Common (1% to 10%): Diarrhea (1.8%)
Uncommon (0.1% to 1%): Pancreatitis (0.2%)
Postmarketing reports: Acute pancreatitis

Very common (10% or more): Diarrhea (up to 53.2%), Nausea/vomiting (25.5%), flatulence (12.1%)
Common (1% to 10%): Indigestion (7.1%), abdominal discomfort (6.4%)


Common (1% to 10%): Urinary tract infection (4.2%)

Common (1% to 10%): Urinary tract infection (1.8%)

Common (1% to 10%): Urinary tract infection (3.7%)


Postmarketing reports: Hepatic enzyme elevations, fulminant hepatic failure


Uncommon (0.1% to 1%): Hypersensitivity reactions (0.6%)
Postmarketing reports: Anaphylaxis, angioedema, rash, urticaria, severe cutaneous adverse reactions (Stevens-Johnson syndrome)


Common (1% to 10%): Back pain (4.3%)

Uncommon (0.1% to 1%): Back pain (0.5%)

Common (1% to 10%): Asthenia (9.2%), back pain (4.5%)

Nervous system

Common (1% to 10%): Headache (5.3%)

Common (1% to 10%): Headache (up to 5%)

Common (1% to 10%): Headache (up to 5.7%)


Very common (10% or more): Upper respiratory tract infection (8%), nasopharyngitis (6.8%)

Common (1% to 10%): Nasopharyngitis (up to 4.4%), upper respiratory tract infection (up to 4.2%)

Common (1% to 10%): Upper respiratory tract infection (6.6%), nasopharyngitis (5.8%)

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