Kazano Side Effects

Generic Name: alogliptin / metformin

Note: This page contains information about the side effects of alogliptin / metformin. Some of the dosage forms included on this document may not apply to the brand name Kazano.

Not all side effects for Kazano may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to alogliptin / metformin: oral tablet

In addition to its needed effects, some unwanted effects may be caused by alogliptin / metformin. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking alogliptin / metformin:

More common
  • Blurred vision
  • dizziness
  • headache
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat
Less common
  • Anxiety
  • bladder pain
  • bloody or cloudy urine
  • chills
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • depression
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • increased hunger
  • lower back or side pain
  • nausea
  • nightmares
  • seizures
  • shakiness
  • slurred speech
  • unusual tiredness or weakness
Rare
  • Blistering, peeling, or loosening of the skin
  • bloating
  • constipation
  • cough
  • darkened urine
  • diarrhea
  • difficulty with swallowing
  • fever
  • hives
  • indigestion
  • itching
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • tightness in the chest
  • unusual tiredness or weakness
  • vomiting
  • yellow eyes or skin
Incidence not known
  • Dark-colored urine
  • general feeling of tiredness or weakness
  • light-colored stools
  • redness of the skin
  • stomach pain, continuing
  • welts

Some of the side effects that can occur with alogliptin / metformin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Body aches or pain
  • difficulty with breathing
  • ear congestion
  • loss of voice
  • muscle aches
  • sneezing
  • stuffy or runny nose
Less common
  • Back pain

For Healthcare Professionals

Applies to alogliptin / metformin: oral tablet

General

The most common adverse reactions reported include upper respiratory tract infection, nasopharyngitis, diarrhea, hypertension, headache, back pain, and urinary tract infection.

Cardiovascular

Alogliptin-Metformin:
Common (1% to 10%): Hypertension (5.5%)

Alogliptin:
Common (1% to 10%): Hypertension (2.3%)

Metformin:
Common (1% to 10%): Hypertension (6%)

Endocrine

Alogliptin-Metformin:
Common (1% to 10%): Hypoglycemia (up to 5.3%)

Alogliptin:
Common (1% to 10%): Hypoglycemia (up to 5.4%)

Metformin:
Common (1% to 10%): Hypoglycemia (up to 6.3%)

Gastrointestinal

Alogliptin-Metformin:
Common (1% to 10%): Diarrhea (5.5%)

Alogliptin:
Common (1% to 10%): Diarrhea (1.8%)
Uncommon (0.1% to 1%): Pancreatitis (0.2%)
Postmarketing reports: Acute pancreatitis

Metformin:
Very common (10% or more): Diarrhea (up to 53.2%), Nausea/vomiting (25.5%), flatulence (12.1%)
Common (1% to 10%): Indigestion (7.1%), abdominal discomfort (6.4%)

Genitourinary

Alogliptin-Metformin:
Common (1% to 10%): Urinary tract infection (4.2%)

Alogliptin:
Common (1% to 10%): Urinary tract infection (1.8%)

Metformin:
Common (1% to 10%): Urinary tract infection (3.7%)

Hepatic

Alogliptin:
Postmarketing reports: Hepatic enzyme elevations, fulminant hepatic failure

Hypersensitivity

Alogliptin:
Uncommon (0.1% to 1%): Hypersensitivity reactions (0.6%)
Postmarketing reports: Anaphylaxis, angioedema, rash, urticaria, severe cutaneous adverse reactions (Stevens-Johnson syndrome)

Musculoskeletal

Alogliptin-Metformin:
Common (1% to 10%): Back pain (4.3%)

Alogliptin:
Uncommon (0.1% to 1%): Back pain (0.5%)

Metformin:
Common (1% to 10%): Asthenia (9.2%), back pain (4.5%)

Nervous system

Alogliptin-Metformin:
Common (1% to 10%): Headache (5.3%)

Alogliptin:
Common (1% to 10%): Headache (up to 5%)

Metformin:
Common (1% to 10%): Headache (up to 5.7%)

Respiratory

Alogliptin-Metformin:
Very common (10% or more): Upper respiratory tract infection (8%), nasopharyngitis (6.8%)

Alogliptin:
Common (1% to 10%): Nasopharyngitis (up to 4.4%), upper respiratory tract infection (up to 4.2%)

Metformin:
Common (1% to 10%): Upper respiratory tract infection (6.6%), nasopharyngitis (5.8%)

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