Zolmitriptan Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Migraine

Zolmitriptan should only be used when a clear diagnosis of migraine has been established.

Oral:
Initial dose:
Recommended dose: 1.25 to 2.5 mg orally (placed on the tongue) once. May repeat in 2 hours if migraine is not resolved.
Maximum single dose: 5 mg
Maximum dose in a 24 hour period: 10 mg.

Intranasal:
Initial dose: 2.5 mg into one nostril once. May repeat in 2 hours if migraine is not resolved.
Adjusted dose: 2.5 to 5 mg (based on individual response) into one nostril once. May repeat in 2 hours if migraine is not resolved.
Maximum single dose: 5 mg
Maximum dose in a 24 hour period: 10 mg

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

The initial dose recommended for use in patients with hepatic dysfunction is 1.25 mg orally once.

Significant elevations in blood pressure have been reported in some patients with moderate to severe liver dysfunction. Therefore, both a lower dose and blood pressure monitoring are recommended for patients with liver dysfunction.

Dose Adjustments

The manufacturer reports that in the only direct comparison of 2.5 and 5 mg doses, there was little added benefit from the larger dose, but side effects were generally increased at 5 mg.

The safety of treating an average of more than 3 headaches in a 30 day period has not been established.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

The 2.5 mg tablets can be broken in half to give a 1.25 mg dose.

Some of the commercial preparations may contain phenylalanine.

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