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Vortioxetine Dosage

The information at is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Depression

Initial dose: 10 mg orally once a day
Maintenance dose: 20 mg orally once a day
Maximum dose: 20 mg orally once a day

Comments: 5 mg orally once a day may be considered for patients who do not tolerate higher doses

Approved indication: For the treatment of major depressive disorder (MDD)

Renal Dose Adjustments

Mild to end stage renal disease: No adjustment recommended

Liver Dose Adjustments

Mild to moderate hepatic impairment: No adjustment recommended
Severe hepatic impairment: Not recommended

Dose Adjustments

Patients who do not tolerate higher doses may be maintained on 5 mg orally once a day.

The maximum recommended dose in patients who are poor CYP450 2D6 metabolizers is 10 mg per day.

The vortioxetine dose should be reduced by one-half in patients taking a CYP450 2D6 strong inhibitor (e.g., bupropion, fluoxetine, paroxetine, or quinidine) concomitantly. When the CYP450 2D6 inhibitor is discontinued the vortioxetine dose may be increased to the original level.

The dose of vortioxetine should be increased when a strong CYP450 inducer (e.g., rifampin, carbamazepine, or phenytoin) is coadministered for greater than 14 days. This maximum dose should not exceed 3 times the original dose. When the inducer is discontinued, the dose of vortioxetine should be reduced to the original level within 14 days.


Consult WARNINGS section for dosing related precautions.


Data not available

Other Comments

Administration advice:
-Oral: Administer with or without food.
-At least 14 days should elapse between discontinuation of a MAOI and initiation of vortioxetine and at least 21 days should be allowed after stopping vortioxetine before starting an MAOI.