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Ramelteon Dosage

Applies to the following strength(s): 8 mg

The information at is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Insomnia

8 mg orally within 30 minutes of going to bed

Maximum Dose: 8 mg per day

Comments: This drug should not be taken with or immediately after a high-fat meal.

Use: Treatment of insomnia characterized by difficulty with sleep onset

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

-Mild Hepatic Impairment (Child-Pugh A): Data not available.
-Moderate Hepatic Impairment (Child-Pugh B): Use with caution.
-Severe Hepatic Impairment (Child-Pugh C): Not recommended.

Dose Adjustments

-Concomitant Use of CYP450 1A2 Inhibiting Drugs: Contraindicated with fluvoxamine; Caution recommended if used with other CYP450 1A2 inhibitors.

-Patients with Severe Sleep Apnea: Not recommended.


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


-Hemodialysis: No adjustment recommended.
-Peritoneal dialysis: Data not available.

Other Comments

Administration Advice:
-The drug tablet should be swallowed whole; tablets should not be broken.

Storage Requirements:
-The container should be kept tightly closed to protect from moisture and humidity.

-This drug does not appear to produce physical dependence; treatment discontinuation after chronic administration did not produce withdrawal signs in humans or in animals.
-If overdosage occurs, general symptomatic and supportive measures should be used along with immediate gastric lavage where appropriate and IV fluids as needed.

Patient Advice:
-Do not drink alcohol while taking this drug.
-Do not take other medications that can make you sleepy while taking this drug.
-Do not take this drug with food or right after a meal.
-Do not take this drug unless you are able to get a full night's sleep before you must be active again.
-After taking this drug, avoid driving and other activities that require concentration such as operating machinery; limit your activities to those necessary to prepare for bed.
-Consult your healthcare provider if your insomnia worsens or is not better within 7 to 10 days.