Lovastatin Dosage

This dosage information may not include all the information needed to use Lovastatin safely and effectively. See additional information for Lovastatin.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Hyperlipidemia

Immediate-release formulation:
Initial: 20 mg orally once a day with the evening meal.
Maintenance: 10 to 80 mg/day in 1 or 2 divided doses.
Lower doses are utilized for patients requiring a smaller reduction in cholesterol level.

Extended-release formulation:
Initial: 20, 40, or 60 mg orally once a day at bedtime. Patients requiring smaller reductions in cholesterol may start with 10 mg orally at bedtime.
Maintenance: 10 to 60 mg orally given once daily at bedtime.

Usual Pediatric Dose for Heterozygous Familial Hypercholesterolemia

10 to 17 years: 10 mg orally each day.
10 to 17 years: 10 to 40 mg orally each day. Dosage adjustments should be made no earlier than every 4 weeks, adding no more than 10 mg to the current dose each time.

Safety and efficacy in pediatrics have not been established, therefore, this formulation of lovastatin is not recommended for pediatric patients.

Renal Dose Adjustments

CrCl < 30 mL/min: Dosage increases above 20 mg orally once a day should be done with careful monitoring for adverse reactions.

Liver Dose Adjustments

Data not available

Dose Adjustments

Adjustments should be made at intervals of 4 weeks or more.

The concomitant use of lovastatin with CYP450 3A4 inhibitors should be avoided. Furthermore, lovastatin doses should not exceed 20 mg orally per day in patients receiving concomitant gemfibrozil, cyclosporine, danazol, niacin (doses greater than or equal 1 gram/day), or other fibrates. Lovastatin doses should not exceed 40 mg orally per day in patients receiving concomitant amiodarone or verapamil therapy.

In patients receiving a course of treatment with a systemic antifungal azole, macrolide antibiotic, or ketolide antibiotic, interruption of lovastatin therapy should be considered.


It is recommended that liver function tests be performed prior to initiation of therapy in patients with a history of liver disease, or when otherwise clinically indicated. It is also recommended that liver function tests be performed in all patients prior to use of 40 mg or more daily and thereafter when clinically indicated. Discontinuation of lovastatin therapy is recommended if liver function tests (AST or ALT) persist at three times the upper limit of normal or greater.


There are no data on the pharmacokinetics of lovastatin in patients on hemodialysis. Based on the pharmacokinetics of this drug, supplemental doses after dialysis do not appear to be necessary.

Other Comments

Cholesterol levels should be monitored periodically with consideration given to reducing the dosage if cholesterol levels fall significantly below the targeted range.

Extended-release tablets of lovastatin should be swallowed whole and not chewed or crushed.

Patients should immediately report any symptoms of muscle pain or weakness to a healthcare professional.

It has been suggested that prior to initiating statin therapy, all patients should have a baseline serum creatine kinase (CK) enzyme level measured and if at any time after initiating therapy a patient complains of muscle soreness, tenderness, or pain another CK level should be drawn for comparison. If elevated, the drug should be discontinued.

The results of one study indicate that withdrawal of HMG-CoA reductase inhibitors (statins; atorvastatin, fluvastatin, pravastatin, simvastatin) during the perioperative period in patients with acute coronary syndromes is associated with an increased risk for perioperative adverse cardiac events (i.e., increase postoperative troponin release and the combination of myocardial infarction and cardiovascular death). Patients receiving statins with extended-release formulations (i.e., fluvastatin) appeared to be associated with more favorable outcomes. Other studies appear to confirm these findings.