Lovastatin Pregnancy and Breastfeeding Warnings

Lovastatin is also known as: Altocor, Altoprev, Mevacor

Lovastatin Pregnancy Warnings

Lovastatin has been assigned to pregnancy category X by the FDA. Animal studies have revealed evidence of teratogenicity, including an increase in the incidence of skeletal malformations. There are no controlled data in human pregnancy. However, HMG-CoA reductase inhibitors are known to inhibit biosynthetic processes necessary in fetal development. The VATER association has been reported in one infant exposed to lovastatin and dextroamphetamine during organogenesis. Lovastatin use is considered contraindicated during pregnancy.

The VATER association (vertebral anomalies, anal atresia, tracheo-esophageal fistula with esophageal atresia, renal and radial dysplasia) was reported in an infant girl whose mother received lovastatin 10 mg daily and dextroamphetamine 10 mg daily during the first trimester of pregnancy for the treatment of hypercholesterolemia and progressive weight gain. Both drugs were discontinued five weeks later, at approximately nine weeks gestation, when pregnancy was confirmed.

Lovastatin Breastfeeding Warnings

There are no data on the excretion of lovastatin into human milk. The manufacturer considers lovastatin to be contraindicated during lactation.

See Also...

• Lovastatin use while Breastfeeding (in more detail)
• lovastatin Consumer Information
• Pregnancy Support Group
• FDA Pregnancy Categories
• Medicine use during Pregnancy
• Medicine use while Breastfeeding
• Safe Medications during Breastfeeding

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This drug information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.