Skip to Content

Disulfiram Dosage

Applies to the following strength(s): 250 mg ; 500 mg

The information at is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Alcohol Dependence

Initial: 500 mg orally once a day. This dose is generally continued for the first 1 to 2 weeks of abstinence of ethanol.

Maintenance: 250 mg orally once a day. Disulfiram is generally continued for at least 6 months to 1 year of abstinence from ethanol.

The maximum recommended dose is 500 mg/day.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

The 500 mg dose is usually continued for 1 to 2 weeks and then reduced to 250 mg per day.


Disulfiram should never be administered to a patient who is under the state of alcohol intoxication, or without the patient's full knowledge. Patients treated with disulfiram should be thoroughly educated, along with their relatives, about the reaction between disulfiram and alcohol.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).


Data not available

Other Comments

Disulfiram should never be given within 12 hours of ethanol ingestion. Likewise, ethanol should not be consumed for at least 14 days after the last disulfiram dose has been administered. Never administer disulfiram to an intoxicated individual. Fully advise a sober patient about to receive disulfiram of the consequences of drinking ethanol while on this medication. Advise patients to be alert and aware of the slight presence of ethanol in many nonprescription drugs, food and beverage preparations which may be present in quantities sufficient to cause a disulfiram-ethanol reaction.

Disulfiram is generally given for 6 months to 1 year.