Disulfiram Pregnancy and Breastfeeding Warnings

Disulfiram is also known as: Antabuse

Disulfiram Pregnancy Warnings

Disulfiram has been assigned to pregnancy category C by the FDA. There are no controlled data in human pregnancy. Although severe malformations have been reported with first-trimester disulfiram exposure, no consistent pattern of malformations has been seen. Disulfiram is only recommended for use during pregnancy when benefit outweighs risk.

A child born to a woman who received disulfiram for approximately the first two months of pregnancy, suffered from severe mental retardation, growth deficiency, and facial characteristics similar to that of fetal alcohol syndrome. However the mother denied alcohol use during the pregnancy. Severe limb-reduction has been reported in two infants born to mothers who had been maintained on disulfiram during the first trimester. One infant also had radial aplasia, vertebral fusion, and tracheo-esophageal fistula. Two cases of clubfoot have also been reported. Normal outcomes have also been reported in pregnancies which involved early disulfiram use.

Disulfiram Breastfeeding Warnings

There are no data on the excretion of disulfiram into human milk.

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