Medication Guide App

Codeine Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Geriatric Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Cough

Initial dose: 15 mg orally every 6 hours as necessary.
May titrate up to 20 mg every 4 hours.
Maximum 120 mg/day.

Usual Adult Dose for Pain

Initial dose: 30 mg orally, IM, subcutaneously, or IV every 6 hours as necessary. May titrate dose to achieve desired analgesic effect. Doses up to 60 mg orally, IM, subcutaneously, or IV every 4 hours have been used.

Usual Geriatric Dose for Cough

Initial dose: 10 mg orally every 6 hours as necessary.
May titrate cautiously up to 20 mg every 4 hours.
Maximum 120 mg/day.

Usual Geriatric Dose for Pain

Initial dose: 15 mg orally, IM, subcutaneously, or IV every 6 hours as necessary. May titrate dose to achieve desired analgesic effect. Doses up to 60 mg orally, IM, subcutaneously, or IV every 4 hours have been used.

Usual Pediatric Dose for Cough

2 to 6 years: 2.5 to 5 mg orally every 4 to 6 hours
Maximum 30 mg/day

6 to 12 years: 5 to 10 mg orally every 4 to 6 hours
Maximum 60 mg/day

Usual Pediatric Dose for Pain

1 year or greater: 0.5 mg/kg or 15 mg/m2 orally, IM, or subcutaneously every 4 to 6 hours as needed

Renal Dose Adjustments

Cough - CrCl less than 80 mL/min: Initial dose: 10 mg orally every 6 hours as necessary. May titrate cautiously up to 20 mg every 4 hours. Maximum 120 mg/day.

Pain - CrCl less than 80 mL/min: Initial dose: 15 mg orally, IM, subcutaneously, or IV every 6 hours as necessary. May titrate dose to achieve desired analgesic effect. Doses up to 60 mg orally, IM, subcutaneously, or IV every 4 hours have been used.

Liver Dose Adjustments

Initial dose: 10 mg orally every 6 hours as necessary.
May titrate cautiously up to 20 mg every 4 hours.
Maximum 120 mg/day.

Dose Adjustments

The dosage necessary for an antitussive effect is usually less than that for an analgesic effect.

Precautions

FDA is reviewing reports of children who developed serious adverse effects or died after taking codeine for pain relief after tonsillectomy and/or adenoidectomy for obstructive sleep apnea syndrome. Three pediatric deaths and one nonfatal but life-threatening case of respiratory depression were documented. These children (ages 2 to 5) had evidence of an inherited (genetic) ability to convert codeine into life-threatening or fatal amounts of morphine in the body (ultrarapid metabolizers). All children had received doses of codeine that were within the typical dose range. The lowest effective dose for the shortest period of time of any codeine containing drug should be used only on an as needed basis (i.e., not scheduled around the clock).

Caregivers who observe unusual sleepiness, confusion, or difficult or noisy breathing in their child should seek medical attention immediately, as these are signs of overdose.

Dialysis

Data not available

Other Comments

The IM and subcutaneous routes are generally preferred to the IV route if a parenteral route must be used. The IM and subcutaneous routes may carry a decreased risk of respiratory depression and hypotension compared to the IV route.

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