Medication Guide App

Articadent Dosage

Generic name: articaine hydrochloride and epinephrine bitartrate
Dosage form: injection

This dosage information does not include all the information needed to use Articadent safely and effectively. See full prescribing information for Articadent.

The information at is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Table 3 (Recommended Dosages) summarizes the recommended volumes and concentrations of Articadent™ for various types of anesthetic procedures. The dosages suggested in this table are for normal healthy adults, administered by submucosal infiltration and/or nerve block.

For most routine dental procedures 4% Articadent™ with epinephrine 1:200,000 is preferred. However, when more pronounced hemostasis is required, 4% Articadent™ with epinephrine 1:100,000 may be used.

Table 3. Recommended Dosages
Procedure Articadent™ Injection
Volume (mL) Total dose of articaine HCl (mg)
The above suggested volumes serve only as a guide. Other volumes may be used provided the total maximum recommended dose is not exceeded.
Infiltration 0.5 - 2.5 20 - 100
Nerve Block 0.5 - 3.4 20 - 136
Oral surgery 1.0 - 5.1 40 - 204

These recommended doses serve only as a guide to the amount of anesthetic required for most routine procedures. The actual volumes to be used depend on a number of factors such as type and extent of surgical procedure, depth of anesthesia, degree of muscular relaxation, and condition of the patient. In all cases, the smallest dose that will produce the desired result should be given. Dosages should be reduced for pediatric patients, elderly patients, and patients with cardiac and/or liver disease. See PRECAUTIONS; Pediatric Use and Geriatric Use.

The onset of anesthesia, and the duration of anesthesia are proportional to the volume and concentration (i.e., total dose) of local anesthetic used. Caution should be exercised when employing large volumes since the incidence of side effects may be dose-related.



For normal healthy adults, the maximum dose of articaine HCl administered by submucosal infiltration and/or nerve block should not exceed 7 mg/kg (0.175 mL/kg) or 3.2 mg/lb (0.0795 mL/lb) of body weight, e.g. 7 cartridges (11.9 mL) for a 150lb. patient.

Pediatric Patients

Use in pediatric patients under 4 years of age is not recommended. The quantity to be injected should be determined by the age and weight of the child and the magnitude of the operation. For children of less than 10 years who have a normal lean body mass and normal body development, the maximum dose may be determined by the application of one of the standard pediatric drug formulas. In any case, the maximum dose of 4% articaine HCl should not exceed the equivalent of 7 mg/kg (0.175 mL/kg) or 3.2 mg/lb (0.0795 mL/lb) of body weight.


For chemical disinfection of the carpule, either isopropyl alcohol (91%) or ethyl alcohol (70%) is recommended. Many commercially available brands of isopropyl (rubbing) alcohol, as well as solutions of ethyl alcohol not of U.S.P. grade, contain denaturants that are injurious to rubber and therefore are not to be used.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

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