Amlodipine / Olmesartan Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Initial dose: 1 tablet orally once a day.

The dosage of amlodipine-olmesartan should be based on the patient's requirements for each drug. The recommended dosage range for hypertension is 5 to 10 mg (amlodipine) and 20 to 40 mg (olmesartan) orally per day. Amlodipine-olmesartan may be used as initial therapy in patients who are likely to need multiple antihypertensive agents to achieve their blood pressure goals.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

The manufacturer recommends caution when administering this drug to patients with liver dysfunction.

Dose Adjustments

Use of a lower initial dose has been suggested for elderly patients because of decreased clearance of amlodipine in this patient population; however, a specific dose has not been recommended. No dosage adjustment based on olmesartan is required.

Precautions

Use of amlodipine-olmesartan during pregnancy is considered contraindicated. When pregnancy is detected or expected, amlodipine-olmesartan should be discontinued as soon as possible.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Limited data suggest that only a very small amount of amlodipine is removed by hemodialysis. The dialysis clearance of olmesartan is not known.

Other Comments

A patient whose blood pressure is inadequately controlled by either agent alone may be switched to the combination of amlodipine-olmesartan.

Amlodipine-olmesartan may be used for the initial therapy of hypertension.

Following initiation of therapy or a dose increase, efficacy should be reevaluated after 2 weeks of therapy.

Periodic monitoring of blood pressure has been suggested.

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