Cinacalcet

Pronunciation

Generic Name: cinacalcet (SIN-a-KAL-set)
Brand Name: Sensipar

Cinacalcet is used for:

Treating an overactive parathyroid gland in dialysis patients with chronic kidney disease. It is also used to treat high blood calcium levels in patients with parathyroid cancer. It is also used to treat severe high blood calcium levels in patients with an overactive parathyroid gland who are unable to undergo surgery to remove the parathyroid gland. It may also be used for other conditions as determined by your doctor.

Cinacalcet is a calcimimetic agent. It works by causing the parathyroid to produce less parathyroid hormone (PTH), which helps to lower blood calcium levels.

Do NOT use cinacalcet if:

  • you are allergic to any ingredient in cinacalcet
  • you have low blood calcium levels

Contact your doctor or health care provider right away if any of these apply to you.

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Before using cinacalcet:

Some medical conditions may interact with cinacalcet. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver problems
  • if you have a history of low blood pressure; fast, slow, or irregular heartbeat; heart problems (eg, heart failure); bone problems; low blood calcium levels; or seizures
  • if you are taking medicine to prevent seizures

Some MEDICINES MAY INTERACT with cinacalcet.

  • Azole antifungals (eg, itraconazole, ketoconazole) or erythromycin because they may increase the risk of cinacalcet's side effects
  • Carvedilol, flecainide, metoprolol, thioridazine, tricyclic antidepressants (eg, amitriptyline), or vinblastine because the risk of their side effects may be increased by cinacalcet

This may not be a complete list of all interactions that may occur. Ask your health care provider if cinacalcet may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use cinacalcet:

Use cinacalcet as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take cinacalcet by mouth with food or shortly after a meal.
  • Swallow cinacalcet whole. Do not break, crush, or chew before swallowing.
  • If you miss a dose of cinacalcet, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use cinacalcet.

Important safety information:

  • Cinacalcet may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use cinacalcet with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Lab tests, including calcium, phosphorous, and parathyroid hormone blood levels, may be performed while you take cinacalcet. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Cinacalcet should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking cinacalcet while you are pregnant. It is not known if cinacalcet is found in breast milk. Do not breast-feed while taking cinacalcet.

Possible side effects of cinacalcet:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; headache; loss of appetite; nausea; tiredness; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); burning, numbness, or tingling of the skin; chest pain; confusion; decreased urination; depression; fainting; fast, slow, or irregular heartbeat; joint pain; muscle aches, cramps, pain, spasms, or weakness; seizures; severe or persistent dizziness or headache; severe or persistent nausea or vomiting; shortness of breath; swelling of the hands or feet; tremors; unusual bone pain; unusual thirst; unusual tiredness or weakness; very dry mouth.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include burning, numbness, or tingling of the skin; muscle aches, cramps, pain, spasms, or weakness; seizures.

Proper storage of cinacalcet:

Store cinacalcet at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep cinacalcet out of the reach of children and away from pets.

General information:

  • If you have any questions about cinacalcet, please talk with your doctor, pharmacist, or other health care provider.
  • Cinacalcet is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take cinacalcet or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about cinacalcet. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to cinacalcet. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using cinacalcet.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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