Cinacalcet Side Effects

Not all side effects for cinacalcet may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to cinacalcet: oral tablet

In addition to its needed effects, some unwanted effects may be caused by cinacalcet. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking cinacalcet:

More common
  • Blurred vision
  • chest pain
  • dizziness
  • headache
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat
Less common
  • Convulsions
  • cough or hoarseness
  • fever or chills
  • loss of bladder control
  • lower back or side pain
  • muscle spasm or jerking of all extremities
  • painful or difficult urination
  • sudden loss of consciousness
Incidence not known
  • Abdominal or stomach cramps
  • confusion
  • decreased urine output
  • difficulty with breathing
  • difficulty with moving
  • dilated neck veins
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extreme fatigue
  • fainting
  • irregular breathing
  • irregular heartbeats
  • joint pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • low bone turnover
  • mood or mental changes
  • muscle aching or cramping
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle pains or stiffness
  • numbness and tingling around the mouth, fingertips, or feet
  • shortness of breath
  • sweating
  • swelling of the face, fingers, feet, or lower legs
  • swollen joints
  • tightness in the chest
  • tremor
  • troubled breathing
  • unusual tiredness or weakness
  • weight gain
  • wheezing

Some of the side effects that can occur with cinacalcet may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Diarrhea
  • lack or loss of strength
  • loss of appetite
  • nausea
  • vomiting
  • weight loss
Incidence not known
  • Hives or welts
  • itching
  • rash
  • redness of the skin

For Healthcare Professionals

Applies to cinacalcet: oral tablet

Cardiovascular

Common (1% to 10%): Hypertension (7%)
Postmarketing reports: Isolated, idiosyncratic cases of hypotension, worsening heart failure, and/or arrhythmia

Gastrointestinal

Very common (10% or more): Nausea (19 to 31%), vomiting (15 to 27%), diarrhea (20 to 21%)
Common (1% to 10%): Anorexia (6 to 7%), constipation (3 to 6%)

Musculoskeletal

Very common (10% or more): Myalgia (15%)
Common (1% to 10%): Fracture (6 to 8%), arthralgia (6%), noncardiac chest pain (6%), limb pain (5%)

Nervous system

Very common (10% or more):
Common (1% to 10%): Fatigue (8%), dizziness (7%), depression (6%), headache (6%), asthenia (6%)

Hypersensitivity

Postmarketing reports: Rash, angioedema, urticaria

Local

Common (1% to 10%): Access site infection (5%)

Dermatologic

Very common (10% or more): Paresthesia (14 to 29%)
Frequency not reported: One report of leukocytoclastic vasculitis with palpable purpura on both upper and lower extremities

Hematologic

Common (1% to 10%): Anemia (7%)

Metabolic

Common (1% to 10%): Dehydration (7%)

Respiratory

Very common (10% or more): Upper respiratory infection (11%)

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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