Cinacalcet Side Effects

Not all side effects for cinacalcet may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to cinacalcet: oral tablet

Along with its needed effects, cinacalcet may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cinacalcet:

More common
  • Blurred vision
  • chest pain
  • dizziness
  • headache
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat
Less common
  • Convulsions
  • cough or hoarseness
  • fever or chills
  • loss of bladder control
  • lower back or side pain
  • muscle spasm or jerking of all extremities
  • painful or difficult urination
  • sudden loss of consciousness
Incidence not known
  • Abdominal or stomach cramps
  • confusion
  • decreased urine output
  • difficulty with breathing
  • difficulty with moving
  • dilated neck veins
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extreme fatigue
  • fainting
  • irregular breathing
  • irregular heartbeats
  • joint pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • low bone turnover
  • mood or mental changes
  • muscle aching or cramping
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle pains or stiffness
  • numbness and tingling around the mouth, fingertips, or feet
  • shortness of breath
  • sweating
  • swelling of the face, fingers, feet, or lower legs
  • swollen joints
  • tightness in the chest
  • tremor
  • troubled breathing
  • unusual tiredness or weakness
  • weight gain
  • wheezing

Some side effects of cinacalcet may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Diarrhea
  • lack or loss of strength
  • loss of appetite
  • nausea
  • vomiting
  • weight loss
Incidence not known
  • Hives or welts
  • itching
  • rash
  • redness of the skin

For Healthcare Professionals

Applies to cinacalcet: oral tablet


Common (1% to 10%): Hypertension (7%)
Postmarketing reports: Isolated, idiosyncratic cases of hypotension, worsening heart failure, and/or arrhythmia


Very common (10% or more): Nausea (19 to 31%), vomiting (15 to 27%), diarrhea (20 to 21%)
Common (1% to 10%): Anorexia (6 to 7%), constipation (3 to 6%)


Very common (10% or more): Myalgia (15%)
Common (1% to 10%): Fracture (6 to 8%), arthralgia (6%), noncardiac chest pain (6%), limb pain (5%)

Nervous system

Very common (10% or more):
Common (1% to 10%): Fatigue (8%), dizziness (7%), depression (6%), headache (6%), asthenia (6%)


Postmarketing reports: Rash, angioedema, urticaria


Common (1% to 10%): Access site infection (5%)


Very common (10% or more): Paresthesia (14 to 29%)
Frequency not reported: One report of leukocytoclastic vasculitis with palpable purpura on both upper and lower extremities


Common (1% to 10%): Anemia (7%)


Common (1% to 10%): Dehydration (7%)


Very common (10% or more): Upper respiratory infection (11%)

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