Cinacalcet Side Effects

Not all side effects for cinacalcet may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to cinacalcet: oral tablet

In addition to its needed effects, some unwanted effects may be caused by cinacalcet. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking cinacalcet:

More common
  • Blurred vision
  • chest pain
  • dizziness
  • headache
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat
Less common
  • Convulsions
  • cough or hoarseness
  • fever or chills
  • loss of bladder control
  • lower back or side pain
  • muscle spasm or jerking of all extremities
  • painful or difficult urination
  • sudden loss of consciousness
Incidence not known
  • Abdominal or stomach cramps
  • confusion
  • decreased urine output
  • difficulty with breathing
  • difficulty with moving
  • dilated neck veins
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extreme fatigue
  • fainting
  • irregular breathing
  • irregular heartbeats
  • joint pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • low bone turnover
  • mood or mental changes
  • muscle aching or cramping
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle pains or stiffness
  • numbness and tingling around the mouth, fingertips, or feet
  • sweating
  • swelling of the face, fingers, feet, or lower legs
  • swollen joints
  • tightness in the chest
  • tremor
  • troubled breathing
  • unusual tiredness or weakness
  • weight gain

Some of the side effects that can occur with cinacalcet may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Diarrhea
  • lack or loss of strength
  • loss of appetite
  • nausea
  • vomiting
  • weight loss
Incidence not known
  • Hives or welts, itching, rash
  • redness of the skin

For Healthcare Professionals

Applies to cinacalcet: oral tablet


Common (1% to 10%): Hypertension (7%)
Postmarketing reports: Isolated, idiosyncratic cases of hypotension, worsening heart failure, and/or arrhythmia[Ref]


Very common (10% or more): Nausea (19 to 31%), vomiting (15 to 27%), diarrhea (20 to 21%)
Common (1% to 10%): Anorexia (6 to 7%), constipation (3 to 6%)[Ref]


Very common (10% or more): Myalgia (15%)
Common (1% to 10%): Fracture (6 to 8%), arthralgia (6%), noncardiac chest pain (6%), limb pain (5%)[Ref]

Nervous system

Very common (10% or more):
Common (1% to 10%): Fatigue (8%), dizziness (7%), depression (6%), headache (6%), asthenia (6%)[Ref]


Postmarketing reports: Rash, angioedema, urticaria


Common (1% to 10%): Access site infection (5%)


Very common (10% or more): Paresthesia (14 to 29%)
Frequency not reported: One report of leukocytoclastic vasculitis with palpable purpura on both upper and lower extremities[Ref]


Common (1% to 10%): Anemia (7%)


Common (1% to 10%): Dehydration (7%)


Very common (10% or more): Upper respiratory infection (11%)


1. "Product Information. Sensipar (cinacalcet)." Amgen USA, Thousand Oaks, CA.

2. Giannikopoulos G, Zorzou MP, Stamoulis I, et al. "Cinacalcet-induced leukocytoclastic vasculitis." Am J Kidney Dis 54 (2009): e5-e8

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