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Tamiflu Patient Tips

Medically reviewed on Nov 27, 2017 by C. Fookes, BPharm.

How it works

  • Tamiflu is a brand (trade) name for oseltamivir. Oseltamivir is an antiviral agent that may be used to treat acute and uncomplicated infections due to influenza A or B viruses in people who have been symptomatic for no more than 48 hours. The manufacturer suggests oseltamivir works by inhibiting viral neuraminidase, an enzyme that enables viruses to be released from their host cell. However, a Cochrane review suggests oseltamivir reduces symptoms of influenza by inhibiting the release of pro-inflammatory cytokines which reduces the immune response. It may also work centrally (through the brain) to lower temperature. The Cochrane reviewers did not find any evidence of influenza-virus specific action.
  • Tamiflu belongs to the class of medicines known as antivirals.

Upsides

  • Tamiflu can be used to treat influenza A or B in adults and children aged two weeks or older who have been symptomatic for no more than 48 hours.
  • Tamiflu may be used for to reduce the risk of adults and children aged one year or older from becoming infected with influenza A or B viruses.
  • May be more effective at preventing the symptoms of influenza rather than treating them.
  • Available as a capsule and a powder for oral suspension.
  • Tamiflu is available as a generic under the name oseltamivir.

Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

  • Nausea, vomiting, diarrhea, and headache are the main side effects. Rarely, allergic or skin reactions and breathing problems have been reported.
  • Tamiflu has been associated with neuropsychiatric side effects (mainly confusion, delirium and abnormal behavior that has resulted in injury; some cases were fatal). Most of these effects occurred in children and had an abrupt onset and a rapid resolution.
  • Tamiflu does not take the place of an early annual influenza vaccination.
  • There is always a risk that some influenza type A or B viruses may have developed resistance to Tamiflu and its antiviral effects. Doctors may need to consider local Tamiflu susceptibility patterns before deciding to use Tamiflu.
  • Rarely, anaphylaxis and serious skin reactions have been reported with Tamiflu.
  • Dosage may need adjusting in people with moderate-to-severe kidney disease. Avoid in people with end-stage kidney failure not undergoing dialysis. May not be suitable for some people with heart or lung disease, hereditary fructose intolerance, a weak immune system or other serious health problems.
  • Some studies have raised doubt about the effectiveness of Tamiflu as a treatment for influenza. A Cochrane review found that Tamiflu shortened the duration of symptoms of influenza-like illness by less than a day. Tamiflu is not effective against colds or other viral illnesses.
  • Tamiflu will not prevent any secondary bacterial infections associated with the flu.
  • Tamiflu may interact with some other medications including the live attenuated influenza vaccination and clopidogrel

Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. For a complete list of all side effects, click here.

Bottom Line

Tamiflu is an antiviral medicine that is used for the treatment or prevention of the flu. When used to treat the flu, it is most effective if started within 48 hours of symptom onset.

Tips

  • Tamiflu may be taken either with or without food. Taking with food may reduce any gastrointestinal side effects such as nausea or vomiting.
  • Tamiflu is usually taken twice daily when used for the treatment of influenza, or once daily when used to reduce the risk of catching influenza.
  • Tamiflu is usually taken for five days when used for treatment and 10 days when used for prevention. However, it may be continued for 6 to 12 weeks in certain situations.
  • Tamiflu should be started within 48 hours of symptom onset.
  • Tamiflu is available as capsules or an oral powder. The powder can be used by people who cannot swallow capsules and must be mixed with water immediately prior to use. Always use a properly calibrated measure when giving a dose of Tamiflu. One dose of Tamiflu powder delivers 2 grams of sorbitol which may cause dyspepsia and diarrhea in people with hereditary fructose intolerance.
  • If Tamiflu powder is not available, Tamiflu capsules may be opened and the contents mixed with sweetened liquids (regular or sugar-free) such as chocolate or corn syrup, caramel topping, or light brown sugar dissolved in water. A pharmacist is also able to prepare a suspension of Tamiflu.
  • Stop taking Tamiflu and see your doctor urgently if you develop any signs of an allergic reaction to Tamiflu (such as facial swelling or a skin rash), or if the person taking Tamiflu develops any worrying or bizarre behaviors, or appears confused or delirious.
  • Tamiflu only treats viruses, it will not treat bacterial infections. Do not use Tamiflu to treat any other infection, or give it to others to take.
  • If you have hereditary fructose intolerance, be aware that the oral suspension contains 2 grams of sorbitol which may give you dyspepsia or diarrhea.
  • You should not forgo your annual influenza vaccination just because Tamiflu is available. Continue to get a flu shot every year, based on your doctor's advice.

Response and Effectiveness

  • Tamiflu is rapidly absorbed from the gastrointestinal tract and its ingredient, oseltamivir, is converted by liver enzymes to its active form oseltamivir carboxylate (OC). OC is detected in the blood within 30 minutes of an oral dose. Peak concentrations of OC are reached within three to four hours.
  • Some studies have shown Tamiflu only reduce the duration of an influenza-like illness by about a day.

References

  • Tamiflu [Package Insert]. Revised 07/2017. Genentech, Inc. https://www.drugs.com/pro/tamiflu.html
  • Davies BE. Pharmacokinetics of oseltamivir: an oral antiviral for the treatment and prophylaxis of influenza in diverse populations. Journal of Antimicrobial Chemotherapy. 2010;65(Suppl 2):ii5-ii10. doi:10.1093/jac/dkq015
  • Jefferson T, Jones MA, Doshi P, et al. Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. Cochrane Database of Systematic Reviews 2014, Issue 4. Art. No.: CD008965. DOI: 10.1002/14651858.CD008965.pub4
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Tamiflu only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that this information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This drug information does not endorse drugs, diagnose patients or recommend therapy. It is an informational resource designed as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of this information. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2017 Drugs.com. Revision Date: 2017-11-27 20:19:53

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