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Zinc acetate Side Effects

For the Consumer

Applies to zinc acetate: capsules

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur while taking zinc acetate:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe vomiting; unusual restlessness; very dry mouth, eyes, or skin.

For Healthcare Professionals

Applies to zinc acetate: compounding powder, oral capsule


In general, zinc acetate is relatively nontoxic if used at recommended dosages.[Ref]


Although elevations in amylase, lipase and alkaline phosphatase have not been associated with any clinically significant events during clinical trials, it is suggested that liver and pancreatic function be closely monitored during zinc acetate therapy.

Hypocalcemia and decreased bone resorption have been demonstrated in animal models receiving high levels of dietary zinc.[Ref]

Hepatic side effects have included increases in amylase and lipase.[Ref]


Endocrine side effects have included the reduction of high density lipoprotein (HDL) in males.[Ref]

Due to an accompanying decrease in low density lipoproteins (LDL), the LDL/HDL ratio remains relatively unchanged and little risk is assumed in terms of coronary heart disease. Triglyceride levels have not been shown to be affected.[Ref]


In healthy subjects receiving zinc as a dietary supplement, lymphocyte stimulation, polymorphonuclear migration and phagocytosis were impaired. The clinical significance of this effect is unknown.[Ref]

Immunologic side effects have included a decrease in the immunologic response.[Ref]


Hematologic side effects have NOT included hematologic abnormalities due to iron deficiency anemia.[Ref]

Because zinc competes with the absorption of iron, copper and other minerals, it may be necessary to monitor the patient's iron status for any possible deficiencies.[Ref]


Gastrointestinal side effects have been reported the most frequently. These have included gastrointestinal upset, which may occur in up to 10% of patients.[Ref]

Gastrointestinal irritation appears to be dose-related.

To alleviated gastric upset and increase compliance, it has been suggested to administer the first morning dose between breakfast and lunch, rather than before breakfast.[Ref]


1. Yarze JC, Martin P, Munoz SJ, Friedman LS "Wilson's disease: current status." Am J Med 92 (1992): 643-54

2. Brewer GJ "Practical recommendations and new therapies for Wilson's disease." Drugs 50 (1995): 240-9

3. Brewer GJ, Yuzbasiyan-Gurkan V "Wilson disease." Medicine 71 (1992): 139-64

4. Walshe JM "Treatment of Wilson's disease with zinc sulphate." Br Med J (Clin Res Ed) 289 (1984): 558-9

5. Moore R "Bleeding gastric erosion after oral zinc sulphate." Br Med J 1 (1978): 754

6. Anderson LA. Hakojarvi SL, Boudreaux SK "Zinc acetate treatment in Wilson's disease." Ann Pharmacother 32 (1998): 78-87

7. "Product Information. Galzin (zinc acetate)." Gate Pharmaceuticals, Sellersville, PA.

It is possible that some side effects of zinc acetate may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.