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Visine Totality Multi-Symptom Relief Side Effects

Generic Name: tetrahydrozoline / zinc sulfate ophthalmic

Note: This page contains side effects data for the generic drug tetrahydrozoline / zinc sulfate ophthalmic. It is possible that some of the dosage forms included below may not apply to the brand name Visine Totality Multi-Symptom Relief.

For the Consumer

Applies to tetrahydrozoline / zinc sulfate ophthalmic: eye drops

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; minor stinging or tingling when the medicine is dropped into the eye.

Seek medical attention right away if any of these SEVERE side effects occur while taking tetrahydrozoline / zinc sulfate ophthalmic:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in vision; eye pain; worsening or persistent eye irritation or redness.

For Healthcare Professionals

Applies to tetrahydrozoline / zinc sulfate ophthalmic: ophthalmic solution


Ocular side effects have included temporary mydriasis, increased redness, and transient stinging after instillation. Other sympathomimetics have been associated with blurred vision, irritation, lacrimation, increased intraocular pressure, and punctate keratitis. Mydriasis, conjunctival hyperemia, and blepharoconjunctivitis have been reported with tetrahydrozoline.[Ref]

Nervous system

Nervous system side effects associated with ocular sympathomimetic agents have included headache, tremor, trembling, dizziness, nervousness, and drowsiness.[Ref]


Cardiovascular side effects associated with tetrahydrozoline have rarely included palpitations, hypertension, and bradycardia.[Ref]


1. "Product Information. Visine A.C. (tetrahydrozoline-zinc ophthalmic)." Pfizer U.S. Pharmaceuticals Group, New York, NY.

2. Soparkar CN, Wilhelmus KR, Koch DD, Wallace GW, Jones DB "Acute and chronic conjunctivitis due to over-the-counter ophthalmic decongestants." Arch Ophthalmol 115 (1997): 34-8

It is possible that some side effects of Visine Totality Multi-Symptom Relief may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

More about Visine Totality Multi-Symptom Relief (tetrahydrozoline / zinc sulfate ophthalmic)

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