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Visine Totality Multi-Symptom Relief Side Effects

Generic name: tetrahydrozoline / zinc sulfate ophthalmic

Note: This document contains side effect information about tetrahydrozoline / zinc sulfate ophthalmic. Some dosage forms listed on this page may not apply to the brand name Visine Totality Multi-Symptom Relief.

Applies to tetrahydrozoline/zinc sulfate ophthalmic: ophthalmic solution.


Tetrahydrozoline and zinc ophthalmic is for temporary relief of minor eye irritation, or to clear mucus build-up from the surface of the eye.

Stop using this medicine and call your doctor at once if you have ongoing or worsening eye redness, eye pain, or vision changes.

Get emergency medical help if you have any of these signs of an allergic reaction while taking tetrahydrozoline/zinc sulfate ophthalmic: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using tetrahydrozoline and zinc ophthalmic and call your doctor at once if you have:

  • ongoing or worsening eye redness;

  • eye pain;

  • changes in your vision;

  • chest pain, fast or uneven heart rate; or

  • severe headache, buzzing in your ears, anxiety, confusion, or feeling short of breath.

Common side effects may include:

  • mild burning or stinging of the eye;

  • blurred vision, watery eyes; or

  • dilated pupils.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to tetrahydrozoline / zinc sulfate ophthalmic: ophthalmic solution.


Frequency not reported: Changes in vision, enlarged pupils, eye irritation, eye pain, eye redness[Ref]


Frequency not reported: Temporary tingling sensation[Ref]

More about Visine Totality Multi-Symptom Relief (tetrahydrozoline / zinc sulfate ophthalmic)

Patient resources

Other brands

Visine A.C.

Related treatment guides


1. "Product Information. Visine A.C. (tetrahydrozoline-zinc ophthalmic)." Pfizer U.S. Pharmaceuticals Group (2003):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.