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Typhoid vaccine, inactivated Side Effects

For the Consumer

Applies to typhoid vaccine, inactivated: intramuscular injectable, intramuscular solution

Along with its needed effects, a vaccine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. It is very important that you tell your doctor about any side effects that occur after a dose of typhoid vaccine, even though the side effect may have gone away without treatment. Some types of side effects may mean that you should not receive any more doses of typhoid vaccine.

Check with your doctor immediately if any of the following side effects occur while taking typhoid vaccine, inactivated:

Rare
  • Difficulty in breathing or swallowing
  • hives
  • itching, especially of feet or hands
  • reddening of skin, especially around ears
  • swelling of eyes, face, or inside of nose
  • unusual tiredness or weakness (sudden and severe)

Some side effects of typhoid vaccine, inactivated may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Fever
  • general feeling of discomfort or illness
  • headache
  • muscle pain
  • pain, redness, or swelling at place of injection

For Healthcare Professionals

Applies to typhoid vaccine, inactivated: injectable suspension, intramuscular solution, oral delayed release capsule

General

The most common adverse events were injection site reactions.[Ref]

Local

Very common (10% or more): Tenderness (98%), pain (56%), induration (18%), soreness (13%), erythema (11%)
Common (1% to 10%): Swelling
Very rare (less than 0.01%): Edema[Ref]

Local reactions usually resolved within 48 hours of vaccination.[Ref]

Other

Very common (10% or more): Malaise (37%), fatigue (38%), feverish (subjective) (11.1%)
Common (1% to 10%): Fever of 100F or greater, decreased activity, elevated oral temperature, general aches
Postmarketing reports: Asthenia, flu-like episode[Ref]

Nervous system

Very common (10% or more): Headache (27%)
Postmarketing reports: Syncope without convulsions, loss of consciousness, tremor, vasovagal syncope in response to injection[Ref]

Hypersensitivity

Postmarketing reports: Anaphylaxis/anaphylactoid reactions including shock, serum sickness, allergic-type reactions such as pruritus, rash, urticaria, angioedema, difficulty breathing, or hypotension[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, diarrhea, vomiting
Postmarketing reports: Abdominal pain[Ref]

Dermatologic

Common (1% to 10%): Itching
Very rare (less than 0.01%): Urticaria, rash[Ref]

Musculoskeletal

Common (1% to 10%): Myalgia
Postmarketing reports: Arthralgia, cervical pain, polyarthritis[Ref]

Hematologic

Postmarketing reports: Lymphadenopathy, neutropenia[Ref]

Ocular

Postmarketing reports: Bilateral retinitis[Ref]

Renal

Postmarketing reports: Glomerulonephritis[Ref]

Respiratory

Postmarketing reports: Asthma[Ref]

References

1. "Product Information. Typhim Vi (typhoid vaccine)." Connaught, Swiftwater, PA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Some side effects of typhoid vaccine, inactivated may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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