Skip to main content

Typhoid vaccine, inactivated Side Effects

Medically reviewed by Last updated on Mar 26, 2024.

Applies to typhoid vaccine, inactivated: intramuscular solution.

Serious side effects

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

Other side effects

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to typhoid vaccine, inactivated: injectable suspension, intramuscular solution, oral delayed release capsule.


The most common adverse events were injection site reactions.[Ref]


Very common (10% or more): Tenderness (98%), pain (56%), induration (18%), soreness (13%), erythema (11%)

Common (1% to 10%): Swelling

Very rare (less than 0.01%): Edema[Ref]

Local reactions usually resolved within 48 hours of vaccination.[Ref]


Very common (10% or more): Malaise (37%), fatigue (38%), feverish (subjective) (11.1%)

Common (1% to 10%): Fever of 100F or greater, decreased activity, elevated oral temperature, general aches

Postmarketing reports: Asthenia, flu-like episode[Ref]

Nervous system

Very common (10% or more): Headache (27%)

Postmarketing reports: Syncope without convulsions, loss of consciousness, tremor, vasovagal syncope in response to injection[Ref]


Postmarketing reports: Anaphylaxis/anaphylactoid reactions including shock, serum sickness, allergic-type reactions such as pruritus, rash, urticaria, angioedema, difficulty breathing, or hypotension[Ref]


Common (1% to 10%): Nausea, diarrhea, vomiting

Postmarketing reports: Abdominal pain[Ref]


Common (1% to 10%): Itching

Very rare (less than 0.01%): Urticaria, rash[Ref]


Common (1% to 10%): Myalgia

Postmarketing reports: Arthralgia, cervical pain, polyarthritis[Ref]


Postmarketing reports: Lymphadenopathy, neutropenia[Ref]


Postmarketing reports: Bilateral retinitis[Ref]


Postmarketing reports: Glomerulonephritis[Ref]


Postmarketing reports: Asthma[Ref]


1. Product Information. Typhim VI (typhoid vaccine, inactivated). Apothecon Inc. 2022.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.