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Typhoid vaccine, inactivated Side Effects

Medically reviewed by Last updated on Oct 4, 2020.

For the Consumer

Applies to typhoid vaccine, inactivated: intramuscular solution

Side effects requiring immediate medical attention

Along with its needed effects, typhoid vaccine, inactivated may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking typhoid vaccine, inactivated:

More common

  • Fever
  • general feeling of discomfort or illness
  • pain, redness, swelling, tenderness or a lump at the place of injection
  • unusual tiredness or weakness

Incidence not known

  • Difficulty in breathing or swallowing
  • fainting
  • hives, itching, or redness of the skin
  • swelling of the eyes, face, or inside of the nose

Side effects not requiring immediate medical attention

Some side effects of typhoid vaccine, inactivated may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

  • Diarrhea
  • difficulty in moving
  • joint pain or swelling
  • muscle aches, cramps, pain, or stiffness
  • vomiting

For Healthcare Professionals

Applies to typhoid vaccine, inactivated: injectable suspension, intramuscular solution, oral delayed release capsule


The most common adverse events were injection site reactions.[Ref]


Very common (10% or more): Tenderness (98%), pain (56%), induration (18%), soreness (13%), erythema (11%)

Common (1% to 10%): Swelling

Very rare (less than 0.01%): Edema[Ref]

Local reactions usually resolved within 48 hours of vaccination.[Ref]


Very common (10% or more): Malaise (37%), fatigue (38%), feverish (subjective) (11.1%)

Common (1% to 10%): Fever of 100F or greater, decreased activity, elevated oral temperature, general aches

Postmarketing reports: Asthenia, flu-like episode[Ref]

Nervous system

Very common (10% or more): Headache (27%)

Postmarketing reports: Syncope without convulsions, loss of consciousness, tremor, vasovagal syncope in response to injection[Ref]


Postmarketing reports: Anaphylaxis/anaphylactoid reactions including shock, serum sickness, allergic-type reactions such as pruritus, rash, urticaria, angioedema, difficulty breathing, or hypotension[Ref]


Common (1% to 10%): Nausea, diarrhea, vomiting

Postmarketing reports: Abdominal pain[Ref]


Common (1% to 10%): Itching

Very rare (less than 0.01%): Urticaria, rash[Ref]


Common (1% to 10%): Myalgia

Postmarketing reports: Arthralgia, cervical pain, polyarthritis[Ref]


Postmarketing reports: Lymphadenopathy, neutropenia[Ref]


Postmarketing reports: Bilateral retinitis[Ref]


Postmarketing reports: Glomerulonephritis[Ref]


Postmarketing reports: Asthma[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Typhim Vi (typhoid vaccine)." Connaught, Swiftwater, PA.

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.