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Thrombinar Side Effects

Generic name: thrombin topical

Medically reviewed by Last updated on Oct 15, 2022.

Note: This document contains side effect information about thrombin topical. Some dosage forms listed on this page may not apply to the brand name Thrombinar.

Applies to thrombin topical: topical application powder for solution.

Serious side effects of Thrombinar

Along with its needed effects, thrombin topical (the active ingredient contained in Thrombinar) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking thrombin topical:

More common

  • Difficulty breathing
  • pain in the chest, groin, or legs, especially the calves
  • severe, sudden headache
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sudden, unexplained shortness of breath
  • vision changes

Other side effects of Thrombinar

Some side effects of thrombin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


  • Burning feeling, redness, swelling, itching, or skin rash at the place of application

For Healthcare Professionals

Applies to thrombin topical: nasal powder for reconstitution, topical kit, topical pad, topical powder for reconstitution, topical solution.


Hematologic side effects including increased activated partial thromboplastin time, increased international normalized ratio, decreased lymphocyte count, prolonged prothrombin time, and increased neutrophil count have been reported.[Ref]


Dermatologic side effects including pruritus have been reported.[Ref]


Gastrointestinal side effects including nausea and vomiting have been reported.


Local side effects including incision site complications have been reported.[Ref]


Immunologic side effects including antibody development have been reported.[Ref]


Hypersensitivity side effects including hypersensitivity reactions have been reported.[Ref]

More about Thrombinar (thrombin topical)

Patient resources

Other brands

Thrombin-JMI, Evithrom, Thrombi-Pad, Recothrom, ... +3 more

Professional resources

Related treatment guides


1. "Product Information. Recothrom (thrombin topical)." ZymoGenetics Inc (2008):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.