Sensorcaine-MPF With Epinephrine Side Effects

Generic name: bupivacaine / epinephrine

Medically reviewed by Drugs.com. Last updated on Mar 12, 2025.

Note: This document provides detailed information about Sensorcaine-MPF with Epinephrine.

Applies to bupivacaine / epinephrine: injection solution Side Effects associated with bupivacaine / epinephrine. Some dosage forms listed on this page may not apply specifically to the brand name Sensorcaine-MPF with Epinephrine.

Applies to bupivacaine / epinephrine: injection solution.

Precautions

It is very important that your doctor check your or your child's progress closely while receiving this medicine to see if it is working properly. Blood tests may be needed to check for any unwanted effects.

This medicine may cause a rare, but serious blood problem called methemoglobinemia. The risk may be increased in children younger than 6 months of age, elderly patients, or patients with certain inborn defects. It is more likely to occur in patients receiving too much of the medicine, but can also occur with small amounts. Check with your doctor right away if you or your child has the following symptoms after receiving this medicine: pale, gray, or blue-colored skin, lips, or nails, confusion, headache, lightheadedness, fast heartbeat, or unusual tiredness or weakness.

Tell your doctor or nurse right away if you have the following symptoms with this medicine: anxiety, blurred vision, depression, drowsiness, lightheadedness, nausea or vomiting, numbness and tingling of the mouth or lips, restlessness, ringing in the ears, speech problems, or tremors.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth, or throat after receiving this medicine.

This medicine may also increase your risk of having serious heart and blood vessel problems such as a heart attack, heart rhythm changes, or low blood pressure. Check with your doctor if you have chest pain or discomfort, pain or discomfort in the arms, jaw, back, or neck, dizziness, fainting, pounding, slow heartbeat, troubled breathing, or unusual tiredness or weakness.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects

Along with its needed effects, bupivacaine/epinephrine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking bupivacaine / epinephrine:

Other side effects

Some side effects of bupivacaine / epinephrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to bupivacaine / epinephrine: injectable solution.

General adverse events

Reactions to this drug are characteristic of those associated with other amide-type local anesthetics. A major cause of side effects can me associated with excessive plasma levels which may be due to overdose, unintentional intravascular injection, or slow metabolic degradation.^[Ref]

Cardiovascular

• Very common (10% or more): Hypotension
• Common (1% to 10%): Bradycardia, hypertension
• Rare (less than 0.1%): Cardiac arrest, cardiac arrhythmia
• Frequency not reported: Severe hypotension, cardiovascular collapse, tachycardia, maternal hypotension, ventricular fibrillation, ventricular tachycardia, ventricular arrhythmia, heart block, depression of myocardium^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea
• Common (1% to 10%): Vomiting
• Frequency not reported: Difficulty swallowing, fecal incontinence, loss of bowel control^[Ref]

Nervous system

• Common (1% to 10%): Paresthesia, dizziness
• Uncommon (0.1% to 1%): Central nervous system toxicity, convulsions, circumoral paresthesia, numbness of tongue, hyperacusis, loss of consciousness, tremor, light-headedness, dysarthria
• Rare (less than 0.1%): Neuropathy, peripheral nerve injury, arachnoiditis, paresis, paraplegia
• Frequency not reported: Unconsciousness, grand mal convulsion, drowsiness, convulsion, slurred speech, syncope, headache, persistent anesthesia, weakness, paralysis, loss of sphincter control, cranial nerve palsie^[Ref]

Genitourinary

• Common (1% to 10%): Urinary retention
• Frequency not reported: Urinary incontinence, loss of perineal sensation, loss of sexual function, loss of bladder control, labor slowed^[Ref]

Other

• Frequency not reported: Tinnitus, sensations of heat, sensations of cold, numbness, edema, death, septic meningitis, meningismus, forcep delivery increased^[Ref]

Dermatologic

• Frequency not reported: Cutaneous lesion, urticaria, excessive sweating, pruritus, erythema, angioedema, laryngeal edema^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Muscle twitch
• Frequency not reported: Backache^[Ref]

Metabolic

• Frequency not reported: Hyperkalemia, hypocalcemia, acidosis, hypocalcemia^[Ref]

Hepatic

• Frequency not reported: Hepatic dysfunction, ALT increased, AST increased^[Ref]

Ocular

• Uncommon (0.1% to 1%): Vision disturbed
• Rare (less than 0.1%): Diplopia
• Frequency not reported: Vision blurred, pupils constricted^[Ref]

Psychiatric

• Frequency not reported: Nervousness, apprehension, euphoria, confusion, agitation, excitation, depression, restlessness, anxiety^[Ref]

Respiratory

• Rare (less than 0.1%): Respiratory depression
• Frequency not reported: Apnea, hypoxia, hypercarbia, respiratory arrest, sneezing^[Ref]

Immunologic

• Rare (less than 0.1%): Allergic reaction, anaphylactic reaction/shock^[Ref]

See also:

Further information

Sensorcaine-MPF with Epinephrine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

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