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Poly-Tussin Side Effects

Generic Name: chlorcyclizine / codeine

Note: This document contains side effect information about chlorcyclizine / codeine. Some of the dosage forms listed on this page may not apply to the brand name Poly-Tussin.

Applies to chlorcyclizine / codeine: oral liquid

General

The most common side effects may include drowsiness, dizziness, and dry mouth.[Ref]

Respiratory

Frequency not reported: Respiratory depression

Gastrointestinal

Frequency not reported: Nausea, vomiting, constipation[Ref]

Psychiatric

Frequency not reported: Excitability

Nervous system

Frequency not reported: Drowsiness[Ref]

Cardiovascular

Frequency not reported: Hypotension, dizziness[Ref]

Dermatologic

Frequency not reported: Rashes, severe scarlatiniform eruptions, generalized dermatitis[Ref]

Genitourinary

Frequency not reported: Urinary retention[Ref]

Ocular

Frequency not reported: Blurred vision,

Antihistamines:
Frequency not reported: Worsening of closed-angle glaucoma (also called narrow-angle or angle-closure glaucoma)[Ref]

References

1. "Product Information. Codeine Sulfate (codeine)." Roxane Laboratories Inc, Columbus, OH.

2. American Geriatrics Society 2012 Beers Criteria Update Expert Panel "American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults." J Am Geriatr Soc 60 (2012): 616-31

3. Stringer MD, Greenfield S, McIrvine AJ "Stercoral perforation of the colon following postoperative analgesia." J R Soc Med 80 (1987): 115-6

4. Stambaugh JE Jr, McAdams J "Comparison of the analgesic efficacy and safety of oral ciramadol, codeine, and placebo in patients with chronic cancer pain." J Clin Pharmacol 27 (1987): 162-6

5. Max MB, Schafer SC, Culnane M, et al "Association of pain relief with drug side effects in postherpeticneuralgia: a single-dose study of clonidine, codeine, ibuprofen, and placebo." Clin Pharmacol Ther 43 (1988): 363-71

6. de Groot AC, Conemans J "Allergic urticarial rash from oral codeine." Contact Dermatitis 14 (1986): 209-14

7. "Product Information. Notuss-NX (chlorcyclizine-codeine)." SJ Pharmaceuticals formerly Stewart-Jackson Pharmacal Inc, Atlanta, GA.

8. Hastier P, Buckley MJM, Peten EP, Demuth N, Dumas R, Demarquay JF, CaroliBosc FX, Delmont JP "A new source of drug-induced acute pancreatitis: Codeine." Am J Gastroenterol 95 (2000): 3295-8

9. Shorr RI, Griffin MR, Daugherty JR, Ray WA "Opioid analgesics and the risk of hip fracture in the elderly: codeine and propoxyphene." J Gerontol 47 (1992): m111-5

10. Bradley CM, Nicholson AN "Effects of a mu-opoiod receptor agonist (codeine phosphate) on visuo-motor coordination and dynamic visual acuity in man." Br J Clin Pharmacol 22 (1986): 507-12

11. Malek-Ahmadi P, Ramsey ML "Acute psychosis associated with codeine and acetaminophen: a case report." Neurobehav Toxicol Teratol 7 (1985): 193-4

12. Cox RG "Hypoxaemia and hypotension after intravenous codeine phosphate." Can J Anaesth 41 (1994): 1211-3

13. Zolezzi M, Al Mohaimeed SA "Seizures with intravenous codeine phosphate." Ann Pharmacother 35 (2001): 1211-3

14. Redpath JB, Pleuvry BJ "Double-blind comparison of the respiratory and sedative effects of codeine phosphate and (+/-)-glaucine phosphate in human volunteers." Br J Clin Pharmacol 14 (1982): 555-8

15. Parke TJ, Nandi PR, Bird KJ, Jewkes DA "Profound hypotension following intravenous codeine phosphate: three case reports and some recommendations." Anaesthesia 47 (1992): 852-4

16. Gonzalogarijo MA, Revengaarranz F "Fixed drug eruption due to codeine." Br J Dermatol 135 (1996): 498-9

17. Hunskaar S, Dragsund S "Scarlatiniform rash and urticaria due to codeine." Ann Allergy 54 (1985): 240-1

18. Rodriguez F, Fernandez L, Garciaabujeta JL, Maquiera E, Llaca HF, Jerez J "Generalized dermatitis due to codeine." Contact Dermatitis 32 (1995): 120

19. Knaggs RD, Crighton IM, Cobby TF, Fletcher AJ, Hobbs GJ "The pupillary effects of intravenous morphine, codeine, and tramadol in volunteers." Anesth Analg 99 (2004): 108-12

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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