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Perimax Perio Rinse Side Effects

Generic name: hydrogen peroxide topical

Medically reviewed by Last updated on May 22, 2022.

Note: This document contains side effect information about hydrogen peroxide topical. Some of the dosage forms listed on this page may not apply to the brand name Perimax Perio Rinse.

Applies to hydrogen peroxide topical: topical application gel/jelly, topical application solution, topical application spray

Side effects requiring immediate medical attention

Along with its needed effects, hydrogen peroxide topical (the active ingredient contained in Perimax Perio Rinse) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking hydrogen peroxide topical:

More common

  • Redness, blistering, peeling, or loosening of the skin
  • skin burning, itching, pain, rash, stinging, or swelling skin ulcers

Less common

  • Cracking or scarring of the skin
  • thinning, weakness, or wasting away of the skin


  • Eyelid swelling
  • painful blisters on the trunk of the body

Side effects not requiring immediate medical attention

Some side effects of hydrogen peroxide topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Darkening of the skin
  • dryness, peeling, or crusting of the skin
  • lightening of normal skin color
  • lightening of the treated areas of dark skin

More about Perimax Perio Rinse (hydrogen peroxide topical)

Patient resources

Other brands

Eskata, Proxacol

Professional resources

Related treatment guides

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.