Skip to Content

Naropin Polyamp Side Effects

Generic Name: ropivacaine

Note: This document contains side effect information about ropivacaine. Some of the dosage forms listed on this page may not apply to the brand name Naropin Polyamp.

For the Consumer

Applies to ropivacaine: injection solution

Along with its needed effects, ropivacaine (the active ingredient contained in Naropin Polyamp) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ropivacaine:

Less common or rare
  • Burning or prickling sensation
  • fever
  • itching

Check with your doctor as soon as possible if any of the following side effects occur while taking ropivacaine:

Less common or rare

For Healthcare Professionals

Applies to ropivacaine: injectable solution


Reactions to this drug are characteristic of those associated with other amide-type local anesthetics. A major cause of side effects can me associated with excessive plasma levels which may be due to overdose, unintentional intravascular injection, or slow metabolic degradation.[Ref]


Very common (10% or more): Hypotension (up to 54.6%), bradycardia (up to 19.5%), fetal bradycardia (12.1%)
Common (1% to 10%): Hypertension, tachycardia, chest pain, fetal tachycardia, fetal distress
Uncommon (0.1% to 1%): Syncope, severe hypotension
Rare (less than 0.1%): Cardiac arrest, cardiac arrhythmia
Frequency not reported: Vasovagal reaction, postural hypotension, non-specific ECG abnormalities, extrasystole, nonspecific arrhythmia, atrial fibrillation, ST segment changes, myocardial infarction, deep vein thrombosis, phlebitis, pulmonary embolism[Ref]

Nervous system

Common (1% to 10%): Paresthesia, headache, dizziness, hypoesthesia
Uncommon (0.1% to 1%): CNS toxicity, convulsion, grand mal convulsions, seizure, lightheadedness, circumoral paresthesia, numbness of the tongue, hyperacusis, dysarthria, tremor
Frequency not reported: Horner's syndrome, paresis, dyskinesia, neuropathy, coma, convulsion, hypokinesia, hypotonia, ptosis, stupor, spinal cord dysfunction, anterior spinal artery syndrome, arachnoiditis, cauda equine, total spinal block, persistent anesthesia, weakness, paralysis of lower extremities, loss of sphincter control, septic meningitis[Ref]


Frequency not reported: Injection site pain[Ref]


Very common (10% or more): Nausea (up to 29.4%), vomiting (up to 14.6%)
Common (1% to 10%): Neonatal vomiting
Frequency not reported: Fecal incontinence, tenesmus[Ref]


Common (1% to 10%): Fever, pain, postoperative complication, rigors, neonatal complication, Apgar score low, neonatal fever, neonatal infection, temperature elevation, chills
Uncommon (0.1% to 1%): Tinnitus, hypothermia, neonatal sepsis
Frequency not reported: Malaise, asthenia, accident/injury, hearing abnormal, vertigo[Ref]


Common (1% to 10%): Urinary retention, oliguria, urinary tract infection, progression of labor poor/failed
Frequency not reported: Uterine atony, urinary incontinence, micturition disorder[Ref]


Common (1% to 10%): Pruritus
Rare (less than 0.1%): Angioedema, urticaria
Frequency not reported: Rash[Ref]


Common (1% to 10%): Anemia[Ref]


Common (1% to 10%): Neonatal jaundice
Frequency not reported: Jaundice[Ref]


Common (1% to 10%): Hypokalemia, neonatal hypoglycemia
Uncommon (0.1% to 1%): Fetal acidosis
Frequency not reported: Hypomagnesemia[Ref]


Very common (10% or more): Back pain (up to 16.4%)
Common (1% to 10%): Cramps
Uncommon (0.1% to 1%): Muscular twitch, muscular rigidity, hypotonia
Frequency not reported: Myalgia[Ref]


Frequency not reported: Vision abnormal, vision blurred, pupil constriction[Ref]


Common (1% to 10%): Anxiety, insomnia
Frequency not reported: Agitation, confusion, somnolence, nervousness, amnesia, hallucination, emotional lability, nightmares, restlessness, drowsiness, unconsciousness[Ref]


Common (1% to 10%): Dyspnea, rhinitis, neonatal respiratory disorder, neonatal tachypnea, hypoxia, hypercapnia, apnea
Frequency not reported: Bronchospasm, coughing, underventilation, apnea, respiratory paralysis[Ref]


Common (1% to 10%): Breast disorder/breastfeeding disorder[Ref]


Rare (less than 0.1%): Allergic reaction, anaphylactic reaction[Ref]


1. "Product Information. Naropin (ropivacaine)." Astra USA, Westborough, MA.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Some side effects of Naropin Polyamp may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.