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Naropin Novaplus Side Effects

Generic Name: ropivacaine

Note: This document contains side effect information about ropivacaine. Some of the dosage forms listed on this page may not apply to the brand name Naropin Novaplus.

For the Consumer

Applies to ropivacaine: injection solution

Along with its needed effects, ropivacaine (the active ingredient contained in Naropin Novaplus) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ropivacaine:

Less Common or Rare

  • Burning or prickling sensation
  • fever
  • itching

Check with your doctor as soon as possible if any of the following side effects occur while taking ropivacaine:

Less Common or Rare

For Healthcare Professionals

Applies to ropivacaine: injectable solution


Reactions to this drug are characteristic of those associated with other amide-type local anesthetics. A major cause of side effects can me associated with excessive plasma levels which may be due to overdose, unintentional intravascular injection, or slow metabolic degradation.[Ref]


Very common (10% or more): Hypotension (up to 54.6%), bradycardia (up to 19.5%), fetal bradycardia (12.1%)

Common (1% to 10%): Hypertension, tachycardia, chest pain, fetal tachycardia, fetal distress

Uncommon (0.1% to 1%): Syncope, severe hypotension

Rare (less than 0.1%): Cardiac arrest, cardiac arrhythmia

Frequency not reported: Vasovagal reaction, postural hypotension, non-specific ECG abnormalities, extrasystole, nonspecific arrhythmia, atrial fibrillation, ST segment changes, myocardial infarction, deep vein thrombosis, phlebitis, pulmonary embolism[Ref]

Nervous system

Common (1% to 10%): Paresthesia, headache, dizziness, hypoesthesia

Uncommon (0.1% to 1%): CNS toxicity, convulsion, grand mal convulsions, seizure, lightheadedness, circumoral paresthesia, numbness of the tongue, hyperacusis, dysarthria, tremor

Frequency not reported: Horner's syndrome, paresis, dyskinesia, neuropathy, coma, convulsion, hypokinesia, hypotonia, ptosis, stupor, spinal cord dysfunction, anterior spinal artery syndrome, arachnoiditis, cauda equine, total spinal block, persistent anesthesia, weakness, paralysis of lower extremities, loss of sphincter control, septic meningitis[Ref]


Frequency not reported: Injection site pain[Ref]


Very common (10% or more): Nausea (up to 29.4%), vomiting (up to 14.6%)

Common (1% to 10%): Neonatal vomiting

Frequency not reported: Fecal incontinence, tenesmus[Ref]


Common (1% to 10%): Fever, pain, postoperative complication, rigors, neonatal complication, Apgar score low, neonatal fever, neonatal infection, temperature elevation, chills

Uncommon (0.1% to 1%): Tinnitus, hypothermia, neonatal sepsis

Frequency not reported: Malaise, asthenia, accident/injury, hearing abnormal, vertigo[Ref]


Common (1% to 10%): Urinary retention, oliguria, urinary tract infection, progression of labor poor/failed

Frequency not reported: Uterine atony, urinary incontinence, micturition disorder[Ref]


Common (1% to 10%): Pruritus

Rare (less than 0.1%): Angioedema, urticaria

Frequency not reported: Rash[Ref]


Common (1% to 10%): Anemia[Ref]


Common (1% to 10%): Neonatal jaundice

Frequency not reported: Jaundice[Ref]


Common (1% to 10%): Hypokalemia, neonatal hypoglycemia

Uncommon (0.1% to 1%): Fetal acidosis

Frequency not reported: Hypomagnesemia[Ref]


Very common (10% or more): Back pain (up to 16.4%)

Common (1% to 10%): Cramps

Uncommon (0.1% to 1%): Muscular twitch, muscular rigidity, hypotonia

Frequency not reported: Myalgia[Ref]


Frequency not reported: Vision abnormal, vision blurred, pupil constriction[Ref]


Common (1% to 10%): Anxiety, insomnia

Frequency not reported: Agitation, confusion, somnolence, nervousness, amnesia, hallucination, emotional lability, nightmares, restlessness, drowsiness, unconsciousness[Ref]


Common (1% to 10%): Dyspnea, rhinitis, neonatal respiratory disorder, neonatal tachypnea, hypoxia, hypercapnia, apnea

Frequency not reported: Bronchospasm, coughing, underventilation, apnea, respiratory paralysis[Ref]


Common (1% to 10%): Breast disorder/breastfeeding disorder[Ref]


Rare (less than 0.1%): Allergic reaction, anaphylactic reaction[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Naropin (ropivacaine)." Astra USA, Westborough, MA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.