Mintezol Side Effects

Generic name: thiabendazole

Note: This document provides detailed information about Mintezol.

Applies to thiabendazole: oral suspension, oral tablet chewable Side Effects associated with thiabendazole. Some dosage forms listed on this page may not apply specifically to the brand name Mintezol.

Applies to thiabendazole: oral suspension, oral tablet chewable.

Precautions

It is important that your doctor check your progress at regular visits. This is to make sure that the infection is cleared up completely.

Thiabendazole may cause blurred vision or yellow vision. It may also cause some people to become dizzy, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert or able to see well. If these reactions are especially bothersome, check with your doctor.

Good health habits are required to help prevent reinfection. These include the following:

• For creeping eruption (cutaneous larva migrans) or visceral larva migrans (toxocariasis):
  • Keep dogs and cats off beaches and bathing areas.
  • Treat household pets for worms (deworm) regularly.
  • Cover children's sandboxes when not being used.
  • These measures help to prevent contamination of the sand or soil by worm larvae from the animals' wastes. This helps to keep children from picking up the larvae when they put their hands in their mouths after touching contaminated sand or soil.
• For pork worms (trichinosis):
  • Cook all pork, pork-containing products, and game at not less than 140 °F (60 °C) until well done (not pink in the center) before eating. This will kill any trichinosis larvae that may be in the meat.

Serious side effects of Mintezol

Along with its needed effects, thiabendazole (the active ingredient contained in Mintezol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking thiabendazole:

Check with your doctor as soon as possible if any of the following side effects occur while taking thiabendazole:

Other side effects of Mintezol

Some side effects of thiabendazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

This medicine may cause the urine to have an asparagus-like or other unusual odor while you are taking it and for about 24 hours after you stop taking it. This side effect does not need medical attention.

For healthcare professionals

Applies to thiabendazole: compounding powder, oral suspension, oral tablet chewable.

Gastrointestinal adverse events

Gastrointestinal side effects have commonly included nausea, vomiting, anorexia, and abdominal pain. These side effects generally only last 1 to 2 days and do not require drug discontinuation. Epigastric distress and abdominal pain have also been reported.^[Ref]

Nervous system

Nervous system side effects have included drowsiness, dizziness, giddiness, headache, paresthesias, weariness, numbness, hyperirritability, convulsions, collapse, confusion, depression, floating sensation, weakness, and lack of coordination.^[Ref]

Hypersensitivity

Hypersensitivity adverse effects have included pruritic rash reactions, fever, facial flush, chills, conjunctival injection, angioedema, anaphylaxis, skin rashes (including perianal), erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis, and lymphadenopathy.^[Ref]

Erythema multiforme (including Stevens-Johnson syndrome) and toxic epidermal necrolysis generally do not occur for several weeks after thiabendazole is discontinued. The reaction generally starts with a skin eruption which quickly progresses. Two reported cases had complete recovery after several weeks of therapy.^[Ref]

Hepatic

Hepatic side effects reported have included liver damage. It may manifest as jaundice, cholestasis, sicca syndrome, malaise, light-colored stools, and gastrointestinal upset. These symptoms generally do not occur for several weeks following thiabendazole (the active ingredient contained in Mintezol) therapy completion. Therapy usually consists of only supportive measures. In most cases the hepatic damage is reversible, although at least one patient has died as a result of hepatic damage. Sicca complex has also been reported.^[Ref]

Sicca complex has been frequently noted with the hepatic changes associated with thiabendazole. This clinical picture includes keratoconjunctivitis sicca and xerostomia. This also appears to be reversible in most cases without medical intervention.^[Ref]

Ocular

Ocular side effects have included abnormal sensation in eyes, xanthopsia, blurred vision, and transient disturbances in vision.

Cardiovascular

Cardiovascular side effects have included hypotension.

Metabolic

Metabolic side effects have included hyperglycemia.

Hematologic

Hematologic side effects have included transient leukopenia.

Genitourinary

Genitourinary side effects have included hematuria, enuresis, malodor of the urine, and crystalluria.

Psychiatric

Psychiatric side effects have included psychic alterations.

Other

Other side effects have included tinnitus, drying of mucous membranes, and live Ascaris in the mouth and nose.

See also:

Further information

Mintezol side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer